Compound anisodine combined with retinal laser photocoagulation for the treatment of severe non-proliferative diabetic retinopathy
AIM: To investigate the clinical efficacy of the compound anisodine combined with retinal laser photocoagulation in the treatment of severe non-proliferative diabetic retinopathy(NPDR). METHODS: According to the retrospective study, totally 120 eyes of patients with severe NPDR who admitted to Daxin...
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Press of International Journal of Ophthalmology (IJO PRESS)
2024-05-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2024/5/202405024.pdf |
| _version_ | 1797194656134463488 |
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| author | An Xin Jiao Jian Wei Wenbin Zhang Moli |
| author_facet | An Xin Jiao Jian Wei Wenbin Zhang Moli |
| author_sort | An Xin |
| collection | DOAJ |
| description | AIM: To investigate the clinical efficacy of the compound anisodine combined with retinal laser photocoagulation in the treatment of severe non-proliferative diabetic retinopathy(NPDR). METHODS: According to the retrospective study, totally 120 eyes of patients with severe NPDR who admitted to Daxing Teaching Hospital Affiliated to Capital Medical University from May 2023 to July 2023 were selected. The patients were divided into the observation group and the control group according to treatment methods, with 60 eyes in each group. The observation group was treated with panretinal photocoagulation combined with the compound anisodine injection. The control group was only treated with panretinal photocoagulation. The optical coherence tomography angiography(OCTA)and optical coherence tomography(OCT)were used to quantitatively analyze the fundus retinal structure and blood flow. Furthermore, the best corrected visual acuity(BCVA), superficial vascular density(SVD), deep vascular density(DVD), choroidal blood flow density and central macular foveal retinal thickness(CMT)were compared before treatment and at 1 d, 1 and 2 mo after treatment.RESULTS:At 2 mo postoperatively, the rate of visual improvement and the BCVA in the observation group of patients were significantly better than those of the control group, and the incidence of macular edema in the observation group was significantly lower than the control group(P<0.05). The BCVA at 1 and 2 mo after treatment were significantly higher than those before treatment in both groups(P<0.05). The SVD in the observation group was better than the control group at 1 d, 1 and 2 mo after treatment(all P<0.05). The DVD and choroidal flow density in the observation group were better than those of the control group at 1 d after treatment(all P<0.05). The CMT of the observation group was smaller than that of the control group at 1 d after treatment(P<0.05).CONCLUSION:Compound anisodine can effectively improve the fundus microcirculation after panretinal photocoagulation and reduce the incidence of macular edema, thus promoting the visual function. |
| first_indexed | 2024-04-24T05:59:45Z |
| format | Article |
| id | doaj.art-49fdc4811a5c4cc0a30a5ac69e658d54 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 |
| language | English |
| last_indexed | 2024-04-24T05:59:45Z |
| publishDate | 2024-05-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-49fdc4811a5c4cc0a30a5ac69e658d542024-04-23T08:29:23ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51232024-05-0124579079410.3980/j.issn.1672-5123.2024.5.24202405024Compound anisodine combined with retinal laser photocoagulation for the treatment of severe non-proliferative diabetic retinopathyAn Xin0Jiao Jian1Wei Wenbin2Zhang Moli3Department of Ophthalmology, Daxing Teaching Hospital Affiliated to Capital Medical University, Beijing 102600, ChinaDepartment of Ophthalmology, Daxing Teaching Hospital Affiliated to Capital Medical University, Beijing 102600, ChinaBeijing Tongren Hospital, Capital Medical University;Beijing Tongren Eye Center;Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment;Beijing Key Laboratory of Ophthalmology & Visual Sciences;Medical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information Technology, Beijing 100730, ChinaDepartment of Ophthalmology, Daxing Teaching Hospital Affiliated to Capital Medical University, Beijing 102600, ChinaAIM: To investigate the clinical efficacy of the compound anisodine combined with retinal laser photocoagulation in the treatment of severe non-proliferative diabetic retinopathy(NPDR). METHODS: According to the retrospective study, totally 120 eyes of patients with severe NPDR who admitted to Daxing Teaching Hospital Affiliated to Capital Medical University from May 2023 to July 2023 were selected. The patients were divided into the observation group and the control group according to treatment methods, with 60 eyes in each group. The observation group was treated with panretinal photocoagulation combined with the compound anisodine injection. The control group was only treated with panretinal photocoagulation. The optical coherence tomography angiography(OCTA)and optical coherence tomography(OCT)were used to quantitatively analyze the fundus retinal structure and blood flow. Furthermore, the best corrected visual acuity(BCVA), superficial vascular density(SVD), deep vascular density(DVD), choroidal blood flow density and central macular foveal retinal thickness(CMT)were compared before treatment and at 1 d, 1 and 2 mo after treatment.RESULTS:At 2 mo postoperatively, the rate of visual improvement and the BCVA in the observation group of patients were significantly better than those of the control group, and the incidence of macular edema in the observation group was significantly lower than the control group(P<0.05). The BCVA at 1 and 2 mo after treatment were significantly higher than those before treatment in both groups(P<0.05). The SVD in the observation group was better than the control group at 1 d, 1 and 2 mo after treatment(all P<0.05). The DVD and choroidal flow density in the observation group were better than those of the control group at 1 d after treatment(all P<0.05). The CMT of the observation group was smaller than that of the control group at 1 d after treatment(P<0.05).CONCLUSION:Compound anisodine can effectively improve the fundus microcirculation after panretinal photocoagulation and reduce the incidence of macular edema, thus promoting the visual function.http://ies.ijo.cn/cn_publish/2024/5/202405024.pdfcompound anisodinesevere non-proliferative diabetic retinopathyoptical coherence tomography angiographymacular edemapanretinal photocoagulation |
| spellingShingle | An Xin Jiao Jian Wei Wenbin Zhang Moli Compound anisodine combined with retinal laser photocoagulation for the treatment of severe non-proliferative diabetic retinopathy Guoji Yanke Zazhi compound anisodine severe non-proliferative diabetic retinopathy optical coherence tomography angiography macular edema panretinal photocoagulation |
| title | Compound anisodine combined with retinal laser photocoagulation for the treatment of severe non-proliferative diabetic retinopathy |
| title_full | Compound anisodine combined with retinal laser photocoagulation for the treatment of severe non-proliferative diabetic retinopathy |
| title_fullStr | Compound anisodine combined with retinal laser photocoagulation for the treatment of severe non-proliferative diabetic retinopathy |
| title_full_unstemmed | Compound anisodine combined with retinal laser photocoagulation for the treatment of severe non-proliferative diabetic retinopathy |
| title_short | Compound anisodine combined with retinal laser photocoagulation for the treatment of severe non-proliferative diabetic retinopathy |
| title_sort | compound anisodine combined with retinal laser photocoagulation for the treatment of severe non proliferative diabetic retinopathy |
| topic | compound anisodine severe non-proliferative diabetic retinopathy optical coherence tomography angiography macular edema panretinal photocoagulation |
| url | http://ies.ijo.cn/cn_publish/2024/5/202405024.pdf |
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