Preoperative use of anti-tumor necrosis factor therapy in Crohn's disease: promises and pitfalls
Recent advances in medical and surgical therapy were achieved during the last two decades in the management of Crohn's disease (CD). Anti-tumor necrosis factor (anti-TNF) agents are widely used worldwide. However, a significant proportion of patients still need surgical resections. The impact o...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of Intestinal Diseases
2017-04-01
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| Series: | Intestinal Research |
| Subjects: | |
| Online Access: | https://doi.org/10.5217/ir.2017.15.2.160 |
| _version_ | 1811301566872813568 |
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| author | Paulo Gustavo Kotze Subrata Ghosh Willem A. Bemelman Remo Panaccione |
| author_facet | Paulo Gustavo Kotze Subrata Ghosh Willem A. Bemelman Remo Panaccione |
| author_sort | Paulo Gustavo Kotze |
| collection | DOAJ |
| description | Recent advances in medical and surgical therapy were achieved during the last two decades in the management of Crohn's disease (CD). Anti-tumor necrosis factor (anti-TNF) agents are widely used worldwide. However, a significant proportion of patients still need surgical resections. The impact of previous exposure to these agents on the perioperative and postoperative outcomes is still controversial. In this critical review, we aimed to position the strategy of intentional preoperative use of anti-TNF agents in the management of CD. The indications and contraindications for this strategy are detailed, and despite scarce evidence, the possible advantages and disadvantages of the intentional use of anti-TNF agents before abdominal surgery in CD are discussed. |
| first_indexed | 2024-04-13T07:11:01Z |
| format | Article |
| id | doaj.art-4a097ed43021447c9b19584fa1dd9f14 |
| institution | Directory Open Access Journal |
| issn | 1598-9100 |
| language | English |
| last_indexed | 2024-04-13T07:11:01Z |
| publishDate | 2017-04-01 |
| publisher | Korean Association for the Study of Intestinal Diseases |
| record_format | Article |
| series | Intestinal Research |
| spelling | doaj.art-4a097ed43021447c9b19584fa1dd9f142022-12-22T02:56:52ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002017-04-0115216016510.5217/ir.2017.15.2.160ir.2017.15.2.160Preoperative use of anti-tumor necrosis factor therapy in Crohn's disease: promises and pitfallsPaulo Gustavo Kotze0Subrata Ghosh1Willem A. Bemelman2Remo Panaccione3Colorectal Surgery Unit, Cajuru University Hospital, Catholic University of Paraná, Curitiba, Brazil.Institute of Translational Medicine, University of Birmingham, Edgbaston, Birmingham, UK.Department of Surgery, Academic Medical Center, Amsterdam, The Netherlands.Inflammatory Bowel Disease Unit, University of Calgary, Alberta, Canada.Recent advances in medical and surgical therapy were achieved during the last two decades in the management of Crohn's disease (CD). Anti-tumor necrosis factor (anti-TNF) agents are widely used worldwide. However, a significant proportion of patients still need surgical resections. The impact of previous exposure to these agents on the perioperative and postoperative outcomes is still controversial. In this critical review, we aimed to position the strategy of intentional preoperative use of anti-TNF agents in the management of CD. The indications and contraindications for this strategy are detailed, and despite scarce evidence, the possible advantages and disadvantages of the intentional use of anti-TNF agents before abdominal surgery in CD are discussed.https://doi.org/10.5217/ir.2017.15.2.160Crohn diseaseTumor necrosis factor-alphaPreoperative care |
| spellingShingle | Paulo Gustavo Kotze Subrata Ghosh Willem A. Bemelman Remo Panaccione Preoperative use of anti-tumor necrosis factor therapy in Crohn's disease: promises and pitfalls Intestinal Research Crohn disease Tumor necrosis factor-alpha Preoperative care |
| title | Preoperative use of anti-tumor necrosis factor therapy in Crohn's disease: promises and pitfalls |
| title_full | Preoperative use of anti-tumor necrosis factor therapy in Crohn's disease: promises and pitfalls |
| title_fullStr | Preoperative use of anti-tumor necrosis factor therapy in Crohn's disease: promises and pitfalls |
| title_full_unstemmed | Preoperative use of anti-tumor necrosis factor therapy in Crohn's disease: promises and pitfalls |
| title_short | Preoperative use of anti-tumor necrosis factor therapy in Crohn's disease: promises and pitfalls |
| title_sort | preoperative use of anti tumor necrosis factor therapy in crohn s disease promises and pitfalls |
| topic | Crohn disease Tumor necrosis factor-alpha Preoperative care |
| url | https://doi.org/10.5217/ir.2017.15.2.160 |
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