Programmed death-ligand1 is a determinant of recurrence in alveolar echinococcosis
Objectives: Alveolar echinococcosis (AE) recurrence is one of the major stakes in patients undergoing surgery, the main curative treatment. Preliminary data demonstrated an effect of programmed death-ligand1 (PD-L1) inhibitors on AE proliferation in animals. The current study aimed to analyze the pr...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971223000437 |
| _version_ | 1797868277286830080 |
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| author | Gaëtan-Romain Joliat Sebastiao N. Martins-Filho Simon Haefliger Nicolas Demartines Nermin Halkic Ismail Labgaa Christine Sempoux |
| author_facet | Gaëtan-Romain Joliat Sebastiao N. Martins-Filho Simon Haefliger Nicolas Demartines Nermin Halkic Ismail Labgaa Christine Sempoux |
| author_sort | Gaëtan-Romain Joliat |
| collection | DOAJ |
| description | Objectives: Alveolar echinococcosis (AE) recurrence is one of the major stakes in patients undergoing surgery, the main curative treatment. Preliminary data demonstrated an effect of programmed death-ligand1 (PD-L1) inhibitors on AE proliferation in animals. The current study aimed to analyze the prognostic value of PD-L1 expression in tissue samples of patients with AE undergoing surgery. Methods: A cross-sectional study of patients operated for AE between 2002 and 2017 was performed. Patients with recurrence were matched 1: 2 with patients without recurrence. The matching criteria were PNM staging (P = hepatic localization of the parasite, N = extra-hepatic involvement of neighboring organs, and M = absence or presence of metastasis), resection status, preoperative albendazole treatment, and lesion size. PD-L1 immunohistochemistry staining was performed in surgical liver specimens. The expression of PD-L1 was assessed in immune cells. Disease-free survival was calculated using the Kaplan-Meier method. Results: Among 68 consecutive patients, eight patients with recurrence were matched to 16 patients without recurrence. PD-L1 was overexpressed in patients with recurrence (recurrence: PD-L1 <1%: one, PD-L1 ≥1%: seven; no recurrence: PD-L1 <1%: nine, PD-L1 ≥1%: seven, P = 0.040). Moreover, patients with lower PD-L1 expression (<1%) showed better median disease-free survival (120 months, 95% confidence interval 104-135 vs 74, 95% confidence interval 44-104, P = 0.050). Conclusion: These findings highlight the proof of concept of PD-L1 in AE, but further data on its prognostic importance and the role of immune checkpoint blockade as a promising therapeutical strategy are needed. |
| first_indexed | 2024-04-09T23:54:32Z |
| format | Article |
| id | doaj.art-4a1c84fa2da74412b4c3910a72701f6b |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-04-09T23:54:32Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-4a1c84fa2da74412b4c3910a72701f6b2023-03-17T04:32:48ZengElsevierInternational Journal of Infectious Diseases1201-97122023-04-01129285288Programmed death-ligand1 is a determinant of recurrence in alveolar echinococcosisGaëtan-Romain Joliat0Sebastiao N. Martins-Filho1Simon Haefliger2Nicolas Demartines3Nermin Halkic4Ismail Labgaa5Christine Sempoux6Department of Visceral Surgery, Lausanne University Hospital CHUV, University of Lausanne (UNIL), Lausanne, SwitzerlandDepartment of Laboratory, Medicine and Pathology, University of Alberta, Edmonton, CanadaInstitute of Pathology, Lausanne University Hospital CHUV, University of Lausanne (UNIL), Lausanne, SwitzerlandDepartment of Visceral Surgery, Lausanne University Hospital CHUV, University of Lausanne (UNIL), Lausanne, Switzerland; Corresponding author: (N. Demartines); Tel: +41 21 314 24 00; Fax: +41 21 314 23 11.Department of Visceral Surgery, Lausanne University Hospital CHUV, University of Lausanne (UNIL), Lausanne, SwitzerlandDepartment of Visceral Surgery, Lausanne University Hospital CHUV, University of Lausanne (UNIL), Lausanne, SwitzerlandInstitute of Pathology, Lausanne University Hospital CHUV, University of Lausanne (UNIL), Lausanne, SwitzerlandObjectives: Alveolar echinococcosis (AE) recurrence is one of the major stakes in patients undergoing surgery, the main curative treatment. Preliminary data demonstrated an effect of programmed death-ligand1 (PD-L1) inhibitors on AE proliferation in animals. The current study aimed to analyze the prognostic value of PD-L1 expression in tissue samples of patients with AE undergoing surgery. Methods: A cross-sectional study of patients operated for AE between 2002 and 2017 was performed. Patients with recurrence were matched 1: 2 with patients without recurrence. The matching criteria were PNM staging (P = hepatic localization of the parasite, N = extra-hepatic involvement of neighboring organs, and M = absence or presence of metastasis), resection status, preoperative albendazole treatment, and lesion size. PD-L1 immunohistochemistry staining was performed in surgical liver specimens. The expression of PD-L1 was assessed in immune cells. Disease-free survival was calculated using the Kaplan-Meier method. Results: Among 68 consecutive patients, eight patients with recurrence were matched to 16 patients without recurrence. PD-L1 was overexpressed in patients with recurrence (recurrence: PD-L1 <1%: one, PD-L1 ≥1%: seven; no recurrence: PD-L1 <1%: nine, PD-L1 ≥1%: seven, P = 0.040). Moreover, patients with lower PD-L1 expression (<1%) showed better median disease-free survival (120 months, 95% confidence interval 104-135 vs 74, 95% confidence interval 44-104, P = 0.050). Conclusion: These findings highlight the proof of concept of PD-L1 in AE, but further data on its prognostic importance and the role of immune checkpoint blockade as a promising therapeutical strategy are needed.http://www.sciencedirect.com/science/article/pii/S1201971223000437ZoonosisHepatectomyParasiteImmunologyCheckpoint blockade |
| spellingShingle | Gaëtan-Romain Joliat Sebastiao N. Martins-Filho Simon Haefliger Nicolas Demartines Nermin Halkic Ismail Labgaa Christine Sempoux Programmed death-ligand1 is a determinant of recurrence in alveolar echinococcosis International Journal of Infectious Diseases Zoonosis Hepatectomy Parasite Immunology Checkpoint blockade |
| title | Programmed death-ligand1 is a determinant of recurrence in alveolar echinococcosis |
| title_full | Programmed death-ligand1 is a determinant of recurrence in alveolar echinococcosis |
| title_fullStr | Programmed death-ligand1 is a determinant of recurrence in alveolar echinococcosis |
| title_full_unstemmed | Programmed death-ligand1 is a determinant of recurrence in alveolar echinococcosis |
| title_short | Programmed death-ligand1 is a determinant of recurrence in alveolar echinococcosis |
| title_sort | programmed death ligand1 is a determinant of recurrence in alveolar echinococcosis |
| topic | Zoonosis Hepatectomy Parasite Immunology Checkpoint blockade |
| url | http://www.sciencedirect.com/science/article/pii/S1201971223000437 |
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