Risk of Melanoma in Patients with Basal Cell Carcinoma: A Population-based Cohort Study
Basal cell carcinoma is the most prevalent cancer in Caucasians worldwide. The aim of this study was to examine the overall risk of melanoma among patients diagnosed with basal cell carcinoma. This population-based retrospective cohort study included data from January 2010 to December 2018 from the...
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| Format: | Article |
| Language: | English |
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Medical Journals Sweden
2023-01-01
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| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: | https://medicaljournalssweden.se/actadv/article/view/4402 |
| _version_ | 1797961195374772224 |
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| author | Daniella Kushnir-Grinbaum Judit Krausz Nader Rahal Liat Apel-Sarid Michael Ziv |
| author_facet | Daniella Kushnir-Grinbaum Judit Krausz Nader Rahal Liat Apel-Sarid Michael Ziv |
| author_sort | Daniella Kushnir-Grinbaum |
| collection | DOAJ |
| description | Basal cell carcinoma is the most prevalent cancer in Caucasians worldwide. The aim of this study was to examine the overall risk of melanoma among patients diagnosed with basal cell carcinoma. This population-based retrospective cohort study included data from January 2010 to December 2018 from the databases of the Clalit Health Maintenance Organization and 2 major pathology laboratories in North District, Israel. The incidence and hazard ratio of melanoma in patients with a diagnosis of basal cell carcinoma were determined. Of 466,700 participants, 51% were women and the mean (standard deviation) follow-up was 6.7 (2.9; range 1–9) years. A total of 3,338 patients were diagnosed with basal cell carcinoma during the study period, 82 of whom subsequently developed melanoma. Patients with basal cell carcinoma had a significantly higher incidence of melanoma than patients without basal cell carcinoma (2.46% vs 0.37%; p < 0.0001). Univariate Cox regression analysis revealed a hazard ratio of 6.6 (95% confidence interval: 3.6–12.1; p < 0.0001) for melanoma in patients with a diagnosis of basal cell carcinoma. In conclusion, a diagnosis of basal cell carcinoma confers a significant risk of melanoma.
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| first_indexed | 2024-04-11T00:55:19Z |
| format | Article |
| id | doaj.art-4a09c5cbf8ff4d9eaae30621fb1715b2 |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-04-11T00:55:19Z |
| publishDate | 2023-01-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-4a09c5cbf8ff4d9eaae30621fb1715b22023-01-05T05:35:05ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572023-01-0110310.2340/actadv.v103.4402Risk of Melanoma in Patients with Basal Cell Carcinoma: A Population-based Cohort StudyDaniella Kushnir-Grinbaum0Judit Krausz1Nader Rahal2Liat Apel-Sarid3Michael Ziv4Dermatology Department, Emek Medical Center, Yitshak Rabin Boulevard 21, Afula 1834111, IsraelPathology Department, Emek Medical Center, Afula, IsraelDermatology Department, Emek Medical Center, Yitshak Rabin Boulevard 21, Afula 1834111, Israel; Clalit Health Maintenance Service North District, Israel Patho-Lab Diagnostics, Assuta Medical Centers, IsraelDermatology Department, Emek Medical Center, Yitshak Rabin Boulevard 21, Afula 1834111, IsraelBasal cell carcinoma is the most prevalent cancer in Caucasians worldwide. The aim of this study was to examine the overall risk of melanoma among patients diagnosed with basal cell carcinoma. This population-based retrospective cohort study included data from January 2010 to December 2018 from the databases of the Clalit Health Maintenance Organization and 2 major pathology laboratories in North District, Israel. The incidence and hazard ratio of melanoma in patients with a diagnosis of basal cell carcinoma were determined. Of 466,700 participants, 51% were women and the mean (standard deviation) follow-up was 6.7 (2.9; range 1–9) years. A total of 3,338 patients were diagnosed with basal cell carcinoma during the study period, 82 of whom subsequently developed melanoma. Patients with basal cell carcinoma had a significantly higher incidence of melanoma than patients without basal cell carcinoma (2.46% vs 0.37%; p < 0.0001). Univariate Cox regression analysis revealed a hazard ratio of 6.6 (95% confidence interval: 3.6–12.1; p < 0.0001) for melanoma in patients with a diagnosis of basal cell carcinoma. In conclusion, a diagnosis of basal cell carcinoma confers a significant risk of melanoma. https://medicaljournalssweden.se/actadv/article/view/4402basal cell carcinomamelanomamalignant melanomaskin cancerrisk factorcohort study |
| spellingShingle | Daniella Kushnir-Grinbaum Judit Krausz Nader Rahal Liat Apel-Sarid Michael Ziv Risk of Melanoma in Patients with Basal Cell Carcinoma: A Population-based Cohort Study Acta Dermato-Venereologica basal cell carcinoma melanoma malignant melanoma skin cancer risk factor cohort study |
| title | Risk of Melanoma in Patients with Basal Cell Carcinoma: A Population-based Cohort Study |
| title_full | Risk of Melanoma in Patients with Basal Cell Carcinoma: A Population-based Cohort Study |
| title_fullStr | Risk of Melanoma in Patients with Basal Cell Carcinoma: A Population-based Cohort Study |
| title_full_unstemmed | Risk of Melanoma in Patients with Basal Cell Carcinoma: A Population-based Cohort Study |
| title_short | Risk of Melanoma in Patients with Basal Cell Carcinoma: A Population-based Cohort Study |
| title_sort | risk of melanoma in patients with basal cell carcinoma a population based cohort study |
| topic | basal cell carcinoma melanoma malignant melanoma skin cancer risk factor cohort study |
| url | https://medicaljournalssweden.se/actadv/article/view/4402 |
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