Angiogenesis⁃ related factors expression in oral lichen planus
Objective To detect the expression of vascular endothelial growth factor (VEGF), intercellular adhesion molecule⁃1 (ICAM⁃1), vascular cell adhesion molecule⁃1 (VCAM⁃1) in oral lichen planus (OLP). Methods Thirty OLP patients and fifteen healthy subjects were enrolled in the study. Serum were colle...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
2017-11-01
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| Series: | 口腔疾病防治 |
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| Online Access: | http://www.kqjbfz.com/EN/10.12016/j.issn.2096-1456.2017.11.007 |
| _version_ | 1818849859338240000 |
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| author | LI Juxiong |
| author_facet | LI Juxiong |
| author_sort | LI Juxiong |
| collection | DOAJ |
| description | Objective To detect the expression of vascular endothelial growth factor (VEGF), intercellular adhesion
molecule⁃1 (ICAM⁃1), vascular cell adhesion molecule⁃1 (VCAM⁃1) in oral lichen planus (OLP). Methods Thirty OLP
patients and fifteen healthy subjects were enrolled in the study. Serum were collected from 15 healthy volunteers as con⁃
trols. Normal tissues were collected from surgical department as immunohistochemical analysis. The levels of VEGF,
ICAM ⁃1, VCAM ⁃1 in serum were measured by ELISA. Immunohistochemical analysis of VEGF, ICAM ⁃ 1, VCAM⁃1
were carried out by the means of primary antibodies and anti⁃VEGF, anti⁃CD106 antigen (VCAM⁃1) and anti⁃CD54 anti⁃
gen (ICAM⁃1). Results ELISA results showed no expression differences for VEGF between the two groups. Whereas,
the levels of ICAM⁃1, VCAM⁃1 in OLP group were significantly higher than those in control group (P < 0.05). Immuno⁃
histochemical results reveal the presence of a significant angiogenesis in OLP patients through the immunoexpression of
VEGF, ICAM⁃1, VCAM⁃1 according to the percentage of stained cells (P < 0.05). Conclusion Regarding the results,
it seems that high expression of VCAM⁃1 and ICAM⁃1 are related to oral lichen planus. |
| first_indexed | 2024-12-19T06:39:56Z |
| format | Article |
| id | doaj.art-4a10e93b2ffe47dd8121115c724b5cc5 |
| institution | Directory Open Access Journal |
| issn | 2096-1456 2096-1456 |
| language | zho |
| last_indexed | 2024-12-19T06:39:56Z |
| publishDate | 2017-11-01 |
| publisher | Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases |
| record_format | Article |
| series | 口腔疾病防治 |
| spelling | doaj.art-4a10e93b2ffe47dd8121115c724b5cc52022-12-21T20:32:06ZzhoEditorial Department of Journal of Prevention and Treatment for Stomatological Diseases口腔疾病防治2096-14562096-14562017-11-01251171271710.12016/j.issn.2096⁃1456.2017.11.007Angiogenesis⁃ related factors expression in oral lichen planusLI Juxiong0 Stomatological Hospital, Southern Medical UniversityObjective To detect the expression of vascular endothelial growth factor (VEGF), intercellular adhesion molecule⁃1 (ICAM⁃1), vascular cell adhesion molecule⁃1 (VCAM⁃1) in oral lichen planus (OLP). Methods Thirty OLP patients and fifteen healthy subjects were enrolled in the study. Serum were collected from 15 healthy volunteers as con⁃ trols. Normal tissues were collected from surgical department as immunohistochemical analysis. The levels of VEGF, ICAM ⁃1, VCAM ⁃1 in serum were measured by ELISA. Immunohistochemical analysis of VEGF, ICAM ⁃ 1, VCAM⁃1 were carried out by the means of primary antibodies and anti⁃VEGF, anti⁃CD106 antigen (VCAM⁃1) and anti⁃CD54 anti⁃ gen (ICAM⁃1). Results ELISA results showed no expression differences for VEGF between the two groups. Whereas, the levels of ICAM⁃1, VCAM⁃1 in OLP group were significantly higher than those in control group (P < 0.05). Immuno⁃ histochemical results reveal the presence of a significant angiogenesis in OLP patients through the immunoexpression of VEGF, ICAM⁃1, VCAM⁃1 according to the percentage of stained cells (P < 0.05). Conclusion Regarding the results, it seems that high expression of VCAM⁃1 and ICAM⁃1 are related to oral lichen planus.http://www.kqjbfz.com/EN/10.12016/j.issn.2096-1456.2017.11.007Oral lichen planusAngiogenesisELISAVEGFICAM⁃1VCAM⁃1 |
| spellingShingle | LI Juxiong Angiogenesis⁃ related factors expression in oral lichen planus 口腔疾病防治 Oral lichen planus Angiogenesis ELISA VEGF ICAM⁃1 VCAM⁃1 |
| title | Angiogenesis⁃ related factors expression in oral lichen planus |
| title_full | Angiogenesis⁃ related factors expression in oral lichen planus |
| title_fullStr | Angiogenesis⁃ related factors expression in oral lichen planus |
| title_full_unstemmed | Angiogenesis⁃ related factors expression in oral lichen planus |
| title_short | Angiogenesis⁃ related factors expression in oral lichen planus |
| title_sort | angiogenesis⁃ related factors expression in oral lichen planus |
| topic | Oral lichen planus Angiogenesis ELISA VEGF ICAM⁃1 VCAM⁃1 |
| url | http://www.kqjbfz.com/EN/10.12016/j.issn.2096-1456.2017.11.007 |
| work_keys_str_mv | AT lijuxiong angiogenesisrelatedfactorsexpressioninorallichenplanus |