Population Pharmacokinetics of Colistin Methanesulfonate Sodium and Colistin in Critically Ill Patients: A Systematic Review
Understanding the pharmacokinetics parameter of colistin methanesulfonate sodium (CMS) and colistin is needed to optimize the dosage regimen in critically ill patients. However, there is a scarcity of pharmacokinetics parameters in this population. This review provides a comprehensive understanding...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/14/9/903 |
| _version_ | 1797517628296658944 |
|---|---|
| author | Mohd Shafie Zabidi Ruzilawati Abu Bakar Nurfadhlina Musa Suzana Mustafa Wan Nazirah Wan Yusuf |
| author_facet | Mohd Shafie Zabidi Ruzilawati Abu Bakar Nurfadhlina Musa Suzana Mustafa Wan Nazirah Wan Yusuf |
| author_sort | Mohd Shafie Zabidi |
| collection | DOAJ |
| description | Understanding the pharmacokinetics parameter of colistin methanesulfonate sodium (CMS) and colistin is needed to optimize the dosage regimen in critically ill patients. However, there is a scarcity of pharmacokinetics parameters in this population. This review provides a comprehensive understanding of CMS and colistin pharmacokinetics parameters in this population. The relevant studies published in English that reported on the pharmacokinetics of CMS and colistin from 2000 until 2020 were systematically searched using the PubMed and Scopus electronic databases. Reference lists of articles were reviewed to identify additional studies. A total of 252 citation titles were identified, of which 101 potentially relevant abstracts were screened, and 25 full-text articles were selected for detailed analysis. Of those, 15 studies were included for the review. This review has demonstrated vast inter-study discrepancies in colistin plasma concentration and the pharmacokinetics parameter estimates. The discrepancies might be due to complex pathophysiological changes in the population studied, differences in CMS brand used, methodology, and study protocol. Application of loading dose of CMS and an additional dose of CMS after dialysis session was recommended by some studies. In view of inter-patient and intra-patient variability in colistin plasma concentration and pharmacokinetics parameters, personalized colistin dosing for this population is recommended. |
| first_indexed | 2024-03-10T07:19:11Z |
| format | Article |
| id | doaj.art-4a01c08ba42c43938708a1a97897085b |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T07:19:11Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-4a01c08ba42c43938708a1a97897085b2023-11-22T14:45:12ZengMDPI AGPharmaceuticals1424-82472021-09-0114990310.3390/ph14090903Population Pharmacokinetics of Colistin Methanesulfonate Sodium and Colistin in Critically Ill Patients: A Systematic ReviewMohd Shafie Zabidi0Ruzilawati Abu Bakar1Nurfadhlina Musa2Suzana Mustafa3Wan Nazirah Wan Yusuf4Department of Pharmacology, Health Campus, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, MalaysiaDepartment of Pharmacology, Health Campus, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, MalaysiaHuman Genom Centre, Health Campus, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, MalaysiaDepartment of Pharmacy, Hospital Raja Perempuan Zainab II, Kota Bharu, Kelantan 16150, MalaysiaDepartment of Pharmacology, Health Campus, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, MalaysiaUnderstanding the pharmacokinetics parameter of colistin methanesulfonate sodium (CMS) and colistin is needed to optimize the dosage regimen in critically ill patients. However, there is a scarcity of pharmacokinetics parameters in this population. This review provides a comprehensive understanding of CMS and colistin pharmacokinetics parameters in this population. The relevant studies published in English that reported on the pharmacokinetics of CMS and colistin from 2000 until 2020 were systematically searched using the PubMed and Scopus electronic databases. Reference lists of articles were reviewed to identify additional studies. A total of 252 citation titles were identified, of which 101 potentially relevant abstracts were screened, and 25 full-text articles were selected for detailed analysis. Of those, 15 studies were included for the review. This review has demonstrated vast inter-study discrepancies in colistin plasma concentration and the pharmacokinetics parameter estimates. The discrepancies might be due to complex pathophysiological changes in the population studied, differences in CMS brand used, methodology, and study protocol. Application of loading dose of CMS and an additional dose of CMS after dialysis session was recommended by some studies. In view of inter-patient and intra-patient variability in colistin plasma concentration and pharmacokinetics parameters, personalized colistin dosing for this population is recommended.https://www.mdpi.com/1424-8247/14/9/903colistin methanesulfonate sodiumcolistincritically ill patientspopulation pharmacokineticstherapeutic drug monitoring |
| spellingShingle | Mohd Shafie Zabidi Ruzilawati Abu Bakar Nurfadhlina Musa Suzana Mustafa Wan Nazirah Wan Yusuf Population Pharmacokinetics of Colistin Methanesulfonate Sodium and Colistin in Critically Ill Patients: A Systematic Review Pharmaceuticals colistin methanesulfonate sodium colistin critically ill patients population pharmacokinetics therapeutic drug monitoring |
| title | Population Pharmacokinetics of Colistin Methanesulfonate Sodium and Colistin in Critically Ill Patients: A Systematic Review |
| title_full | Population Pharmacokinetics of Colistin Methanesulfonate Sodium and Colistin in Critically Ill Patients: A Systematic Review |
| title_fullStr | Population Pharmacokinetics of Colistin Methanesulfonate Sodium and Colistin in Critically Ill Patients: A Systematic Review |
| title_full_unstemmed | Population Pharmacokinetics of Colistin Methanesulfonate Sodium and Colistin in Critically Ill Patients: A Systematic Review |
| title_short | Population Pharmacokinetics of Colistin Methanesulfonate Sodium and Colistin in Critically Ill Patients: A Systematic Review |
| title_sort | population pharmacokinetics of colistin methanesulfonate sodium and colistin in critically ill patients a systematic review |
| topic | colistin methanesulfonate sodium colistin critically ill patients population pharmacokinetics therapeutic drug monitoring |
| url | https://www.mdpi.com/1424-8247/14/9/903 |
| work_keys_str_mv | AT mohdshafiezabidi populationpharmacokineticsofcolistinmethanesulfonatesodiumandcolistinincriticallyillpatientsasystematicreview AT ruzilawatiabubakar populationpharmacokineticsofcolistinmethanesulfonatesodiumandcolistinincriticallyillpatientsasystematicreview AT nurfadhlinamusa populationpharmacokineticsofcolistinmethanesulfonatesodiumandcolistinincriticallyillpatientsasystematicreview AT suzanamustafa populationpharmacokineticsofcolistinmethanesulfonatesodiumandcolistinincriticallyillpatientsasystematicreview AT wannazirahwanyusuf populationpharmacokineticsofcolistinmethanesulfonatesodiumandcolistinincriticallyillpatientsasystematicreview |