Changes in SpO2 on Room Air for 34 Severe COVID-19 Patients after Ivermectin-Based Combination Treatment: 62% Normalization within 24 Hours
The emergence of COVID-19 in March 2020 challenged Zimbabwe to respond with limited medical facilities and therapeutic options. Based on early clinical indications of efficacy for the macrocyclic lactone, Ivermectin (IVM), against COVID-19, IVM-based combination treatments were deployed to treat it....
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Biologics |
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| Online Access: | https://www.mdpi.com/2673-8449/2/3/15 |
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| author | Jaqueline C. Stone Pisirai Ndarukwa David E. Scheim Barry M. Dancis Jerome Dancis Martin G. Gill Colleen Aldous |
| author_facet | Jaqueline C. Stone Pisirai Ndarukwa David E. Scheim Barry M. Dancis Jerome Dancis Martin G. Gill Colleen Aldous |
| author_sort | Jaqueline C. Stone |
| collection | DOAJ |
| description | The emergence of COVID-19 in March 2020 challenged Zimbabwe to respond with limited medical facilities and therapeutic options. Based on early clinical indications of efficacy for the macrocyclic lactone, Ivermectin (IVM), against COVID-19, IVM-based combination treatments were deployed to treat it. Oxygen saturation (SpO2) data were retrospectively analyzed for 34 severe, hypoxic COVID-19 patients all on room air (without supplemental oxygen). The patients, median age 56.5, were treated at clinics or at home between August 2020 and May 2021. All but three of these 34 patients had significantly increased SpO2 values within 24 h after the first IVM dose. The mean increase in SpO2 as a percentage of full normalization to SpO2 = 97 was 55.1% at +12 h and 62.3% at +24 h after the first IVM dose (paired <i>t</i>-test, <i>p</i> < 0.0000001). These results parallel similar sharp, rapid increases in SpO2, all on room air, for 24 mostly severe COVID-19 patients in the USA (California) who were given an IVM-based combination treatment. All patients in both of these critical series recovered. These rapid increases in SpO2 values after IVM treatment stand in sharp contrast to declines in SpO2 and associated pulmonary function through the second week following the onset of moderate or severe COVID-19 symptoms under standard care. |
| first_indexed | 2024-03-10T00:41:59Z |
| format | Article |
| id | doaj.art-4a148ef3173942e0bace4d34d8c7a008 |
| institution | Directory Open Access Journal |
| issn | 2673-8449 |
| language | English |
| last_indexed | 2024-03-10T00:41:59Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biologics |
| spelling | doaj.art-4a148ef3173942e0bace4d34d8c7a0082023-11-23T15:06:22ZengMDPI AGBiologics2673-84492022-08-012319621010.3390/biologics2030015Changes in SpO2 on Room Air for 34 Severe COVID-19 Patients after Ivermectin-Based Combination Treatment: 62% Normalization within 24 HoursJaqueline C. Stone0Pisirai Ndarukwa1David E. Scheim2Barry M. Dancis3Jerome Dancis4Martin G. Gill5Colleen Aldous6College of Primary Care Physicians of Zimbabwe, Harare, ZimbabweDepartment of Health Sciences, Bindura University of Science Education, Bindura, ZimbabweUS Public Health Service, Commissioned Corps, Inactive Reserve, Blacksburg, VA 24060, USAIndependent Researcher, Silver Spring, MD 20903, USADepartment of Mathematics, University of Maryland, College Park, MD 20742, USAENT Surgeon, Private Practice, Fourways Life Hospital, Gauteng 2191, South AfricaCollege of Health Sciences, University of KwaZulu-Natal, Durban 4041, South AfricaThe emergence of COVID-19 in March 2020 challenged Zimbabwe to respond with limited medical facilities and therapeutic options. Based on early clinical indications of efficacy for the macrocyclic lactone, Ivermectin (IVM), against COVID-19, IVM-based combination treatments were deployed to treat it. Oxygen saturation (SpO2) data were retrospectively analyzed for 34 severe, hypoxic COVID-19 patients all on room air (without supplemental oxygen). The patients, median age 56.5, were treated at clinics or at home between August 2020 and May 2021. All but three of these 34 patients had significantly increased SpO2 values within 24 h after the first IVM dose. The mean increase in SpO2 as a percentage of full normalization to SpO2 = 97 was 55.1% at +12 h and 62.3% at +24 h after the first IVM dose (paired <i>t</i>-test, <i>p</i> < 0.0000001). These results parallel similar sharp, rapid increases in SpO2, all on room air, for 24 mostly severe COVID-19 patients in the USA (California) who were given an IVM-based combination treatment. All patients in both of these critical series recovered. These rapid increases in SpO2 values after IVM treatment stand in sharp contrast to declines in SpO2 and associated pulmonary function through the second week following the onset of moderate or severe COVID-19 symptoms under standard care.https://www.mdpi.com/2673-8449/2/3/15COVID-19SARS-CoV-2spike proteinivermectindoxycyclineSpO2 |
| spellingShingle | Jaqueline C. Stone Pisirai Ndarukwa David E. Scheim Barry M. Dancis Jerome Dancis Martin G. Gill Colleen Aldous Changes in SpO2 on Room Air for 34 Severe COVID-19 Patients after Ivermectin-Based Combination Treatment: 62% Normalization within 24 Hours Biologics COVID-19 SARS-CoV-2 spike protein ivermectin doxycycline SpO2 |
| title | Changes in SpO2 on Room Air for 34 Severe COVID-19 Patients after Ivermectin-Based Combination Treatment: 62% Normalization within 24 Hours |
| title_full | Changes in SpO2 on Room Air for 34 Severe COVID-19 Patients after Ivermectin-Based Combination Treatment: 62% Normalization within 24 Hours |
| title_fullStr | Changes in SpO2 on Room Air for 34 Severe COVID-19 Patients after Ivermectin-Based Combination Treatment: 62% Normalization within 24 Hours |
| title_full_unstemmed | Changes in SpO2 on Room Air for 34 Severe COVID-19 Patients after Ivermectin-Based Combination Treatment: 62% Normalization within 24 Hours |
| title_short | Changes in SpO2 on Room Air for 34 Severe COVID-19 Patients after Ivermectin-Based Combination Treatment: 62% Normalization within 24 Hours |
| title_sort | changes in spo2 on room air for 34 severe covid 19 patients after ivermectin based combination treatment 62 normalization within 24 hours |
| topic | COVID-19 SARS-CoV-2 spike protein ivermectin doxycycline SpO2 |
| url | https://www.mdpi.com/2673-8449/2/3/15 |
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