Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila
Recent lineage tracing analyses have significantly improved our understanding of immune system development and highlighted the importance of the different hematopoietic waves. The current challenge is to understand whether these waves interact and whether this affects the function of the immune syst...
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eLife Sciences Publications Ltd
2018-07-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/34890 |
| _version_ | 1811201313562689536 |
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| author | Wael Bazzi Pierre B Cattenoz Claude Delaporte Vasanthi Dasari Rosy Sakr Yoshihiro Yuasa Angela Giangrande |
| author_facet | Wael Bazzi Pierre B Cattenoz Claude Delaporte Vasanthi Dasari Rosy Sakr Yoshihiro Yuasa Angela Giangrande |
| author_sort | Wael Bazzi |
| collection | DOAJ |
| description | Recent lineage tracing analyses have significantly improved our understanding of immune system development and highlighted the importance of the different hematopoietic waves. The current challenge is to understand whether these waves interact and whether this affects the function of the immune system. Here we report a molecular pathway regulating the immune response and involving the communication between embryonic and larval hematopoietic waves in Drosophila. Down-regulating the transcription factor Gcm specific to embryonic hematopoiesis enhances the larval phenotypes induced by over-expressing the pro-inflammatory Jak/Stat pathway or by wasp infestation. Gcm works by modulating the transduction of the Upd cytokines to the site of larval hematopoiesis and hence the response to chronic (Jak/Stat over-expression) and acute (wasp infestation) immune challenges. Thus, homeostatic interactions control the function of the immune system in physiology and pathology. Our data also indicate that a transiently expressed developmental pathway has a long-lasting effect on the immune response. |
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| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:18:49Z |
| publishDate | 2018-07-01 |
| publisher | eLife Sciences Publications Ltd |
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| spelling | doaj.art-4a14a0c8648c46d590c0e3d363c4c9d02022-12-22T03:52:10ZengeLife Sciences Publications LtdeLife2050-084X2018-07-01710.7554/eLife.34890Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in DrosophilaWael Bazzi0Pierre B Cattenoz1https://orcid.org/0000-0001-5301-1975Claude Delaporte2Vasanthi Dasari3Rosy Sakr4Yoshihiro Yuasa5Angela Giangrande6https://orcid.org/0000-0001-6278-5120Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; UMR7104, Centre National de la Recherche Scientifique, Illkirch, France; U1258, Institut National de la Santé et de la Recherche Médicale, Illkirch, France; Université de Strasbourg, Illkirch, FranceInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; UMR7104, Centre National de la Recherche Scientifique, Illkirch, France; U1258, Institut National de la Santé et de la Recherche Médicale, Illkirch, France; Université de Strasbourg, Illkirch, FranceInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; UMR7104, Centre National de la Recherche Scientifique, Illkirch, France; U1258, Institut National de la Santé et de la Recherche Médicale, Illkirch, France; Université de Strasbourg, Illkirch, FranceInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; UMR7104, Centre National de la Recherche Scientifique, Illkirch, France; U1258, Institut National de la Santé et de la Recherche Médicale, Illkirch, France; Université de Strasbourg, Illkirch, FranceInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; UMR7104, Centre National de la Recherche Scientifique, Illkirch, France; U1258, Institut National de la Santé et de la Recherche Médicale, Illkirch, France; Université de Strasbourg, Illkirch, FranceInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; UMR7104, Centre National de la Recherche Scientifique, Illkirch, France; U1258, Institut National de la Santé et de la Recherche Médicale, Illkirch, France; Université de Strasbourg, Illkirch, FranceInstitut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France; UMR7104, Centre National de la Recherche Scientifique, Illkirch, France; U1258, Institut National de la Santé et de la Recherche Médicale, Illkirch, France; Université de Strasbourg, Illkirch, FranceRecent lineage tracing analyses have significantly improved our understanding of immune system development and highlighted the importance of the different hematopoietic waves. The current challenge is to understand whether these waves interact and whether this affects the function of the immune system. Here we report a molecular pathway regulating the immune response and involving the communication between embryonic and larval hematopoietic waves in Drosophila. Down-regulating the transcription factor Gcm specific to embryonic hematopoiesis enhances the larval phenotypes induced by over-expressing the pro-inflammatory Jak/Stat pathway or by wasp infestation. Gcm works by modulating the transduction of the Upd cytokines to the site of larval hematopoiesis and hence the response to chronic (Jak/Stat over-expression) and acute (wasp infestation) immune challenges. Thus, homeostatic interactions control the function of the immune system in physiology and pathology. Our data also indicate that a transiently expressed developmental pathway has a long-lasting effect on the immune response.https://elifesciences.org/articles/34890DrosophilahematopoiesisJAK/STATinflammationtranscription factorsGcm |
| spellingShingle | Wael Bazzi Pierre B Cattenoz Claude Delaporte Vasanthi Dasari Rosy Sakr Yoshihiro Yuasa Angela Giangrande Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila eLife Drosophila hematopoiesis JAK/STAT inflammation transcription factors Gcm |
| title | Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila |
| title_full | Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila |
| title_fullStr | Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila |
| title_full_unstemmed | Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila |
| title_short | Embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in Drosophila |
| title_sort | embryonic hematopoiesis modulates the inflammatory response and larval hematopoiesis in drosophila |
| topic | Drosophila hematopoiesis JAK/STAT inflammation transcription factors Gcm |
| url | https://elifesciences.org/articles/34890 |
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