Correlation between the Chemiluminescent Activity of Neutrophilic Granulocytes and the Lipid Peroxidation–Antioxidant Defense System in Gastric Cancer Associated with <i>Helicobacter pylori</i> Infection
Aim. To study the processes of lipid peroxidation and the activity of antioxidant defense enzymes depending on the chemiluminescent activity of neutrophilic granulocytes in patients with gastric cancer associated with <i>H. pylori</i> infection, depending on the stage. Materials and meth...
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MDPI AG
2023-07-01
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| author | Olga Valentinovna Smirnova Alexander Alexandrovich Sinyakov Eduard Vilyamovich Kasparov |
| author_facet | Olga Valentinovna Smirnova Alexander Alexandrovich Sinyakov Eduard Vilyamovich Kasparov |
| author_sort | Olga Valentinovna Smirnova |
| collection | DOAJ |
| description | Aim. To study the processes of lipid peroxidation and the activity of antioxidant defense enzymes depending on the chemiluminescent activity of neutrophilic granulocytes in patients with gastric cancer associated with <i>H. pylori</i> infection, depending on the stage. Materials and methods. A total of 39 patients with stage I–II gastric cancer and 30 patients with stage III–IV gastric cancer were examined. A study of the chemiluminescent activity of neutrophilic granulocytes was carried out and the parameters of the lipid peroxidation system and antioxidant protection in plasma were determined using the spectrophotometric method. Statistical data processing was performed using the Statistica 7.0 software package (StatSoft, St Tulsa, OK, USA). Results. In patients with gastric cancer associated with <i>H. pylori</i> infection, regardless of stage, the proportion of neutrophilic granulocytes with normal activity did not exceed 1/3 of the total number of patients, and the remaining 2/3 of patients had altered chemiluminescent activity of neutrophilic granulocytes. In patients with gastric cancer, by I–II stage of the disease, the majority revealed a reduced function of neutrophilic granulocytes, and in patients with gastric cancer in stage III–IV of the disease, the majority showed increased chemiluminescent activity of neutrophilic granulocytes. Conclusions. In all patients with gastric cancer associated with <i>H. pylori</i> infection, regardless of the stage of the disease, an increase in lipid peroxidation processes with activation of antioxidant defense enzymes was detected. At the same time, there were no statistically significant differences between the indicators of the system lipid peroxidation–antioxidant protection depending on the stage of gastric cancer and the chemiluminescent activity of neutrophilic granulocytes, which likely indicates that all reactive oxygen species produced by neutrophilic granulocytes in the respiratory burst are consumed locally, minimally affecting the development of oxidative stress in the blood plasma. |
| first_indexed | 2024-03-11T01:16:32Z |
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| language | English |
| last_indexed | 2024-03-11T01:16:32Z |
| publishDate | 2023-07-01 |
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| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-4a123db7946d416197e8b17d1961ad462023-11-18T18:28:41ZengMDPI AGBiomedicines2227-90592023-07-01117204310.3390/biomedicines11072043Correlation between the Chemiluminescent Activity of Neutrophilic Granulocytes and the Lipid Peroxidation–Antioxidant Defense System in Gastric Cancer Associated with <i>Helicobacter pylori</i> InfectionOlga Valentinovna Smirnova0Alexander Alexandrovich Sinyakov1Eduard Vilyamovich Kasparov2Federal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, St. Partizan Zheleznyaka 3 “G”, 660022 Krasnoyarsk, RussiaFederal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, St. Partizan Zheleznyaka 3 “G”, 660022 Krasnoyarsk, RussiaFederal Research Center “Krasnoyarsk Science Center” of the Siberian Branch of the Russian Academy of Sciences, Scientific Research Institute of Medical Problems of the North, St. Partizan Zheleznyaka 3 “G”, 660022 Krasnoyarsk, RussiaAim. To study the processes of lipid peroxidation and the activity of antioxidant defense enzymes depending on the chemiluminescent activity of neutrophilic granulocytes in patients with gastric cancer associated with <i>H. pylori</i> infection, depending on the stage. Materials and methods. A total of 39 patients with stage I–II gastric cancer and 30 patients with stage III–IV gastric cancer were examined. A study of the chemiluminescent activity of neutrophilic granulocytes was carried out and the parameters of the lipid peroxidation system and antioxidant protection in plasma were determined using the spectrophotometric method. Statistical data processing was performed using the Statistica 7.0 software package (StatSoft, St Tulsa, OK, USA). Results. In patients with gastric cancer associated with <i>H. pylori</i> infection, regardless of stage, the proportion of neutrophilic granulocytes with normal activity did not exceed 1/3 of the total number of patients, and the remaining 2/3 of patients had altered chemiluminescent activity of neutrophilic granulocytes. In patients with gastric cancer, by I–II stage of the disease, the majority revealed a reduced function of neutrophilic granulocytes, and in patients with gastric cancer in stage III–IV of the disease, the majority showed increased chemiluminescent activity of neutrophilic granulocytes. Conclusions. In all patients with gastric cancer associated with <i>H. pylori</i> infection, regardless of the stage of the disease, an increase in lipid peroxidation processes with activation of antioxidant defense enzymes was detected. At the same time, there were no statistically significant differences between the indicators of the system lipid peroxidation–antioxidant protection depending on the stage of gastric cancer and the chemiluminescent activity of neutrophilic granulocytes, which likely indicates that all reactive oxygen species produced by neutrophilic granulocytes in the respiratory burst are consumed locally, minimally affecting the development of oxidative stress in the blood plasma.https://www.mdpi.com/2227-9059/11/7/2043gastric cancer<i>H. pylori</i>activity of neutrophilic granulocytesoxidative stress |
| spellingShingle | Olga Valentinovna Smirnova Alexander Alexandrovich Sinyakov Eduard Vilyamovich Kasparov Correlation between the Chemiluminescent Activity of Neutrophilic Granulocytes and the Lipid Peroxidation–Antioxidant Defense System in Gastric Cancer Associated with <i>Helicobacter pylori</i> Infection Biomedicines gastric cancer <i>H. pylori</i> activity of neutrophilic granulocytes oxidative stress |
| title | Correlation between the Chemiluminescent Activity of Neutrophilic Granulocytes and the Lipid Peroxidation–Antioxidant Defense System in Gastric Cancer Associated with <i>Helicobacter pylori</i> Infection |
| title_full | Correlation between the Chemiluminescent Activity of Neutrophilic Granulocytes and the Lipid Peroxidation–Antioxidant Defense System in Gastric Cancer Associated with <i>Helicobacter pylori</i> Infection |
| title_fullStr | Correlation between the Chemiluminescent Activity of Neutrophilic Granulocytes and the Lipid Peroxidation–Antioxidant Defense System in Gastric Cancer Associated with <i>Helicobacter pylori</i> Infection |
| title_full_unstemmed | Correlation between the Chemiluminescent Activity of Neutrophilic Granulocytes and the Lipid Peroxidation–Antioxidant Defense System in Gastric Cancer Associated with <i>Helicobacter pylori</i> Infection |
| title_short | Correlation between the Chemiluminescent Activity of Neutrophilic Granulocytes and the Lipid Peroxidation–Antioxidant Defense System in Gastric Cancer Associated with <i>Helicobacter pylori</i> Infection |
| title_sort | correlation between the chemiluminescent activity of neutrophilic granulocytes and the lipid peroxidation antioxidant defense system in gastric cancer associated with i helicobacter pylori i infection |
| topic | gastric cancer <i>H. pylori</i> activity of neutrophilic granulocytes oxidative stress |
| url | https://www.mdpi.com/2227-9059/11/7/2043 |
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