Role of Vitamin D in Childhood Epilepsy

Background:Vitamin D is a fat-soluble vitamin and also considered a steroid hormone, that plays an important role in the proper functioning of many organs of the body.Adequate vitamin D status plays a very important role in terms of appropriate brain development and function .Regarding vitamin D,...

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Main Authors: Ahmed El-Abd Ahmed, Mohammed H. Hassan, Asmaa G. Mostafa *, Ali Helmi Bakry
Format: Article
Language:English
Published: South Valley University, Faculty of Medicine 2022-07-01
Series:SVU - International Journal of Medical Sciences
Subjects:
Online Access:https://svuijm.journals.ekb.eg/article_154646.html
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author Ahmed El-Abd Ahmed
Mohammed H. Hassan
Asmaa G. Mostafa *
Ali Helmi Bakry
author_facet Ahmed El-Abd Ahmed
Mohammed H. Hassan
Asmaa G. Mostafa *
Ali Helmi Bakry
author_sort Ahmed El-Abd Ahmed
collection DOAJ
description Background:Vitamin D is a fat-soluble vitamin and also considered a steroid hormone, that plays an important role in the proper functioning of many organs of the body.Adequate vitamin D status plays a very important role in terms of appropriate brain development and function .Regarding vitamin D,it's participation in the central nervous system's function is corroborated by the presence of the enzyme 25(OH)D3-1alpha-hydroxylase, which form of the active form of vitaminD, and the presence of receptors of vitamin D (VDR) in the brain tissue , mostly in the hypothalamus and substantia nigra. The aim of this review: is to evaluate the roleof vitamin D in childhood epilepsy and to study the vitamin D –antiepleptic drugs interactions among epileptic children. Conclusion: vitamin D insufficiency and deficiency are highly prevalent among children with epilepsy.A lot of antiepileptic drugs lower vitamin D level and lead to more seizures specially enzyme inducers' drugs.
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spelling doaj.art-4a06df072f514c54bfe966b1ab5437102022-12-22T03:00:46ZengSouth Valley University, Faculty of MedicineSVU - International Journal of Medical Sciences2735-427X2636-34022022-07-0152 410419https://dx.doi.org/10.21608/svuijm.2021.65108.1103 Role of Vitamin D in Childhood EpilepsyAhmed El-Abd Ahmed0Mohammed H. Hassan1https://orcid.org/0000-0003-2698-9438Asmaa G. Mostafa *2 Ali Helmi Bakry3Department of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt.Department of Medical Biochemistry and Molecular Biology,Faculty of Medicine, South Valley University, Qena, EgyptDepartment of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt.Department of Pediatrics, Faculty of Medicine, South Valley University, Qena, Egypt.Background:Vitamin D is a fat-soluble vitamin and also considered a steroid hormone, that plays an important role in the proper functioning of many organs of the body.Adequate vitamin D status plays a very important role in terms of appropriate brain development and function .Regarding vitamin D,it's participation in the central nervous system's function is corroborated by the presence of the enzyme 25(OH)D3-1alpha-hydroxylase, which form of the active form of vitaminD, and the presence of receptors of vitamin D (VDR) in the brain tissue , mostly in the hypothalamus and substantia nigra. The aim of this review: is to evaluate the roleof vitamin D in childhood epilepsy and to study the vitamin D –antiepleptic drugs interactions among epileptic children. Conclusion: vitamin D insufficiency and deficiency are highly prevalent among children with epilepsy.A lot of antiepileptic drugs lower vitamin D level and lead to more seizures specially enzyme inducers' drugs.https://svuijm.journals.ekb.eg/article_154646.htmlvitamin d; epilepsy; antiepileptic drugs
spellingShingle Ahmed El-Abd Ahmed
Mohammed H. Hassan
Asmaa G. Mostafa *
Ali Helmi Bakry
Role of Vitamin D in Childhood Epilepsy
SVU - International Journal of Medical Sciences
vitamin d; epilepsy; antiepileptic drugs
title Role of Vitamin D in Childhood Epilepsy
title_full Role of Vitamin D in Childhood Epilepsy
title_fullStr Role of Vitamin D in Childhood Epilepsy
title_full_unstemmed Role of Vitamin D in Childhood Epilepsy
title_short Role of Vitamin D in Childhood Epilepsy
title_sort role of vitamin d in childhood epilepsy
topic vitamin d; epilepsy; antiepileptic drugs
url https://svuijm.journals.ekb.eg/article_154646.html
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