Prognostic factors and survival study in high-grade glioma in a hospital in Lima, Peru
Introduction: Gliomas are primary tumors of the central nervous system. They are classifiedfrom grade I-IV, with high grade III and IV being the most frequent and with poor prognosis. Objective: To determine the prognostic factors of survival in patients with high-gradegliomas in a hospital in Lima,...
| Autores principales: | , |
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| Formato: | Artículo |
| Lenguaje: | Spanish |
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Universidad Ricardo Palma
2020-07-01
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| Colección: | Revista de la Facultad de Medicina Humana |
| Materias: | |
| Acceso en línea: | http://revistas.urp.edu.pe/index.php/RFMH/article/view/3170 |
| _version_ | 1829471047174324224 |
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| author | Paul Méndez-Aguilar Victor Juan Vera-Ponce |
| author_facet | Paul Méndez-Aguilar Victor Juan Vera-Ponce |
| author_sort | Paul Méndez-Aguilar |
| collection | DOAJ |
| description | Introduction: Gliomas are primary tumors of the central nervous system. They are classifiedfrom grade I-IV, with high grade III and IV being the most frequent and with poor prognosis. Objective: To determine the prognostic factors of survival in patients with high-gradegliomas in a hospital in Lima, Peru. Methods: The medical records with high-grade gliomafrom 2010-2014 were retrospectively reviewed, ten variables were analyzed with Kaplan-Meier and Log Rank survival graphs and the Cox regression model. Results: Out of a total of278 patients with high-grade gliomas, 136 were men and 142 women. The analysis of Progression-Free Survival (SLP) had a range of 5.6-80.3 (median 22.7) and the analysis ofoverall survival (PS) had a range of 4-83.2 (median 26, 2 months. The overall survival for theIV grade tumor was 15.7 months (95% CI 14.2-17.1); the III degree was 38.4 months (95%CI 35.8-40.9). The grade (PS: HR 15; SLP: HR 25.1); surgical treatment (PS: HR 0.6; SLP:HR 0.49), age (PS: HR 1.47; SLP: HR 1.7), adjuvant treatment (PS: HR 0.6; SLP: HR 0 , 58)and karnofsky (PS: HR 0.7) were correlated; while the Karnofsky for SLP does not (P =0.146). Conclusion: age, functional status, surgical treatment, adjuvant treatment, and tumorgrade are prognostic factors for PS. In contrast, for SLP the prognostic factors were age,surgical treatment, adjuvant treatment, and tumor grade. |
| first_indexed | 2024-12-14T01:53:21Z |
| format | Article |
| id | doaj.art-4a1e7c2fd48e4b8b98bb5cd20d68d0c9 |
| institution | Directory Open Access Journal |
| issn | 1814-5469 2308-0531 |
| language | Spanish |
| last_indexed | 2024-12-14T01:53:21Z |
| publishDate | 2020-07-01 |
| publisher | Universidad Ricardo Palma |
| record_format | Article |
| series | Revista de la Facultad de Medicina Humana |
| spelling | doaj.art-4a1e7c2fd48e4b8b98bb5cd20d68d0c92022-12-21T23:21:18ZspaUniversidad Ricardo PalmaRevista de la Facultad de Medicina Humana1814-54692308-05312020-07-0120345246310.25176/RFMH.v20i3.3170Prognostic factors and survival study in high-grade glioma in a hospital in Lima, PeruPaul Méndez-Aguilarhttps://orcid.org/0000-0003-2140-4138Victor Juan Vera-Poncehttps://orcid.org/0000-0003-4075-9049Introduction: Gliomas are primary tumors of the central nervous system. They are classifiedfrom grade I-IV, with high grade III and IV being the most frequent and with poor prognosis. Objective: To determine the prognostic factors of survival in patients with high-gradegliomas in a hospital in Lima, Peru. Methods: The medical records with high-grade gliomafrom 2010-2014 were retrospectively reviewed, ten variables were analyzed with Kaplan-Meier and Log Rank survival graphs and the Cox regression model. Results: Out of a total of278 patients with high-grade gliomas, 136 were men and 142 women. The analysis of Progression-Free Survival (SLP) had a range of 5.6-80.3 (median 22.7) and the analysis ofoverall survival (PS) had a range of 4-83.2 (median 26, 2 months. The overall survival for theIV grade tumor was 15.7 months (95% CI 14.2-17.1); the III degree was 38.4 months (95%CI 35.8-40.9). The grade (PS: HR 15; SLP: HR 25.1); surgical treatment (PS: HR 0.6; SLP:HR 0.49), age (PS: HR 1.47; SLP: HR 1.7), adjuvant treatment (PS: HR 0.6; SLP: HR 0 , 58)and karnofsky (PS: HR 0.7) were correlated; while the Karnofsky for SLP does not (P =0.146). Conclusion: age, functional status, surgical treatment, adjuvant treatment, and tumorgrade are prognostic factors for PS. In contrast, for SLP the prognostic factors were age,surgical treatment, adjuvant treatment, and tumor grade.http://revistas.urp.edu.pe/index.php/RFMH/article/view/3170survivalprogression-free survivalkarnofsky performance statusglioma |
| spellingShingle | Paul Méndez-Aguilar Victor Juan Vera-Ponce Prognostic factors and survival study in high-grade glioma in a hospital in Lima, Peru Revista de la Facultad de Medicina Humana survival progression-free survival karnofsky performance status glioma |
| title | Prognostic factors and survival study in high-grade glioma in a hospital in Lima, Peru |
| title_full | Prognostic factors and survival study in high-grade glioma in a hospital in Lima, Peru |
| title_fullStr | Prognostic factors and survival study in high-grade glioma in a hospital in Lima, Peru |
| title_full_unstemmed | Prognostic factors and survival study in high-grade glioma in a hospital in Lima, Peru |
| title_short | Prognostic factors and survival study in high-grade glioma in a hospital in Lima, Peru |
| title_sort | prognostic factors and survival study in high grade glioma in a hospital in lima peru |
| topic | survival progression-free survival karnofsky performance status glioma |
| url | http://revistas.urp.edu.pe/index.php/RFMH/article/view/3170 |
| work_keys_str_mv | AT paulmendezaguilar prognosticfactorsandsurvivalstudyinhighgradegliomainahospitalinlimaperu AT victorjuanveraponce prognosticfactorsandsurvivalstudyinhighgradegliomainahospitalinlimaperu |