Comparative Study Between the Efficacy of Microneedling Combined with Trichloroacetic Acid Versus Microneedling with Tacrolimus in the Treatment of Stable Vitiligo
Background: Many treatment options were used for Vitiligo. But there is no consensus on the precise treatment modality. Aim of the work: The study aimed to assess and compare the efficacy of microneedling combined with trichloracetic acid [TCA] versus micro-needling with tacrolimus in the treatmen...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Al-Azhar University, Faculty of Medicine (Damietta)
2021-04-01
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| Series: | International Journal of Medical Arts |
| Subjects: | |
| Online Access: | https://ijma.journals.ekb.eg/article_142495_ef2615a2d265f2b09c6b24496b3cd15d.pdf |
| Summary: | Background: Many treatment options were used for Vitiligo. But there is no consensus on the precise treatment modality. Aim of the work: The study aimed to assess and compare the efficacy of microneedling combined with trichloracetic acid [TCA] versus micro-needling with tacrolimus in the treatment of Vitiligo, Patients and Methods: 60 Vitiligo were included and classified into two equal groups. Group [A] included 30 patients who received micro-needling with dermapen then tacrolimus 0.03 ointments every two weeks for six sessions. Group B included thirty patients who received micro-needling with dermapen then TCA 25% every two weeks for six sessions. The outcome was documented. Results: The repigmentation was slightly higher in TCA-treated patches than with tacrolimus. Excellent response in repigmentation occurred in 43.3%of TCA patches. In contrast, in 16.7% of tacrolimus-treated patches, Good improvement occurred in13.3% of TCA-treated patches while 23.3% of tacrolimus-treated patches. Moderate improvement occurred in10.0% TCA -treated patches while 30.0% of tacrolimus-treated patches, mild improvement occurred in 13.3% of TCA -treated patches. In comparison, only in 16.7% of tacrolimus-treated patches, However, there was a great difference between the two drugs regarding erythema, inflammation, and exfoliations, which occurred mainly with TCA. Conclusion: The mix of microneedling with either TCA 25% or tacrolimus is effective and safe in treating Vitiligo. However, TCA achieved a slightly increased percentage of repigmentation than tacrolimus. |
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| ISSN: | 2636-4174 2682-3780 |