Effects of systemic administration of ciliary neurotrophic factor on Bax and Bcl-2 proteins in the lumbar spinal cord of neonatal rats after sciatic nerve transection

Effects of systemic administration of ciliary neurotrophic factor on Bax and Bcl-2 proteins in the lumbar spinal cord of neonatal rats after sciatic nerve transection

Ciliary neurotrophic factor (CNTF) is a cytokine that plays a neuroprotective role in relation to axotomized motoneurons. We determined the effect of daily subcutaneous doses of CNTF (1.2 µg/g for 5 days; N = 13) or PBS (N = 13) on the levels of mRNA for Bcl-2 and Bax, as well as the expression and...

Full description

Bibliographic Details
Main Authors:	A.C.S. Rezende, A.S. Vieira, F. Rogério, L.F. Rezende, A.C. Boschero, A. Negro, F. Langone
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica 2008-11-01
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	Ciliary neurotrophic factor Bax Neonatal rats Axotomy Motoneuron Immunoprecipitation
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001100013

Similar Items

Mechanical stimulation of paralyzed vibrissal muscles following facial nerve injury in adult rat promotes full recovery of whisking
by: Doychin N. Angelov, et al.
Published: (2007-04-01)

Effects of sciatic nerve transection on ultrastructure, NADPH-diaphorase reaction and serotonin-, tyrosine hydroxylase-, c-Fos-, glucose transporter 1- and 3-like immunoreactivities in frog dorsal root ganglion
by: F. Rigon, et al.
Published: (2013-06-01)

Effects of sciatic nerve transection on ultrastructure, NADPH-diaphorase reaction and serotonin-, tyrosine hydroxylase-, c-Fos-, glucose transporter 1- and 3-like immunoreactivities in frog dorsal root ganglion
by: F. Rigon, et al.
Published: (2013-01-01)

The Role of Microglia in Neuroinflammation of the Spinal Cord after Peripheral Nerve Injury
by: Tana S. Pottorf, et al.
Published: (2022-06-01)

Synaptic Plasticity on Motoneurons After Axotomy: A Necessary Change in Paradigm
by: Francisco J. Alvarez, et al.
Published: (2020-04-01)

Genetically determined susceptibility to neurodegeneration is associated with expression of inflammatory genes
by: Maria Swanberg, et al.
Published: (2006-10-01)

Neuroprotective Effect of Vascular Endothelial Growth Factor on Motoneurons of the Oculomotor System
by: Silvia Silva-Hucha, et al.
Published: (2021-01-01)

Events Occurring in the Axotomized Facial Nucleus
by: Kazuyuki Nakajima, et al.
Published: (2022-06-01)

Trigeminal Sensory Supply Is Essential for Motor Recovery after Facial Nerve Injury
by: Svenja Rink-Notzon, et al.
Published: (2022-12-01)

CD4+ T cell expression of the IL-10 receptor is necessary for facial motoneuron survival after axotomy
by: Elizabeth M. Runge, et al.
Published: (2020-04-01)

Expressão das proteínas BCL-2 e BAX em tumores astrocíticos humanos Expression of BCL-2 and BAX proteins in human astrocytic tumors
by: Mário Henrique Girão Faria, et al.
Published: (2006-08-01)

Apoptosis of sensory neurons and satellite cells after sciatic nerve transection in C57BL/6J mice
by: Oliveira A.L.R.
Published: (2001-01-01)

THE EFFECT OF UREA SUPLEMENTATION IN MATURATION MEDIA OF BOVINE OOCYTE IN VITRO TOWARDS EXPRESSION OF BAX, BCL-2 AND BAX/BCL-2 RATIO
by: Dhesy Kartikasari, et al.
Published: (2020-04-01)

Cellular Sources and Neuroprotective Roles of Interleukin-10 in the Facial Motor Nucleus after Axotomy
by: Elizabeth M. Runge, et al.
Published: (2022-10-01)

Evaluation of Bcl2/BAX genes expression ratio as a marker of inflammatory bowel disease
by: Fariba Javadinia, et al.
Published: (2019-06-01)

Changes in the expression of P2X1 and P2X2 purinergic receptors in facial motoneurons after nerve lesions in rodents and correlation with motoneuron degeneration
by: Roman M. Kassa, et al.
Published: (2007-01-01)

Bax, Bcl-2, and Bax/Bcl-2 as prognostic markers in acute myeloid leukemia: are we ready for Bcl-2-directed therapy?
by: Kulsoom B, et al.
Published: (2018-03-01)

