Systematic analysis of prognostic and immunologic characteristics associated with coronavirus disease 2019 regulators in acute myeloid leukemia
The coronavirus disease 2019 (COVID-19) pandemic has so far damaged the health of millions and has made the treatment of cancer patients more complicated, and so did acute myeloid leukemia (AML). The current problem is the lack of understanding of their interactions and suggestions of evidence-based...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.959109/full |
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| author | Mingjie Shi Mingjie Shi Lidan Chen Yue Wei Riling Chen Riling Chen Riling Chen Runmin Guo Runmin Guo Fei Luo Fei Luo Fei Luo |
| author_facet | Mingjie Shi Mingjie Shi Lidan Chen Yue Wei Riling Chen Riling Chen Riling Chen Runmin Guo Runmin Guo Fei Luo Fei Luo Fei Luo |
| author_sort | Mingjie Shi |
| collection | DOAJ |
| description | The coronavirus disease 2019 (COVID-19) pandemic has so far damaged the health of millions and has made the treatment of cancer patients more complicated, and so did acute myeloid leukemia (AML). The current problem is the lack of understanding of their interactions and suggestions of evidence-based guidelines or historical experience for the treatment of such patients. Here, we first identified the COVID-19-related differentially expressed genes (C-DEGs) in AML patients by analyzing RNA-seq from public databases and explored their enrichment pathways and candidate drugs. A total of 76 C-DEGs associated with the progress of AML and COVID-19 infection were ultimately identified, and the functional analysis suggested that there are some shared links between them. Their protein–protein interactions (PPIs) and protein–drug interactions were then recognized by multiple bioinformatics algorithms. Moreover, a COVID-19 gene-associated prognostic model (C-GPM) with riskScore was constructed, patients with a high riskScore had poor survival and apparently immune-activated phenotypes, such as stronger monocyte and neutrophil cell infiltrations and higher immunosuppressants targeting expressions, meaning which may be one of the common denominators between COVID-19 and AML and the reason what complicates the treatment of the latter. Among the study’s drawbacks is that these results relied heavily on publicly available datasets rather than being clinically confirmed. Yet, these findings visualized those C-DEGs’ enrichment pathways and inner associations, and the C-GPM based on them could accurately predict survival outcomes in AML patients, which will be helpful for further optimizing therapies for AML patients with COVID-19 infections. |
| first_indexed | 2024-04-12T18:43:13Z |
| format | Article |
| id | doaj.art-4a1b05c2f02d43a0910f46fe5912856a |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-12T18:43:13Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-4a1b05c2f02d43a0910f46fe5912856a2022-12-22T03:20:42ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-09-011310.3389/fgene.2022.959109959109Systematic analysis of prognostic and immunologic characteristics associated with coronavirus disease 2019 regulators in acute myeloid leukemiaMingjie Shi0Mingjie Shi1Lidan Chen2Yue Wei3Riling Chen4Riling Chen5Riling Chen6Runmin Guo7Runmin Guo8Fei Luo9Fei Luo10Fei Luo11Key Laboratory of Research in Maternal and Child Medicine and Birth Defects, Guangdong Medical University, Foshan, ChinaMatenal and Child Research Institute, Shunde Women and Children’s Hospital (Maternity andChild Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, ChinaFirst College of Clinical Medicine, Guangdong Medical University, Zhanjiang, ChinaDepartment of Ultrasound, Shunde Women and Children’s Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, ChinaKey Laboratory of Research in Maternal and Child Medicine and Birth Defects, Guangdong Medical University, Foshan, ChinaMatenal and Child Research Institute, Shunde Women and Children’s Hospital (Maternity andChild Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, ChinaDepartment of Hematology-Oncology, Shunde Women and Children’s Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, ChinaKey Laboratory of Research in Maternal and Child Medicine and Birth Defects, Guangdong Medical University, Foshan, ChinaMatenal and Child Research Institute, Shunde Women and Children’s Hospital (Maternity andChild Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, ChinaKey Laboratory of Research in Maternal and Child Medicine and Birth Defects, Guangdong Medical University, Foshan, ChinaMatenal and Child Research Institute, Shunde Women and Children’s Hospital (Maternity andChild Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, ChinaDepartment of Hematology-Oncology, Shunde Women and Children’s Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, ChinaThe coronavirus disease 2019 (COVID-19) pandemic has so far damaged the health of millions and has made the treatment of cancer patients more complicated, and so did acute myeloid leukemia (AML). The current problem is the lack of understanding of their interactions and suggestions of evidence-based guidelines or historical experience for the treatment of such patients. Here, we first identified the COVID-19-related differentially expressed genes (C-DEGs) in AML patients by analyzing RNA-seq from public databases and explored their enrichment pathways and candidate drugs. A total of 76 C-DEGs associated with the progress of AML and COVID-19 infection were ultimately identified, and the functional analysis suggested that there are some shared links between them. Their protein–protein interactions (PPIs) and protein–drug interactions were then recognized by multiple bioinformatics algorithms. Moreover, a COVID-19 gene-associated prognostic model (C-GPM) with riskScore was constructed, patients with a high riskScore had poor survival and apparently immune-activated phenotypes, such as stronger monocyte and neutrophil cell infiltrations and higher immunosuppressants targeting expressions, meaning which may be one of the common denominators between COVID-19 and AML and the reason what complicates the treatment of the latter. Among the study’s drawbacks is that these results relied heavily on publicly available datasets rather than being clinically confirmed. Yet, these findings visualized those C-DEGs’ enrichment pathways and inner associations, and the C-GPM based on them could accurately predict survival outcomes in AML patients, which will be helpful for further optimizing therapies for AML patients with COVID-19 infections.https://www.frontiersin.org/articles/10.3389/fgene.2022.959109/fullacute myeloid leukemiaCOVID-19differentially expressed genesprognosisdrug moleculeprotein–protein interaction |
| spellingShingle | Mingjie Shi Mingjie Shi Lidan Chen Yue Wei Riling Chen Riling Chen Riling Chen Runmin Guo Runmin Guo Fei Luo Fei Luo Fei Luo Systematic analysis of prognostic and immunologic characteristics associated with coronavirus disease 2019 regulators in acute myeloid leukemia Frontiers in Genetics acute myeloid leukemia COVID-19 differentially expressed genes prognosis drug molecule protein–protein interaction |
| title | Systematic analysis of prognostic and immunologic characteristics associated with coronavirus disease 2019 regulators in acute myeloid leukemia |
| title_full | Systematic analysis of prognostic and immunologic characteristics associated with coronavirus disease 2019 regulators in acute myeloid leukemia |
| title_fullStr | Systematic analysis of prognostic and immunologic characteristics associated with coronavirus disease 2019 regulators in acute myeloid leukemia |
| title_full_unstemmed | Systematic analysis of prognostic and immunologic characteristics associated with coronavirus disease 2019 regulators in acute myeloid leukemia |
| title_short | Systematic analysis of prognostic and immunologic characteristics associated with coronavirus disease 2019 regulators in acute myeloid leukemia |
| title_sort | systematic analysis of prognostic and immunologic characteristics associated with coronavirus disease 2019 regulators in acute myeloid leukemia |
| topic | acute myeloid leukemia COVID-19 differentially expressed genes prognosis drug molecule protein–protein interaction |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.959109/full |
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