Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease
Diabetic kidney disease (DKD) is the most common diabetic complication and is a leading cause of end-stage kidney disease. Increasing evidence shows that DKD is regulated not only by many classical signaling pathways but also by epigenetic mechanisms involving chromatin histone modifications, DNA me...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2020.583528/full |
| _version_ | 1819054526054793216 |
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| author | Yue-Yu Gu Yue-Yu Gu Fu-Hua Lu Xiao-Ru Huang Xiao-Ru Huang Xiao-Ru Huang Lei Zhang Wei Mao Xue-Qing Yu Xu-Sheng Liu Hui-Yao Lan Hui-Yao Lan Hui-Yao Lan |
| author_facet | Yue-Yu Gu Yue-Yu Gu Fu-Hua Lu Xiao-Ru Huang Xiao-Ru Huang Xiao-Ru Huang Lei Zhang Wei Mao Xue-Qing Yu Xu-Sheng Liu Hui-Yao Lan Hui-Yao Lan Hui-Yao Lan |
| author_sort | Yue-Yu Gu |
| collection | DOAJ |
| description | Diabetic kidney disease (DKD) is the most common diabetic complication and is a leading cause of end-stage kidney disease. Increasing evidence shows that DKD is regulated not only by many classical signaling pathways but also by epigenetic mechanisms involving chromatin histone modifications, DNA methylation, and non-coding RNA (ncRNAs). In this review, we focus on our current understanding of the role and mechanisms of ncRNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the pathogenesis of DKD. Of them, the regulatory role of TGF-β/Smad3-dependent miRNAs and lncRNAs in DKD is highlighted. Importantly, miRNAs and lncRNAs as biomarkers and therapeutic targets for DKD are also described, and the perspective of ncRNAs as a novel therapeutic approach for combating diabetic nephropathy is also discussed. |
| first_indexed | 2024-12-21T12:53:01Z |
| format | Article |
| id | doaj.art-4a040f51a23e4077b23d3615a6c7be83 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-21T12:53:01Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-4a040f51a23e4077b23d3615a6c7be832022-12-21T19:03:26ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-01-011110.3389/fphar.2020.583528583528Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney DiseaseYue-Yu Gu0Yue-Yu Gu1Fu-Hua Lu2Xiao-Ru Huang3Xiao-Ru Huang4Xiao-Ru Huang5Lei Zhang6Wei Mao7Xue-Qing Yu8Xu-Sheng Liu9Hui-Yao Lan10Hui-Yao Lan11Hui-Yao Lan12Department of Nephrology and State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, ChinaDepartment of Nephrology and State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, ChinaGuangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Diseases, Guangdong Academy of Medical Sciences, Guangdong Provincial People’s Hospital, Guangzhou, ChinaGuangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Diseases, The Chinese University of Hong Kong, Hong Kong, ChinaDepartment of Nephrology and State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Nephrology and State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, ChinaGuangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Diseases, Guangdong Academy of Medical Sciences, Guangdong Provincial People’s Hospital, Guangzhou, ChinaDepartment of Nephrology and State Key Laboratory of Dampness Syndrome of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, ChinaDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, ChinaGuangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Diseases, Guangdong Academy of Medical Sciences, Guangdong Provincial People’s Hospital, Guangzhou, ChinaGuangdong-Hong Kong Joint Laboratory for Immunological and Genetic Kidney Diseases, The Chinese University of Hong Kong, Hong Kong, ChinaDiabetic kidney disease (DKD) is the most common diabetic complication and is a leading cause of end-stage kidney disease. Increasing evidence shows that DKD is regulated not only by many classical signaling pathways but also by epigenetic mechanisms involving chromatin histone modifications, DNA methylation, and non-coding RNA (ncRNAs). In this review, we focus on our current understanding of the role and mechanisms of ncRNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) in the pathogenesis of DKD. Of them, the regulatory role of TGF-β/Smad3-dependent miRNAs and lncRNAs in DKD is highlighted. Importantly, miRNAs and lncRNAs as biomarkers and therapeutic targets for DKD are also described, and the perspective of ncRNAs as a novel therapeutic approach for combating diabetic nephropathy is also discussed.https://www.frontiersin.org/articles/10.3389/fphar.2020.583528/fulldiabetic kidney diseasemicro RNAslong non-coding RNAsTGF-βfibrosisinflammation |
| spellingShingle | Yue-Yu Gu Yue-Yu Gu Fu-Hua Lu Xiao-Ru Huang Xiao-Ru Huang Xiao-Ru Huang Lei Zhang Wei Mao Xue-Qing Yu Xu-Sheng Liu Hui-Yao Lan Hui-Yao Lan Hui-Yao Lan Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease Frontiers in Pharmacology diabetic kidney disease micro RNAs long non-coding RNAs TGF-β fibrosis inflammation |
| title | Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease |
| title_full | Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease |
| title_fullStr | Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease |
| title_full_unstemmed | Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease |
| title_short | Non-Coding RNAs as Biomarkers and Therapeutic Targets for Diabetic Kidney Disease |
| title_sort | non coding rnas as biomarkers and therapeutic targets for diabetic kidney disease |
| topic | diabetic kidney disease micro RNAs long non-coding RNAs TGF-β fibrosis inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2020.583528/full |
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