Development and evaluation of candidate subunit vaccine against botulinum neurotoxin serotype B

Development and evaluation of candidate subunit vaccine against botulinum neurotoxin serotype B

Botulinum neurotoxins (BoNTs) are potential biological weapons because of their high toxicity and mortality. Vaccination is an effective strategy to prevent botulism. The carboxyl-terminus of the heavy chain (Hc domain) is nontoxic and sufficient to generate protective immune responses against natur...

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Bibliographic Details
Main Authors: Dan-Yang Shi, Bo-Yang Chen, Yun-Yun Mao, Guo Zhou, Jian-Sheng Lu, Yun-Zhou Yu, Xiao-Wei Zhou, Zhi-Wei Sun
Format: Article
Language:English
Published: Taylor & Francis Group 2019-03-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
botulinum neurotoxin
hc domain
candidate subunit vaccine
Online Access:http://dx.doi.org/10.1080/21645515.2018.1547613

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