Depicting the Implication of miR-378a in Cancers
MicroRNA-378a (miR-378a), including miR-378a-3p and miR-378a-5p, are encoded in PPARGC1B gene. miR-378a is essential for tumorigenesis and is an independent prognostic biomarker for various malignant tumors. Aberrant expression of miR-378a affects several physiological and pathological processes, in...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-10-01
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| Series: | Technology in Cancer Research & Treatment |
| Online Access: | https://doi.org/10.1177/15330338221134385 |
| _version_ | 1828139526058409984 |
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| author | Yuelan Qin BM Renba Liang MD, PhD Pingan Lu BS Lin Lai MD, PhD Xiaodong Zhu MD, PhD |
| author_facet | Yuelan Qin BM Renba Liang MD, PhD Pingan Lu BS Lin Lai MD, PhD Xiaodong Zhu MD, PhD |
| author_sort | Yuelan Qin BM |
| collection | DOAJ |
| description | MicroRNA-378a (miR-378a), including miR-378a-3p and miR-378a-5p, are encoded in PPARGC1B gene. miR-378a is essential for tumorigenesis and is an independent prognostic biomarker for various malignant tumors. Aberrant expression of miR-378a affects several physiological and pathological processes, including proliferation, apoptosis, tumorigenesis, cancer invasion, metastasis, and therapeutic resistance. Interestingly, miR-378a has a dual functional role in either promoting or inhibiting tumorigenesis, independent of the cancer type. In this review, we comprehensively summarized the role and regulatory mechanisms of miR-378a in cancer development, hoping to provide a direction for its potential use in cancer therapy. |
| first_indexed | 2024-04-11T18:53:00Z |
| format | Article |
| id | doaj.art-4a05334bb9814069b396a10b1c5d4d52 |
| institution | Directory Open Access Journal |
| issn | 1533-0338 |
| language | English |
| last_indexed | 2024-04-11T18:53:00Z |
| publishDate | 2022-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Technology in Cancer Research & Treatment |
| spelling | doaj.art-4a05334bb9814069b396a10b1c5d4d522022-12-22T04:08:17ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382022-10-012110.1177/15330338221134385Depicting the Implication of miR-378a in CancersYuelan Qin BM0Renba Liang MD, PhD1Pingan Lu BS2Lin Lai MD, PhD3Xiaodong Zhu MD, PhD4 Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, People's Republic of China Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China Faculty of Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, People's Republic of China Key Laboratory of Early Prevention and Treatment for Regional High-Incidence-Tumor, , Ministry of Education, Nanning, People's Republic of ChinaMicroRNA-378a (miR-378a), including miR-378a-3p and miR-378a-5p, are encoded in PPARGC1B gene. miR-378a is essential for tumorigenesis and is an independent prognostic biomarker for various malignant tumors. Aberrant expression of miR-378a affects several physiological and pathological processes, including proliferation, apoptosis, tumorigenesis, cancer invasion, metastasis, and therapeutic resistance. Interestingly, miR-378a has a dual functional role in either promoting or inhibiting tumorigenesis, independent of the cancer type. In this review, we comprehensively summarized the role and regulatory mechanisms of miR-378a in cancer development, hoping to provide a direction for its potential use in cancer therapy.https://doi.org/10.1177/15330338221134385 |
| spellingShingle | Yuelan Qin BM Renba Liang MD, PhD Pingan Lu BS Lin Lai MD, PhD Xiaodong Zhu MD, PhD Depicting the Implication of miR-378a in Cancers Technology in Cancer Research & Treatment |
| title | Depicting the Implication of miR-378a in Cancers |
| title_full | Depicting the Implication of miR-378a in Cancers |
| title_fullStr | Depicting the Implication of miR-378a in Cancers |
| title_full_unstemmed | Depicting the Implication of miR-378a in Cancers |
| title_short | Depicting the Implication of miR-378a in Cancers |
| title_sort | depicting the implication of mir 378a in cancers |
| url | https://doi.org/10.1177/15330338221134385 |
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