Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy
Pregnancy makes women more susceptible to infectious agents; however, available data on the effect of SARS-CoV-2 on pregnant women are limited. To date, inflammatory responses and changes in serum metal concentration have been reported in COVID-19 patients, but few associations between metal ions an...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.935363/full |
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| author | Johana Vásquez-Procopio Johana Vásquez-Procopio Aurora Espejel-Nuñez Johnatan Torres-Torres Raigam Jafet Martinez-Portilla Salvador Espino Y. Sosa Paloma Mateu-Rogell Veronica Ortega-Castillo Maricruz Tolentino-Dolores Otilia Perichart-Perera José Osman Franco-Gallardo José Alberto Carranco-Martínez Scarleth Prieto-Rodríguez Mario Guzmán-Huerta Fanis Missirlis Guadalupe Estrada-Gutierrez |
| author_facet | Johana Vásquez-Procopio Johana Vásquez-Procopio Aurora Espejel-Nuñez Johnatan Torres-Torres Raigam Jafet Martinez-Portilla Salvador Espino Y. Sosa Paloma Mateu-Rogell Veronica Ortega-Castillo Maricruz Tolentino-Dolores Otilia Perichart-Perera José Osman Franco-Gallardo José Alberto Carranco-Martínez Scarleth Prieto-Rodríguez Mario Guzmán-Huerta Fanis Missirlis Guadalupe Estrada-Gutierrez |
| author_sort | Johana Vásquez-Procopio |
| collection | DOAJ |
| description | Pregnancy makes women more susceptible to infectious agents; however, available data on the effect of SARS-CoV-2 on pregnant women are limited. To date, inflammatory responses and changes in serum metal concentration have been reported in COVID-19 patients, but few associations between metal ions and cytokines have been described. The aim of this study was to evaluate correlations between inflammatory markers and serum metal ions in third-trimester pregnant women with varying COVID-19 disease severity. Patients with severe symptoms had increased concentrations of serum magnesium, copper, and calcium ions and decreased concentrations of iron, zinc, and sodium ions. Potassium ions were unaffected. Pro-inflammatory cytokines IL-6, TNF-α, IL-8, IL-1α, anti-inflammatory cytokine IL-4, and the IP-10 chemokine were induced in the severe presentation of COVID-19 during pregnancy. Robust negative correlations between iron/magnesium and zinc/IL-6, and a positive correlation between copper/IP-10 were observed in pregnant women with the severe form of the disease. Thus, coordinated alterations of serum metal ions and inflammatory markers – suggestive of underlying pathophysiological interactions—occur during SARS-CoV-2 infection in pregnancy. |
| first_indexed | 2024-12-10T21:36:49Z |
| format | Article |
| id | doaj.art-4a010235819a49d5931ca34b9bfba305 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-10T21:36:49Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-4a010235819a49d5931ca34b9bfba3052022-12-22T01:32:37ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-08-011010.3389/fcell.2022.935363935363Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During PregnancyJohana Vásquez-Procopio0Johana Vásquez-Procopio1Aurora Espejel-Nuñez2Johnatan Torres-Torres3Raigam Jafet Martinez-Portilla4Salvador Espino Y. Sosa5Paloma Mateu-Rogell6Veronica Ortega-Castillo7Maricruz Tolentino-Dolores8Otilia Perichart-Perera9José Osman Franco-Gallardo10José Alberto Carranco-Martínez11Scarleth Prieto-Rodríguez12Mario Guzmán-Huerta13Fanis Missirlis14Guadalupe Estrada-Gutierrez15Department of Immunobiochemistry, Instituto Nacional de Perinatología, Mexico City, MexicoDepartment of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies (Cinvestav), Mexico City, MexicoDepartment of Immunobiochemistry, Instituto Nacional de Perinatología, Mexico City, MexicoClinical Research Division, Instituto Nacional de Perinatología, Mexico City, MexicoClinical Research Division, Instituto Nacional de Perinatología, Mexico City, MexicoClinical Research Division, Instituto Nacional de Perinatología, Mexico City, MexicoClinical Research Division, Instituto Nacional de Perinatología, Mexico City, MexicoDepartment of Obstetrics, Instituto Nacional de Perinatología, Mexico City, MexicoDepartment of Nutrition and Bioprogramming, Instituto Nacional de Perinatología, Mexico City, MexicoDepartment of Nutrition and Bioprogramming, Instituto Nacional de Perinatología, Mexico City, MexicoData Science Department, Openlab, Mexico City, MexicoDepartment of Translational Medicine, Instituto Nacional de Perinatología, Mexico City, MexicoDepartment of Translational Medicine, Instituto Nacional de Perinatología, Mexico City, MexicoDepartment of Translational Medicine, Instituto Nacional de Perinatología, Mexico City, MexicoDepartment of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies (Cinvestav), Mexico City, MexicoResearch Division, Instituto Nacional de Perinatología, Mexico City, MexicoPregnancy makes women more susceptible to infectious agents; however, available data on the effect of SARS-CoV-2 on pregnant women are limited. To date, inflammatory responses and changes in serum metal concentration have been reported in COVID-19 patients, but few associations between metal ions and cytokines have been described. The aim of this study was to evaluate correlations between inflammatory markers and serum metal ions in third-trimester pregnant women with varying COVID-19 disease severity. Patients with severe symptoms had increased concentrations of serum magnesium, copper, and calcium ions and decreased concentrations of iron, zinc, and sodium ions. Potassium ions were unaffected. Pro-inflammatory cytokines IL-6, TNF-α, IL-8, IL-1α, anti-inflammatory cytokine IL-4, and the IP-10 chemokine were induced in the severe presentation of COVID-19 during pregnancy. Robust negative correlations between iron/magnesium and zinc/IL-6, and a positive correlation between copper/IP-10 were observed in pregnant women with the severe form of the disease. Thus, coordinated alterations of serum metal ions and inflammatory markers – suggestive of underlying pathophysiological interactions—occur during SARS-CoV-2 infection in pregnancy.https://www.frontiersin.org/articles/10.3389/fcell.2022.935363/fullSARS – CoV – 2placentazinccopperIL-6 |
| spellingShingle | Johana Vásquez-Procopio Johana Vásquez-Procopio Aurora Espejel-Nuñez Johnatan Torres-Torres Raigam Jafet Martinez-Portilla Salvador Espino Y. Sosa Paloma Mateu-Rogell Veronica Ortega-Castillo Maricruz Tolentino-Dolores Otilia Perichart-Perera José Osman Franco-Gallardo José Alberto Carranco-Martínez Scarleth Prieto-Rodríguez Mario Guzmán-Huerta Fanis Missirlis Guadalupe Estrada-Gutierrez Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy Frontiers in Cell and Developmental Biology SARS – CoV – 2 placenta zinc copper IL-6 |
| title | Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy |
| title_full | Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy |
| title_fullStr | Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy |
| title_full_unstemmed | Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy |
| title_short | Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy |
| title_sort | inflammatory metal profile as a hallmark for covid 19 severity during pregnancy |
| topic | SARS – CoV – 2 placenta zinc copper IL-6 |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.935363/full |
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