Degradation of ciprofloxacin in aqueous solution using ozone microbubbles: spectroscopic, kinetics, and antibacterial analysis
Ciprofloxacin (CIP) has been listed in the last version of the surface water due to its ability to kill human cells by inhibiting the activity of DNA topoisomerase IV. Thus, CIP, along with other antibiotic pollution has become a serious threat to the environment and public health. Ozonation has bee...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022014256 |
| _version_ | 1818472742610010112 |
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| author | Sera Budi Verinda Muflihatul Muniroh Eko Yulianto Nani Maharani Gunawan Gunawan Nur Farida Amalia Jonathan Hobley Anwar Usman Muhammad Nur |
| author_facet | Sera Budi Verinda Muflihatul Muniroh Eko Yulianto Nani Maharani Gunawan Gunawan Nur Farida Amalia Jonathan Hobley Anwar Usman Muhammad Nur |
| author_sort | Sera Budi Verinda |
| collection | DOAJ |
| description | Ciprofloxacin (CIP) has been listed in the last version of the surface water due to its ability to kill human cells by inhibiting the activity of DNA topoisomerase IV. Thus, CIP, along with other antibiotic pollution has become a serious threat to the environment and public health. Ozonation has been used as an advanced technique that is applied in wastewater treatment to remove CIP, but the primary limitation of this method is the low solubility of ozone in water. This study is the first report of CIP removal in a scale-up of its aqueous solution using a self-developed aerator pump-enhanced ozonation (APO) system, which only employs a propeller and a zigzag arrangement of meshes. This aerator pump decreased the size of ozone bubbles by 90% and increased the effective ozone solubility to 0.47 ppm. The mechanism of degradation of CIP is attributed to an oxidation reaction of the antibiotic with reactive oxygen species, such as hydroxyl, oxygen, and hydroperoxyl radicals, generated on the surface of the ozone microbubbles. It was found that the rate and efficiency of degradation of CIP using the APO system were 3.64 × 10−3/min and 83.5%, respectively, which is higher compared with those of conventional flow ozonation (FO) systems (1.47 × 10−3/min and 60.9%). The higher degradation efficiency of CIP by the APO system was also revealed by its higher electrical energy efficiency (0.146 g/kWh), compared to that of the FO system (0.106 g/kWh). The degradation of CIP was also monitored by the resulting antibacterial activity against Escherichia coli and Staphylococcus aureus. |
| first_indexed | 2024-04-14T04:12:54Z |
| format | Article |
| id | doaj.art-4a1b762cf3874e74b97e06aa726dd63e |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-14T04:12:54Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-4a1b762cf3874e74b97e06aa726dd63e2022-12-22T02:13:04ZengElsevierHeliyon2405-84402022-08-0188e10137Degradation of ciprofloxacin in aqueous solution using ozone microbubbles: spectroscopic, kinetics, and antibacterial analysisSera Budi Verinda0Muflihatul Muniroh1Eko Yulianto2Nani Maharani3Gunawan Gunawan4Nur Farida Amalia5Jonathan Hobley6Anwar Usman7Muhammad Nur8Biomedical Graduate Program, Faculty of Medicine, Universitas Diponegoro, Tembalang, Semarang 50275, IndonesiaDepartment of Physiology, Faculty of Medicine, Universitas Diponegoro, Tembalang, Semarang 50275, IndonesiaCenter for Plasma Research, Integrated Laboratory, Universitas Diponegoro, Tembalang, Semarang 50275, IndonesiaDepartment of Pharmacology and Therapy, Faculty of Medicine, Universitas Diponegoro, Tembalang, Semarang 50275, IndonesiaDepartment of Chemistry, Faculty of Science and Mathematics, Universitas Diponegoro, Tembalang, Semarang 50275, IndonesiaDepartment of Physics, Faculty of Science and Mathematics, Universitas Diponegoro, Tembalang, Semarang 50275, IndonesiaDepartment of Biomedical Engineering, National Cheng Kung University, No. 1 University Road, Tainan City 701, TaiwanDepartment of Chemistry, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE1410, BruneiCenter for Plasma Research, Integrated Laboratory, Universitas Diponegoro, Tembalang, Semarang 50275, Indonesia; Department of Physics, Faculty of Science and Mathematics, Universitas Diponegoro, Tembalang, Semarang 50275, Indonesia; Corresponding author.Ciprofloxacin (CIP) has been listed in the last version of the surface water due to its ability to kill human cells by inhibiting the activity of DNA topoisomerase IV. Thus, CIP, along with other antibiotic pollution has become a serious threat to the environment and public health. Ozonation has been used as an advanced technique that is applied in wastewater treatment to remove CIP, but the primary limitation of this method is the low solubility of ozone in water. This study is the first report of CIP removal in a scale-up of its aqueous solution using a self-developed aerator pump-enhanced ozonation (APO) system, which only employs a propeller and a zigzag arrangement of meshes. This aerator pump decreased the size of ozone bubbles by 90% and increased the effective ozone solubility to 0.47 ppm. The mechanism of degradation of CIP is attributed to an oxidation reaction of the antibiotic with reactive oxygen species, such as hydroxyl, oxygen, and hydroperoxyl radicals, generated on the surface of the ozone microbubbles. It was found that the rate and efficiency of degradation of CIP using the APO system were 3.64 × 10−3/min and 83.5%, respectively, which is higher compared with those of conventional flow ozonation (FO) systems (1.47 × 10−3/min and 60.9%). The higher degradation efficiency of CIP by the APO system was also revealed by its higher electrical energy efficiency (0.146 g/kWh), compared to that of the FO system (0.106 g/kWh). The degradation of CIP was also monitored by the resulting antibacterial activity against Escherichia coli and Staphylococcus aureus.http://www.sciencedirect.com/science/article/pii/S2405844022014256CiprofloxacinAntibiotic contaminantsDegradationOzoneMicrobubbles |
| spellingShingle | Sera Budi Verinda Muflihatul Muniroh Eko Yulianto Nani Maharani Gunawan Gunawan Nur Farida Amalia Jonathan Hobley Anwar Usman Muhammad Nur Degradation of ciprofloxacin in aqueous solution using ozone microbubbles: spectroscopic, kinetics, and antibacterial analysis Heliyon Ciprofloxacin Antibiotic contaminants Degradation Ozone Microbubbles |
| title | Degradation of ciprofloxacin in aqueous solution using ozone microbubbles: spectroscopic, kinetics, and antibacterial analysis |
| title_full | Degradation of ciprofloxacin in aqueous solution using ozone microbubbles: spectroscopic, kinetics, and antibacterial analysis |
| title_fullStr | Degradation of ciprofloxacin in aqueous solution using ozone microbubbles: spectroscopic, kinetics, and antibacterial analysis |
| title_full_unstemmed | Degradation of ciprofloxacin in aqueous solution using ozone microbubbles: spectroscopic, kinetics, and antibacterial analysis |
| title_short | Degradation of ciprofloxacin in aqueous solution using ozone microbubbles: spectroscopic, kinetics, and antibacterial analysis |
| title_sort | degradation of ciprofloxacin in aqueous solution using ozone microbubbles spectroscopic kinetics and antibacterial analysis |
| topic | Ciprofloxacin Antibiotic contaminants Degradation Ozone Microbubbles |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022014256 |
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