Molecularly Imprinted Chitosan-Based Thin Films with Selectivity for Nicotine Derivatives for Application as a Bio-Sensor and Filter
This study reports the feasible use of chitosan as a thin film biosensor on the very sensitive quartz crystal micro balance system for detection of blends of multiple templates within a single matrix. The development of chitosan-based thin film materials with selectivity for nicotine derivatives is...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/13/19/3363 |
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| author | Obinna Ofoegbu David Chukwuebuka Ike Gaber El-Saber Batiha Hassan Fouad Roongnapa S. Srichana Ian Nicholls |
| author_facet | Obinna Ofoegbu David Chukwuebuka Ike Gaber El-Saber Batiha Hassan Fouad Roongnapa S. Srichana Ian Nicholls |
| author_sort | Obinna Ofoegbu |
| collection | DOAJ |
| description | This study reports the feasible use of chitosan as a thin film biosensor on the very sensitive quartz crystal micro balance system for detection of blends of multiple templates within a single matrix. The development of chitosan-based thin film materials with selectivity for nicotine derivatives is described. The molecular imprinting of a combination of nicotine derivatives in N-diacryloyl pipiradine-chitosan-methacrylic acid copolymer films on quartz crystal resonators was used to generate thin films with selectivity for nicotine and a range of nicotine analogues, particularly 3-phenylpyridine. The polymers were characterized by spectroscopic and microscopic evaluations; surface area, pore size, pore volume using Breuner-Emmet-Teller method. Temperature characteristics were also studied. The swelling and structure consistency of the Chitosan was achieved by grafting with methylmethacrylic acid and cross-linking with N-diacrylol pipiradine. A blend of 0.002 g (0.04 mmol) of Chitosan, 8.5 μL Methylmethacrylic Acid and 1.0 mg N-diacrylol pipradine (BAP) presented the best blend formulation. Detections were made within a time interval of 99 s, and blend templates were detected at a concentration of 0.5 mM from the Quartz crystal microbalance resonator analysis. The successful crosslinking of the biopolymers ensured successful control of the swelling and agglomeration of the chitosan, giving it the utility potential for use as thin film sensor. This successful crosslinking also created successful dual multiple templating on the chitosan matrix, even for aerosolized templates. The products can be used in environments with temperature ranges between 60 °C and 250 °C. |
| first_indexed | 2024-03-10T06:52:54Z |
| format | Article |
| id | doaj.art-4a063fe3b65340e3bf1b171581295d70 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T06:52:54Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-4a063fe3b65340e3bf1b171581295d702023-11-22T16:39:34ZengMDPI AGPolymers2073-43602021-09-011319336310.3390/polym13193363Molecularly Imprinted Chitosan-Based Thin Films with Selectivity for Nicotine Derivatives for Application as a Bio-Sensor and FilterObinna Ofoegbu0David Chukwuebuka Ike1Gaber El-Saber Batiha2Hassan Fouad3Roongnapa S. Srichana4Ian Nicholls5Organic, Polymer, Nano Materials and Molecular Recognition Research Group, Department of Chemistry, Joseph Sarwuan Tarka University, Makurdi 970101, NigeriaOrganic, Polymer, Nano Materials and Molecular Recognition Research Group, Department of Chemistry, Joseph Sarwuan Tarka University, Makurdi 970101, NigeriaDepartment of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, EgyptApplied Medical Science Department, Community College, King Saudi University, P.O. Box 10219, Riyadh 11433, Saudi ArabiaMolecular Recognition Materials Research Unit, Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla 90112, ThailandCentre for Biomaterials Chemistry, Linnaeus University, 39782 Kalmar, SwedenThis study reports the feasible use of chitosan as a thin film biosensor on the very sensitive quartz crystal micro balance system for detection of blends of multiple templates within a single matrix. The development of chitosan-based thin film materials with selectivity for nicotine derivatives is described. The molecular imprinting of a combination of nicotine derivatives in N-diacryloyl pipiradine-chitosan-methacrylic acid copolymer films on quartz crystal resonators was used to generate thin films with selectivity for nicotine and a range of nicotine analogues, particularly 3-phenylpyridine. The polymers were characterized by spectroscopic and microscopic evaluations; surface area, pore size, pore volume using Breuner-Emmet-Teller method. Temperature characteristics were also studied. The swelling and structure consistency of the Chitosan was achieved by grafting with methylmethacrylic acid and cross-linking with N-diacrylol pipiradine. A blend of 0.002 g (0.04 mmol) of Chitosan, 8.5 μL Methylmethacrylic Acid and 1.0 mg N-diacrylol pipradine (BAP) presented the best blend formulation. Detections were made within a time interval of 99 s, and blend templates were detected at a concentration of 0.5 mM from the Quartz crystal microbalance resonator analysis. The successful crosslinking of the biopolymers ensured successful control of the swelling and agglomeration of the chitosan, giving it the utility potential for use as thin film sensor. This successful crosslinking also created successful dual multiple templating on the chitosan matrix, even for aerosolized templates. The products can be used in environments with temperature ranges between 60 °C and 250 °C.https://www.mdpi.com/2073-4360/13/19/3363chitosangraftingmethylmethacrylic acidmolecular imprintingdual templatingthin film |
| spellingShingle | Obinna Ofoegbu David Chukwuebuka Ike Gaber El-Saber Batiha Hassan Fouad Roongnapa S. Srichana Ian Nicholls Molecularly Imprinted Chitosan-Based Thin Films with Selectivity for Nicotine Derivatives for Application as a Bio-Sensor and Filter Polymers chitosan grafting methylmethacrylic acid molecular imprinting dual templating thin film |
| title | Molecularly Imprinted Chitosan-Based Thin Films with Selectivity for Nicotine Derivatives for Application as a Bio-Sensor and Filter |
| title_full | Molecularly Imprinted Chitosan-Based Thin Films with Selectivity for Nicotine Derivatives for Application as a Bio-Sensor and Filter |
| title_fullStr | Molecularly Imprinted Chitosan-Based Thin Films with Selectivity for Nicotine Derivatives for Application as a Bio-Sensor and Filter |
| title_full_unstemmed | Molecularly Imprinted Chitosan-Based Thin Films with Selectivity for Nicotine Derivatives for Application as a Bio-Sensor and Filter |
| title_short | Molecularly Imprinted Chitosan-Based Thin Films with Selectivity for Nicotine Derivatives for Application as a Bio-Sensor and Filter |
| title_sort | molecularly imprinted chitosan based thin films with selectivity for nicotine derivatives for application as a bio sensor and filter |
| topic | chitosan grafting methylmethacrylic acid molecular imprinting dual templating thin film |
| url | https://www.mdpi.com/2073-4360/13/19/3363 |
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