Sulfonamide-Derived Dithiocarbamate Gold(I) Complexes Induce the Apoptosis of Colon Cancer Cells by the Activation of Caspase 3 and Redox Imbalance

Sulfonamide-Derived Dithiocarbamate Gold(I) Complexes Induce the Apoptosis of Colon Cancer Cells by the Activation of Caspase 3 and Redox Imbalance

Two new families of dithiocarbamate gold(I) complexes derived from benzenesulfonamide with phosphine or carbene as ancillary ligands have been synthesized and characterized. In the screening of their in vitro activity on human colon carcinoma cells (Caco-2), we found that the more lipophilic complex...

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Bibliographic Details
Main Authors:	Javier Quero, José Carlos Royo, Beatrice Fodor, María Concepción Gimeno, Jesús Osada, María Jesús Rodríguez-Yoldi, Elena Cerrada
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	Biomedicines
Subjects:	dithiocarbamate sulfonamide thioredoxin reductase gold(I) colon cancer carbonic anhydrase
Online Access:	https://www.mdpi.com/2227-9059/10/6/1437

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