The effect of dexamethasone on labor induction: a systematic review
Abstract Background To evaluate the effect of dexamethasone administration on the interval between initiation of labor induction and active phase of labor. Methods The databases including PubMed, Cochrane Library, Embase, Scopus and Web of Science were searched for studies published up to June 27, 2...
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | BMC Pregnancy and Childbirth |
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| Online Access: | https://doi.org/10.1186/s12884-021-04010-1 |
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| author | Zaynab Mohaghegh Shahla Faal Siahkal Hadis Bahmaei Foruzan Sharifipour Ehsan Kazemnejad Leyli Maryam Zahedian |
| author_facet | Zaynab Mohaghegh Shahla Faal Siahkal Hadis Bahmaei Foruzan Sharifipour Ehsan Kazemnejad Leyli Maryam Zahedian |
| author_sort | Zaynab Mohaghegh |
| collection | DOAJ |
| description | Abstract Background To evaluate the effect of dexamethasone administration on the interval between initiation of labor induction and active phase of labor. Methods The databases including PubMed, Cochrane Library, Embase, Scopus and Web of Science were searched for studies published up to June 27, 2021. Two types of articles were included: a) full-text articles published in English or any other languages, and b) Randomized Controlled Trials (RCTs). Participants were primi- or multigravida women with term or post-term pregnancy. The intervention group received parenteral or extra-amniotic dexamethasone whereas the control group received normal saline or no treatment before initiation of labor induction. All data were analyzed using Review Manager 5.3. Results Seventeen studies involving 1879 patients were included in the meta-analysis. Administration of dexamethasone reduced the interval between the initiation of labor induction and the beginning of active phase by about 70 min [MD: - 1.17 (− 1.37, − 1.00); P < 0.00001]. Duration of the first stage of labor in the dexamethasone group was about 88 min shorter than that in the control. There were no maternal and fetal adverse effects. Conclusions Dexamethasone could significantly reduce the length of induction-active phase interval, and length of the first stage of labor, with no difference in maternal or fetal adverse effects. |
| first_indexed | 2024-12-13T22:40:54Z |
| format | Article |
| id | doaj.art-4a0518cded504cf89589ac3799dfc9e7 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-12-13T22:40:54Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-4a0518cded504cf89589ac3799dfc9e72022-12-21T23:28:51ZengBMCBMC Pregnancy and Childbirth1471-23932021-08-0121111610.1186/s12884-021-04010-1The effect of dexamethasone on labor induction: a systematic reviewZaynab Mohaghegh0Shahla Faal Siahkal1Hadis Bahmaei2Foruzan Sharifipour3Ehsan Kazemnejad Leyli4Maryam Zahedian5Family Health Department, Health Deputy, Tehran University of Medical SciencesDepartment of Midwifery, Marand Branch, Islamic Azad UniversityDepartment of Midwifery, Ahvaz Jundishapur University of Medical SciencesDepartment of Midwifery, School of Nursing and Midwifery, Kermanshah University of Medical SciencesGuilan Road Trauma Research Center, Biostatistics Department, Guilan University of Medical SciencesLiberian of Nursing and Midwifery School, Ahvaz Jundishapur University of Medical ScienceAbstract Background To evaluate the effect of dexamethasone administration on the interval between initiation of labor induction and active phase of labor. Methods The databases including PubMed, Cochrane Library, Embase, Scopus and Web of Science were searched for studies published up to June 27, 2021. Two types of articles were included: a) full-text articles published in English or any other languages, and b) Randomized Controlled Trials (RCTs). Participants were primi- or multigravida women with term or post-term pregnancy. The intervention group received parenteral or extra-amniotic dexamethasone whereas the control group received normal saline or no treatment before initiation of labor induction. All data were analyzed using Review Manager 5.3. Results Seventeen studies involving 1879 patients were included in the meta-analysis. Administration of dexamethasone reduced the interval between the initiation of labor induction and the beginning of active phase by about 70 min [MD: - 1.17 (− 1.37, − 1.00); P < 0.00001]. Duration of the first stage of labor in the dexamethasone group was about 88 min shorter than that in the control. There were no maternal and fetal adverse effects. Conclusions Dexamethasone could significantly reduce the length of induction-active phase interval, and length of the first stage of labor, with no difference in maternal or fetal adverse effects.https://doi.org/10.1186/s12884-021-04010-1DexamethasoneLabor inductionCorticosteroidCervical ripening |
| spellingShingle | Zaynab Mohaghegh Shahla Faal Siahkal Hadis Bahmaei Foruzan Sharifipour Ehsan Kazemnejad Leyli Maryam Zahedian The effect of dexamethasone on labor induction: a systematic review BMC Pregnancy and Childbirth Dexamethasone Labor induction Corticosteroid Cervical ripening |
| title | The effect of dexamethasone on labor induction: a systematic review |
| title_full | The effect of dexamethasone on labor induction: a systematic review |
| title_fullStr | The effect of dexamethasone on labor induction: a systematic review |
| title_full_unstemmed | The effect of dexamethasone on labor induction: a systematic review |
| title_short | The effect of dexamethasone on labor induction: a systematic review |
| title_sort | effect of dexamethasone on labor induction a systematic review |
| topic | Dexamethasone Labor induction Corticosteroid Cervical ripening |
| url | https://doi.org/10.1186/s12884-021-04010-1 |
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