Effect of doxorubicin on Bcl2 and Bax expression in Rat heart
by: Mohammadi Gorji S, et al.
Published: (2013-04-01)

Evaluating the effects of hypoxia and taper on expression of Pulmonary Bax and Bcl2 apoptotic proteins
by: Mehdi Yadegari, et al.
Published: (2018-07-01)

Effect of Interval and Continued Exercises with Crocin on Bax/Bcl-2 in Diabetic Obese Rats
by: Ghobad Hassanpour, et al.
Published: (2019-09-01)

NO-Dependent Mechanisms of p53 Expression and Cell Death in Rat’s Dorsal Root Ganglia after Sciatic-Nerve Transection
by: Stanislav Rodkin, et al.
Published: (2022-07-01)

Lipopolysaccharide-induced dental pulp cell apoptosis and the expression of Bax and Bcl-2 in vitro
by: H. Yang, et al.
Published: (2010-11-01)

The role of Bcl-2 protein, Bax protein and there ratio in peripheral blood lymphocytes of asthmatic patients
by: Israa F. Jaffar, et al.
Published: (2008-07-01)

The Expression Pattern of Bcl-2 and Bax in the Tumor and Stromal Cells in Colorectal Carcinoma
by: Nenad Kunac, et al.
Published: (2022-08-01)

Bax/Bcl-2 expression ratio in prediction of response to breast cancer radiotherapy
by: Hosein Azimian, et al.
Published: (2018-03-01)

Expressions of Bcl-2, Bax and Ki67 in the primary pterygium
by: Juan Li, et al.
Published: (2018-05-01)

Expression of Bcl-2 and Bax in Advanced or Metastatic Prostate Carcinoma
by: Abdolazim Sedighi Pashak, et al.
Published: (2012-03-01)

Ciliary extracellular vesicles are distinct from the cytosolic extracellular vesicles
by: Ashraf M. Mohieldin, et al.
Published: (2021-04-01)

The Effect of Continuous Aerobic Training on Bax/Bcl2 Ratio in Pancreatic Tissue Diabetic Rats
by: Mehdi Bostani, et al.
Published: (2021-09-01)

Studying of the Expression of BAX and BCL-2 Genes in Men with Sperm DNA Fragmentation Based on DFI and Comet Assay
by: Hossein Taheri, et al.
Published: (2015-02-01)

Expression of Bcl-2 and Bax genes in peripheral blood lymphocytes of depressed and nondepressed individuals
by: Meisam Amidfar, et al.
Published: (2019-01-01)

Effect of Frequency Aerobic Exercise on Expression of Bcl-2 and Bax Gene in Mice With Myocardial Infarction
by: M Ghahremani, et al.
Published: (2018-02-01)

GDNF Protects against Aluminum-Induced Apoptosis in Rabbits by Upregulating Bcl-2 and Bcl-XL and Inhibiting Mitochondrial Bax Translocation
by: Othman Ghribi, et al.
Published: (2001-10-01)

Ghrelin Administration Increases the Bax/Bcl-2 Gene Expression Ratio in the Heart of Chronic Hypoxic Rats
by: Mohammad Reza Aliparasti, et al.
Published: (2015-06-01)

Expression and Prognostic Significance of Bcl-2 and Bax in The Progression and Clinical Outcome of Transitional Bladder Cell Carcinoma
by: Naser Shakhssalim, et al.
Published: (2013-01-01)

Identification of the Bcl-2 and Bax homologs from Rhipicephalus haemaphysaloides and their function in the degeneration of tick salivary glands
by: Shanming Hu, et al.
Published: (2021-08-01)

The Effect of Dracocephalum kotschyi Alcoholic Extract on the BCL2 and BAX Expression in SKBR3 Cell Line
by: Fatemeh Ketabchi, et al.
Published: (2019-08-01)

Immunohistochemical expression of p53, BCL-2, BAX and VEGFR1 proteins in nephroblastomas A expressão imuno-histoquímica das proteínas p53, BCL-2, BAX e VEGFR1 em nefroblastomas
by: Ana Paula Percicote, et al.
Published: (2013-02-01)

Temporal Stability of Ciliary Beating Post Nasal Brushing, Modulated by Storage Temperature
by: Noemie Bricmont, et al.
Published: (2023-09-01)

Survivin in relation to Bcl-2, Bax and in situ apoptotic cell death in anaplastic thyroid carcinoma
by: Šelemetjev Sonja, et al.
Published: (2011-01-01)