Tacrolimus toxicity in a liver-kidney transplant patient receiving Nirmatrelvir/Ritonavir for COVID-19
Due to the rapid approval of some of the newer therapies for COVID-19 infection, there are several pharmacologic aspects of these therapies that are not fully known, including drug-drug interactions. Transplant recipients face notable risks in relation to these interactions. This article outlines co...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2023-12-01
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| Series: | Romanian Medical Journal |
| Subjects: | |
| Online Access: | https://rmj.com.ro/articles/2023.4/RMJ_2023_4_Art-06.pdf |
| _version_ | 1827313188746559488 |
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| author | Santiago F. Galeano Lovera Jhonny W. Perusina Walid Haddad Karthik Gnanapandithan |
| author_facet | Santiago F. Galeano Lovera Jhonny W. Perusina Walid Haddad Karthik Gnanapandithan |
| author_sort | Santiago F. Galeano Lovera |
| collection | DOAJ |
| description | Due to the rapid approval of some of the newer therapies for COVID-19 infection, there are several pharmacologic aspects of these therapies that are not fully known, including drug-drug interactions. Transplant recipients face notable risks in relation to these interactions. This article outlines complications arising from the concurrent administration of nirmatrelvir/ritonavir and tacrolimus in a patient with history of combined kidney and liver transplantation. Additionally, it highlights the effective utilization of phenytoin as an inducer to correct the supratherapeutic levels of tacrolimus. |
| first_indexed | 2024-03-07T21:21:49Z |
| format | Article |
| id | doaj.art-4a0f3dec53c54a70bfcb71043aaea49d |
| institution | Directory Open Access Journal |
| issn | 1220-5478 2069-606X |
| language | English |
| last_indexed | 2024-04-24T21:57:43Z |
| publishDate | 2023-12-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Medical Journal |
| spelling | doaj.art-4a0f3dec53c54a70bfcb71043aaea49d2024-03-20T13:59:11ZengAmaltea Medical Publishing HouseRomanian Medical Journal1220-54782069-606X2023-12-0170418418710.37897/RMJ.2023.4.6Tacrolimus toxicity in a liver-kidney transplant patient receiving Nirmatrelvir/Ritonavir for COVID-19Santiago F. Galeano Lovera0Jhonny W. Perusina1Walid Haddad2Karthik Gnanapandithan3Department of Internal Medicine, Mayo Clinic, Jacksonville, Florida, United StatesDepartment of Clinical Research, Mayo Clinic, Jacksonville, Florida, United StatesDepartment of Clinical Research, Mayo Clinic, Jacksonville, Florida, United StatesDepartment of Internal Medicine, Mayo Clinic, Jacksonville, Florida, United StatesDue to the rapid approval of some of the newer therapies for COVID-19 infection, there are several pharmacologic aspects of these therapies that are not fully known, including drug-drug interactions. Transplant recipients face notable risks in relation to these interactions. This article outlines complications arising from the concurrent administration of nirmatrelvir/ritonavir and tacrolimus in a patient with history of combined kidney and liver transplantation. Additionally, it highlights the effective utilization of phenytoin as an inducer to correct the supratherapeutic levels of tacrolimus.https://rmj.com.ro/articles/2023.4/RMJ_2023_4_Art-06.pdfdrug interactiontacrolimuscovid-19renal transplantphenytoin |
| spellingShingle | Santiago F. Galeano Lovera Jhonny W. Perusina Walid Haddad Karthik Gnanapandithan Tacrolimus toxicity in a liver-kidney transplant patient receiving Nirmatrelvir/Ritonavir for COVID-19 Romanian Medical Journal drug interaction tacrolimus covid-19 renal transplant phenytoin |
| title | Tacrolimus toxicity in a liver-kidney transplant patient receiving Nirmatrelvir/Ritonavir for COVID-19 |
| title_full | Tacrolimus toxicity in a liver-kidney transplant patient receiving Nirmatrelvir/Ritonavir for COVID-19 |
| title_fullStr | Tacrolimus toxicity in a liver-kidney transplant patient receiving Nirmatrelvir/Ritonavir for COVID-19 |
| title_full_unstemmed | Tacrolimus toxicity in a liver-kidney transplant patient receiving Nirmatrelvir/Ritonavir for COVID-19 |
| title_short | Tacrolimus toxicity in a liver-kidney transplant patient receiving Nirmatrelvir/Ritonavir for COVID-19 |
| title_sort | tacrolimus toxicity in a liver kidney transplant patient receiving nirmatrelvir ritonavir for covid 19 |
| topic | drug interaction tacrolimus covid-19 renal transplant phenytoin |
| url | https://rmj.com.ro/articles/2023.4/RMJ_2023_4_Art-06.pdf |
| work_keys_str_mv | AT santiagofgaleanolovera tacrolimustoxicityinaliverkidneytransplantpatientreceivingnirmatrelvirritonavirforcovid19 AT jhonnywperusina tacrolimustoxicityinaliverkidneytransplantpatientreceivingnirmatrelvirritonavirforcovid19 AT walidhaddad tacrolimustoxicityinaliverkidneytransplantpatientreceivingnirmatrelvirritonavirforcovid19 AT karthikgnanapandithan tacrolimustoxicityinaliverkidneytransplantpatientreceivingnirmatrelvirritonavirforcovid19 |