Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencing
Abstract Purpose Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) is a relatively rare subtype of DLBCL. Herein, we report a case of a patient with EBV-positive iris DLBCL after undergoing penetrating keratoplasty and discuss its possible pathogenesis. Methods A 72-year-old ma...
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| Format: | Article |
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BMC
2024-03-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-024-03334-8 |
| _version_ | 1827328160503431168 |
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| author | Xiao-na Wang Jing Hong Yong-gen Xu Pei Zhang Ying-yu Li Hong-liang Dou Hai-ping Li |
| author_facet | Xiao-na Wang Jing Hong Yong-gen Xu Pei Zhang Ying-yu Li Hong-liang Dou Hai-ping Li |
| author_sort | Xiao-na Wang |
| collection | DOAJ |
| description | Abstract Purpose Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) is a relatively rare subtype of DLBCL. Herein, we report a case of a patient with EBV-positive iris DLBCL after undergoing penetrating keratoplasty and discuss its possible pathogenesis. Methods A 72-year-old male patient presented to our hospital with progressive blurring of vision in the left eye for the past 4 months. Small white nodular lesions were observed on the iris and retinal surface of the left eye, with a white cloud-like opacity in the vitreous cavity. Results The patient was eventually diagnosed with EBV-positive iris DLBCL after undergoing pathological and metagenomic tests. After injecting methotrexate in the left vitreous cavity and administering systemic and local antiviral treatments, the ocular lesions disappeared. Conclusion EBV infection, drug immunosuppression, and aging-related immune deterioration may play significant roles in the pathogenesis of EBV-positive iris DLBCL. Synopsis Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) is a new subtype of DLBCL, which rarely occurs. Herein, we report a case of a patient with EBV-positive iris DLBCL after undergoing penetrating keratoplasty and discuss its possible pathogenesis. |
| first_indexed | 2024-03-07T15:13:56Z |
| format | Article |
| id | doaj.art-4a0a0735af9c447da6dc5022a05ccb34 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-03-07T15:13:56Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-4a0a0735af9c447da6dc5022a05ccb342024-03-05T18:02:33ZengBMCBMC Ophthalmology1471-24152024-03-012411710.1186/s12886-024-03334-8Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencingXiao-na Wang0Jing Hong1Yong-gen Xu2Pei Zhang3Ying-yu Li4Hong-liang Dou5Hai-ping Li6Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damage Ocular Nerve, Peking University Third HospitalDepartment of Ophthalmology, Beijing Key Laboratory of Restoration of Damage Ocular Nerve, Peking University Third HospitalDepartment of Ophthalmology, Beijing Key Laboratory of Restoration of Damage Ocular Nerve, Peking University Third HospitalDepartment of Ophthalmology, Beijing Key Laboratory of Restoration of Damage Ocular Nerve, Peking University Third HospitalDepartment of Ophthalmology, Beijing Key Laboratory of Restoration of Damage Ocular Nerve, Peking University Third HospitalDepartment of Ophthalmology, Beijing Key Laboratory of Restoration of Damage Ocular Nerve, Peking University Third HospitalDepartment of Ophthalmology, Beijing Key Laboratory of Restoration of Damage Ocular Nerve, Peking University Third HospitalAbstract Purpose Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) is a relatively rare subtype of DLBCL. Herein, we report a case of a patient with EBV-positive iris DLBCL after undergoing penetrating keratoplasty and discuss its possible pathogenesis. Methods A 72-year-old male patient presented to our hospital with progressive blurring of vision in the left eye for the past 4 months. Small white nodular lesions were observed on the iris and retinal surface of the left eye, with a white cloud-like opacity in the vitreous cavity. Results The patient was eventually diagnosed with EBV-positive iris DLBCL after undergoing pathological and metagenomic tests. After injecting methotrexate in the left vitreous cavity and administering systemic and local antiviral treatments, the ocular lesions disappeared. Conclusion EBV infection, drug immunosuppression, and aging-related immune deterioration may play significant roles in the pathogenesis of EBV-positive iris DLBCL. Synopsis Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) is a new subtype of DLBCL, which rarely occurs. Herein, we report a case of a patient with EBV-positive iris DLBCL after undergoing penetrating keratoplasty and discuss its possible pathogenesis.https://doi.org/10.1186/s12886-024-03334-8Epstein-Barr virusLymphomamNGS |
| spellingShingle | Xiao-na Wang Jing Hong Yong-gen Xu Pei Zhang Ying-yu Li Hong-liang Dou Hai-ping Li Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencing BMC Ophthalmology Epstein-Barr virus Lymphoma mNGS |
| title | Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencing |
| title_full | Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencing |
| title_fullStr | Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencing |
| title_full_unstemmed | Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencing |
| title_short | Epstein-Barr virus-positive iris diffuse large B-cell lymphoma detected by metagenomic next-generation sequencing |
| title_sort | epstein barr virus positive iris diffuse large b cell lymphoma detected by metagenomic next generation sequencing |
| topic | Epstein-Barr virus Lymphoma mNGS |
| url | https://doi.org/10.1186/s12886-024-03334-8 |
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