Effect of Autologous Platelet Rich Fibrin in Human Mandibular Molar Grade II Furcation Defects- A Randomized Clinical Trial
Introduction: The Furcation of multirooted teeth is difficult region to gain access for treatment due to their complex anatomy. Modifications have been made in the periodontal instrument armamentarium to facilitate treatment of furcations. Moreover, many new materials have been introduced to att...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2017-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/9694/23277_CE[Ra1]_F(RK)_PF1(SY_PY)_PFA(NC)_PF2(SY_SS).pdf |
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| author | Syed Asimuddin Rekha Rani Koduganti Veerendra Nath Reddy Panthula Surya Prasanna Jammula Rajashree Dasari Himabindu Gireddy |
| author_facet | Syed Asimuddin Rekha Rani Koduganti Veerendra Nath Reddy Panthula Surya Prasanna Jammula Rajashree Dasari Himabindu Gireddy |
| author_sort | Syed Asimuddin |
| collection | DOAJ |
| description | Introduction: The Furcation of multirooted teeth is difficult
region to gain access for treatment due to their complex
anatomy. Modifications have been made in the periodontal
instrument armamentarium to facilitate treatment of furcations.
Moreover, many new materials have been introduced to attempt
regeneration in the furcation defects.
Aim: This study evaluated the role of Platelet Rich Fibrin (PRF)
in comparison with allograft and Guided Tissue Regeneration
(GTR) in the treatment of Grade II mandibular molar furcations.
Materials and Methods: This was a parallel arm prospective
randomized, interventional trial (NCT 02430519) conducted on
22 patients, with Grade II mandibular furcation defects. Patients
were divided into two equal groups. Group A, were treated by the
placement of PRF as a graft and as a membrane while in Group
B, the defects were treated by the placement of allograft and
Healiguide collagen membrane. Clinical parameters {Plaque Index
(PI), Probing Depth (PD), Relative Vertical Clinical Attachment
Level (RVCAL), Relative Horizontal Clinical Attachment Level
(RHCAL), Gingival Marginal Level(GML), and amount of Bonefill
using Radio-Visiography (RVGBF)}, were estimated at baseline
and nine months postoperatively. Comparison between the
groups was analysed by using independent sample t-test,
whereas, paired t-test was used to assess the mean values within
the groups.
Results: The intergroup comparison for PI, PD, RHCAL, GML,
was statistically not significant. Pertaining to RVCAL, there was a
statistically significant difference at nine months (p-value=0.04)
in Group A. Also, there was a statistically significant difference
related to RVGBF (p-value=0.006) in Group A at nine months.
Conclusion: The efficacy of PRF should be ascertained by
conducting more studies with a larger sample size, on a long
term basis, in patients with molar Grade II furcation defects. |
| first_indexed | 2024-12-13T06:36:43Z |
| format | Article |
| id | doaj.art-4a07ddd37dde487bb0bfbf679e2e902a |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-13T06:36:43Z |
| publishDate | 2017-04-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-4a07ddd37dde487bb0bfbf679e2e902a2022-12-21T23:56:29ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2017-04-01114ZC73ZC7710.7860/JCDR/2017/23277.9694Effect of Autologous Platelet Rich Fibrin in Human Mandibular Molar Grade II Furcation Defects- A Randomized Clinical TrialSyed Asimuddin0Rekha Rani Koduganti1Veerendra Nath Reddy Panthula2Surya Prasanna Jammula3Rajashree Dasari4Himabindu Gireddy5Postgraduate Student, Department of Periodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.Professor and Head, Department of Periodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.Professor, Department of Periodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.Professor, Department of Periodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.Reader, Department of Periodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.Reader, Department of Periodontics, Panineeya Mahavidhyalaya Institute of Dental Sciences and Research Centre, Hyderabad, Telangana, India.Introduction: The Furcation of multirooted teeth is difficult region to gain access for treatment due to their complex anatomy. Modifications have been made in the periodontal instrument armamentarium to facilitate treatment of furcations. Moreover, many new materials have been introduced to attempt regeneration in the furcation defects. Aim: This study evaluated the role of Platelet Rich Fibrin (PRF) in comparison with allograft and Guided Tissue Regeneration (GTR) in the treatment of Grade II mandibular molar furcations. Materials and Methods: This was a parallel arm prospective randomized, interventional trial (NCT 02430519) conducted on 22 patients, with Grade II mandibular furcation defects. Patients were divided into two equal groups. Group A, were treated by the placement of PRF as a graft and as a membrane while in Group B, the defects were treated by the placement of allograft and Healiguide collagen membrane. Clinical parameters {Plaque Index (PI), Probing Depth (PD), Relative Vertical Clinical Attachment Level (RVCAL), Relative Horizontal Clinical Attachment Level (RHCAL), Gingival Marginal Level(GML), and amount of Bonefill using Radio-Visiography (RVGBF)}, were estimated at baseline and nine months postoperatively. Comparison between the groups was analysed by using independent sample t-test, whereas, paired t-test was used to assess the mean values within the groups. Results: The intergroup comparison for PI, PD, RHCAL, GML, was statistically not significant. Pertaining to RVCAL, there was a statistically significant difference at nine months (p-value=0.04) in Group A. Also, there was a statistically significant difference related to RVGBF (p-value=0.006) in Group A at nine months. Conclusion: The efficacy of PRF should be ascertained by conducting more studies with a larger sample size, on a long term basis, in patients with molar Grade II furcation defects.https://jcdr.net/articles/PDF/9694/23277_CE[Ra1]_F(RK)_PF1(SY_PY)_PFA(NC)_PF2(SY_SS).pdfchronic periodontitisclinical parametersfurcation defectsradiographic bone fill |
| spellingShingle | Syed Asimuddin Rekha Rani Koduganti Veerendra Nath Reddy Panthula Surya Prasanna Jammula Rajashree Dasari Himabindu Gireddy Effect of Autologous Platelet Rich Fibrin in Human Mandibular Molar Grade II Furcation Defects- A Randomized Clinical Trial Journal of Clinical and Diagnostic Research chronic periodontitis clinical parameters furcation defects radiographic bone fill |
| title | Effect of Autologous Platelet Rich Fibrin in Human Mandibular Molar Grade II Furcation Defects- A Randomized Clinical Trial |
| title_full | Effect of Autologous Platelet Rich Fibrin in Human Mandibular Molar Grade II Furcation Defects- A Randomized Clinical Trial |
| title_fullStr | Effect of Autologous Platelet Rich Fibrin in Human Mandibular Molar Grade II Furcation Defects- A Randomized Clinical Trial |
| title_full_unstemmed | Effect of Autologous Platelet Rich Fibrin in Human Mandibular Molar Grade II Furcation Defects- A Randomized Clinical Trial |
| title_short | Effect of Autologous Platelet Rich Fibrin in Human Mandibular Molar Grade II Furcation Defects- A Randomized Clinical Trial |
| title_sort | effect of autologous platelet rich fibrin in human mandibular molar grade ii furcation defects a randomized clinical trial |
| topic | chronic periodontitis clinical parameters furcation defects radiographic bone fill |
| url | https://jcdr.net/articles/PDF/9694/23277_CE[Ra1]_F(RK)_PF1(SY_PY)_PFA(NC)_PF2(SY_SS).pdf |
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