Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma
Oral cancer often presents with aggressive behavior and a high risk of recurrence and metastasis. For oral squamous cell carcinoma (OSCC), which is the most frequent histological subtype, therapy strategies include surgery, radiation therapy, chemotherapy, immune checkpoint inhibitors, and EGFR inhi...
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MDPI AG
2021-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/1/87 |
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| author | Ramona Erber Steffen Spoerl Andreas Mamilos Rosemarie Krupar Arndt Hartmann Matthias Ruebner Juergen Taxis Mareike Wittenberg Torsten E. Reichert Gerrit Spanier Silvia Spoerl |
| author_facet | Ramona Erber Steffen Spoerl Andreas Mamilos Rosemarie Krupar Arndt Hartmann Matthias Ruebner Juergen Taxis Mareike Wittenberg Torsten E. Reichert Gerrit Spanier Silvia Spoerl |
| author_sort | Ramona Erber |
| collection | DOAJ |
| description | Oral cancer often presents with aggressive behavior and a high risk of recurrence and metastasis. For oral squamous cell carcinoma (OSCC), which is the most frequent histological subtype, therapy strategies include surgery, radiation therapy, chemotherapy, immune checkpoint inhibitors, and EGFR inhibitors. Recently, a Trop-2 antibody-drug conjugate (ADC) has been approved in the United States of America for the treatment of advanced triple-negative breast cancer. However, this ADC has also been tested in other solid tumors including head & neck squamous cell carcinoma. The prognostic impact of Trop-2 has already been reported for several cancers. We studied the prognostic influence of Trop-2 protein expression on OSCC patients’ survival. The cohort comprised <i>n</i> = 229 OSCC patients with available archived tumor tissue and corresponding non-neoplastic oral mucosa tissue. Using immunohistochemistry, we investigated Trop-2 expression in both the central and peripheral regions of each tumor and in corresponding non-neoplastic oral mucosa. In patients suffering from OSCC with combined high central and low peripheral Trop-2 expression, five-year overall survival (OS) was 41.2%, whereas 55.6% of OSCC patients who presented lower central and/or higher peripheral tumoral Trop-2 expression were alive after five years (<i>p</i> = 0.075). In multivariate Cox regression, the expression pattern of high central tumoral and lower peripheral Trop-2 expression was significantly correlated with impaired OS (HR = 1.802, 95%-CI: 1.134–2.864; <i>p</i> = 0.013) and recurrence-free survival (RFS) (HR = 1.633, 95%-CI: 1.042–2.560; <i>p</i> = 0.033), respectively, when adjusting for co-variables. Hence, Trop-2 may serve as an independent prognostic biomarker in OSCC. In subsequent studies, the pathophysiological meaning of downregulated Trop-2 expression in the OSCC periphery has to be analyzed. |
| first_indexed | 2024-03-10T03:40:24Z |
| format | Article |
| id | doaj.art-4a167e669105408091ff22145c5d7542 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T03:40:24Z |
| publishDate | 2021-12-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4a167e669105408091ff22145c5d75422023-11-23T11:34:25ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-12-012318710.3390/ijms23010087Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell CarcinomaRamona Erber0Steffen Spoerl1Andreas Mamilos2Rosemarie Krupar3Arndt Hartmann4Matthias Ruebner5Juergen Taxis6Mareike Wittenberg7Torsten E. Reichert8Gerrit Spanier9Silvia Spoerl10Institute of Pathology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, GermanyDepartment of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93042 Regensburg, GermanyInstitute of Pathology, University Hospital Regensburg, 93042 Regensburg, GermanyInstitute of Pathology, University Hospital Regensburg, 93042 Regensburg, GermanyInstitute of Pathology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, GermanyDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, GermanyDepartment of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93042 Regensburg, GermanyDepartment of Internal Medicine 5, Hematology/Oncology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, GermanyDepartment of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93042 Regensburg, GermanyDepartment of Cranio-Maxillofacial Surgery, University Hospital Regensburg, 93042 Regensburg, GermanyDepartment of Internal Medicine 5, Hematology/Oncology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Comprehensive Cancer Center Erlangen-EMN, 91054 Erlangen, GermanyOral cancer often presents with aggressive behavior and a high risk of recurrence and metastasis. For oral squamous cell carcinoma (OSCC), which is the most frequent histological subtype, therapy strategies include surgery, radiation therapy, chemotherapy, immune checkpoint inhibitors, and EGFR inhibitors. Recently, a Trop-2 antibody-drug conjugate (ADC) has been approved in the United States of America for the treatment of advanced triple-negative breast cancer. However, this ADC has also been tested in other solid tumors including head & neck squamous cell carcinoma. The prognostic impact of Trop-2 has already been reported for several cancers. We studied the prognostic influence of Trop-2 protein expression on OSCC patients’ survival. The cohort comprised <i>n</i> = 229 OSCC patients with available archived tumor tissue and corresponding non-neoplastic oral mucosa tissue. Using immunohistochemistry, we investigated Trop-2 expression in both the central and peripheral regions of each tumor and in corresponding non-neoplastic oral mucosa. In patients suffering from OSCC with combined high central and low peripheral Trop-2 expression, five-year overall survival (OS) was 41.2%, whereas 55.6% of OSCC patients who presented lower central and/or higher peripheral tumoral Trop-2 expression were alive after five years (<i>p</i> = 0.075). In multivariate Cox regression, the expression pattern of high central tumoral and lower peripheral Trop-2 expression was significantly correlated with impaired OS (HR = 1.802, 95%-CI: 1.134–2.864; <i>p</i> = 0.013) and recurrence-free survival (RFS) (HR = 1.633, 95%-CI: 1.042–2.560; <i>p</i> = 0.033), respectively, when adjusting for co-variables. Hence, Trop-2 may serve as an independent prognostic biomarker in OSCC. In subsequent studies, the pathophysiological meaning of downregulated Trop-2 expression in the OSCC periphery has to be analyzed.https://www.mdpi.com/1422-0067/23/1/87Trop-2TACSTD2tumor associated calcium signal transducer 2oral squamous cell carcinomaprognosisantibody-drug conjugates |
| spellingShingle | Ramona Erber Steffen Spoerl Andreas Mamilos Rosemarie Krupar Arndt Hartmann Matthias Ruebner Juergen Taxis Mareike Wittenberg Torsten E. Reichert Gerrit Spanier Silvia Spoerl Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma International Journal of Molecular Sciences Trop-2 TACSTD2 tumor associated calcium signal transducer 2 oral squamous cell carcinoma prognosis antibody-drug conjugates |
| title | Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma |
| title_full | Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma |
| title_fullStr | Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma |
| title_short | Impact of Spatially Heterogeneous Trop-2 Expression on Prognosis in Oral Squamous Cell Carcinoma |
| title_sort | impact of spatially heterogeneous trop 2 expression on prognosis in oral squamous cell carcinoma |
| topic | Trop-2 TACSTD2 tumor associated calcium signal transducer 2 oral squamous cell carcinoma prognosis antibody-drug conjugates |
| url | https://www.mdpi.com/1422-0067/23/1/87 |
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