Brucella abortus modulates macrophage polarization and inflammatory response by targeting glutaminases through the NF-κB signaling pathway

Brucella abortus modulates macrophage polarization and inflammatory response by targeting glutaminases through the NF-κB signaling pathway

ObjectivesThe mechanism of Brucella infection regulating macrophage phenotype has not been completely elucidated until now. This study aimed to determine the mechanism of Brucella abortus in the modulation of macrophage phenotype using RAW264.7 cells as a model.Materials and methodsRT-qPCR, ELISA an...

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Bibliografski detalji
Glavni autori: Tianyi Zhao, Zedan Zhang, Yitao Li, Zhihua Sun, Liangbo Liu, Xingmei Deng, Jia Guo, Dexin Zhu, Shuzhu Cao, Yingjin Chai, Usevich Vera Nikolaevna, Suleimenov Maratbek, Zhen Wang, Hui Zhang
Format: Članak
Jezik:English
Izdano: Frontiers Media S.A. 2023-05-01
Serija:Frontiers in Immunology
Teme:
Brucella abortus
cell polarization
NF-κB
ChIP-seq
glutaminase
Online pristup:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1180837/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1180837/full

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