The evaluation of oxidative stress in patients with psoriasis vulgaris and atopic dermatitis by measuring the urinary level of 8‐hydroxy‐2′‐deoxyguanosine
Abstract Objectives Recent studies have revealed the relationship of oxidative stress to various medical disorders, such as cancer and ischemic heart disease. Atopic dermatitis (AD) and psoriasis vulgaris (PV) are chronic inflammatory dermatoses, and oxidative stress is presumed to be involved in th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-12-01
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| Series: | Journal of Cutaneous Immunology and Allergy |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cia2.12088 |
| _version_ | 1797334397686382592 |
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| author | Junko Shimamoto Teruo Kurokawa Hideaki Tanizaki Shinichi Moriwaki |
| author_facet | Junko Shimamoto Teruo Kurokawa Hideaki Tanizaki Shinichi Moriwaki |
| author_sort | Junko Shimamoto |
| collection | DOAJ |
| description | Abstract Objectives Recent studies have revealed the relationship of oxidative stress to various medical disorders, such as cancer and ischemic heart disease. Atopic dermatitis (AD) and psoriasis vulgaris (PV) are chronic inflammatory dermatoses, and oxidative stress is presumed to be involved in the development of these diseases as well as their becoming refractory. Methods In this study, we collected urine samples from 40 AD patients, 25 PV patients, and 39 healthy volunteers (HVs). The level of 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) in each urine sample was measured and then compared among the groups. We also evaluated the relationship between the AD and PV severity and the urinary 8‐OHdG level. Results We found that the urinary 8‐OHdG level was significantly higher in the AD and PV groups than in the HV group. We did not, however, identify an association between the 8‐OHdG level and the age, disease duration, or disease severity in the AD or PV groups. Conclusions Our results demonstrated an association between urinary 8‐OHdG and the development of AD and PV, suggesting that both are oxidative stress‐related diseases. Treatments or lifestyle improvements focused on anti‐oxidation may therefore be vital for preventing these chronic dermatoses from developing and becoming refractory. |
| first_indexed | 2024-03-08T08:19:15Z |
| format | Article |
| id | doaj.art-4a03ab0589ff4ff992171f0644bf1bb2 |
| institution | Directory Open Access Journal |
| issn | 2574-4593 |
| language | English |
| last_indexed | 2024-03-08T08:19:15Z |
| publishDate | 2019-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Journal of Cutaneous Immunology and Allergy |
| spelling | doaj.art-4a03ab0589ff4ff992171f0644bf1bb22024-02-02T06:23:46ZengFrontiers Media S.A.Journal of Cutaneous Immunology and Allergy2574-45932019-12-012616316810.1002/cia2.12088The evaluation of oxidative stress in patients with psoriasis vulgaris and atopic dermatitis by measuring the urinary level of 8‐hydroxy‐2′‐deoxyguanosineJunko Shimamoto0Teruo Kurokawa1Hideaki Tanizaki2Shinichi Moriwaki3Department of Dermatology Osaka Medical College Takatsuki JapanDepartment of Dermatology Osaka Medical College Takatsuki JapanDepartment of Dermatology Osaka Medical College Takatsuki JapanDepartment of Dermatology Osaka Medical College Takatsuki JapanAbstract Objectives Recent studies have revealed the relationship of oxidative stress to various medical disorders, such as cancer and ischemic heart disease. Atopic dermatitis (AD) and psoriasis vulgaris (PV) are chronic inflammatory dermatoses, and oxidative stress is presumed to be involved in the development of these diseases as well as their becoming refractory. Methods In this study, we collected urine samples from 40 AD patients, 25 PV patients, and 39 healthy volunteers (HVs). The level of 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) in each urine sample was measured and then compared among the groups. We also evaluated the relationship between the AD and PV severity and the urinary 8‐OHdG level. Results We found that the urinary 8‐OHdG level was significantly higher in the AD and PV groups than in the HV group. We did not, however, identify an association between the 8‐OHdG level and the age, disease duration, or disease severity in the AD or PV groups. Conclusions Our results demonstrated an association between urinary 8‐OHdG and the development of AD and PV, suggesting that both are oxidative stress‐related diseases. Treatments or lifestyle improvements focused on anti‐oxidation may therefore be vital for preventing these chronic dermatoses from developing and becoming refractory.https://doi.org/10.1002/cia2.120888‐hydroxy‐2′‐deoxyguanosineatopic dermatitisoxidative stresspsoriasis vulgaris |
| spellingShingle | Junko Shimamoto Teruo Kurokawa Hideaki Tanizaki Shinichi Moriwaki The evaluation of oxidative stress in patients with psoriasis vulgaris and atopic dermatitis by measuring the urinary level of 8‐hydroxy‐2′‐deoxyguanosine Journal of Cutaneous Immunology and Allergy 8‐hydroxy‐2′‐deoxyguanosine atopic dermatitis oxidative stress psoriasis vulgaris |
| title | The evaluation of oxidative stress in patients with psoriasis vulgaris and atopic dermatitis by measuring the urinary level of 8‐hydroxy‐2′‐deoxyguanosine |
| title_full | The evaluation of oxidative stress in patients with psoriasis vulgaris and atopic dermatitis by measuring the urinary level of 8‐hydroxy‐2′‐deoxyguanosine |
| title_fullStr | The evaluation of oxidative stress in patients with psoriasis vulgaris and atopic dermatitis by measuring the urinary level of 8‐hydroxy‐2′‐deoxyguanosine |
| title_full_unstemmed | The evaluation of oxidative stress in patients with psoriasis vulgaris and atopic dermatitis by measuring the urinary level of 8‐hydroxy‐2′‐deoxyguanosine |
| title_short | The evaluation of oxidative stress in patients with psoriasis vulgaris and atopic dermatitis by measuring the urinary level of 8‐hydroxy‐2′‐deoxyguanosine |
| title_sort | evaluation of oxidative stress in patients with psoriasis vulgaris and atopic dermatitis by measuring the urinary level of 8 hydroxy 2 deoxyguanosine |
| topic | 8‐hydroxy‐2′‐deoxyguanosine atopic dermatitis oxidative stress psoriasis vulgaris |
| url | https://doi.org/10.1002/cia2.12088 |
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