Mechanisms and functions of endocytosis in T cells
Abstract Once thought of primarily as a means to neutralize pathogens or to facilitate feeding, endocytosis is now known to regulate a wide range of eukaryotic cell processes. Among these are regulation of signal transduction, mitosis, lipid homeostasis, and directed migration, among others. Less we...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-021-00766-3 |
| _version_ | 1818736797524426752 |
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| author | John C. Charpentier Philip D. King |
| author_facet | John C. Charpentier Philip D. King |
| author_sort | John C. Charpentier |
| collection | DOAJ |
| description | Abstract Once thought of primarily as a means to neutralize pathogens or to facilitate feeding, endocytosis is now known to regulate a wide range of eukaryotic cell processes. Among these are regulation of signal transduction, mitosis, lipid homeostasis, and directed migration, among others. Less well-appreciated are the roles various forms of endocytosis plays in regulating αβ and, especially, γδ T cell functions, such as T cell receptor signaling, antigen discovery by trogocytosis, and activated cell growth. Herein we examine the contribution of both clathrin-mediated and clathrin-independent mechanisms of endocytosis to T cell biology. Video Abstract |
| first_indexed | 2024-12-18T00:42:52Z |
| format | Article |
| id | doaj.art-4a080932e5604d1b98f4f49bffc791a8 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-12-18T00:42:52Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-4a080932e5604d1b98f4f49bffc791a82022-12-21T21:26:50ZengBMCCell Communication and Signaling1478-811X2021-09-0119111210.1186/s12964-021-00766-3Mechanisms and functions of endocytosis in T cellsJohn C. Charpentier0Philip D. King1Department of Microbiology and Immunology, University of Michigan Medical SchoolDepartment of Microbiology and Immunology, University of Michigan Medical SchoolAbstract Once thought of primarily as a means to neutralize pathogens or to facilitate feeding, endocytosis is now known to regulate a wide range of eukaryotic cell processes. Among these are regulation of signal transduction, mitosis, lipid homeostasis, and directed migration, among others. Less well-appreciated are the roles various forms of endocytosis plays in regulating αβ and, especially, γδ T cell functions, such as T cell receptor signaling, antigen discovery by trogocytosis, and activated cell growth. Herein we examine the contribution of both clathrin-mediated and clathrin-independent mechanisms of endocytosis to T cell biology. Video Abstracthttps://doi.org/10.1186/s12964-021-00766-3EndocytosisMacropinocytosisT lymphocytesTCR signalingCell growth |
| spellingShingle | John C. Charpentier Philip D. King Mechanisms and functions of endocytosis in T cells Cell Communication and Signaling Endocytosis Macropinocytosis T lymphocytes TCR signaling Cell growth |
| title | Mechanisms and functions of endocytosis in T cells |
| title_full | Mechanisms and functions of endocytosis in T cells |
| title_fullStr | Mechanisms and functions of endocytosis in T cells |
| title_full_unstemmed | Mechanisms and functions of endocytosis in T cells |
| title_short | Mechanisms and functions of endocytosis in T cells |
| title_sort | mechanisms and functions of endocytosis in t cells |
| topic | Endocytosis Macropinocytosis T lymphocytes TCR signaling Cell growth |
| url | https://doi.org/10.1186/s12964-021-00766-3 |
| work_keys_str_mv | AT johnccharpentier mechanismsandfunctionsofendocytosisintcells AT philipdking mechanismsandfunctionsofendocytosisintcells |