Characteristics Associated with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients, Texas, USA, 2013–2015
Interferon-γ release assays (IGRAs) are the preferred diagnostic test for tuberculosis (TB) infection in at-risk populations in developed countries. However, IGRAs have high false-negative rates in patients with TB disease. Population-based studies assessing the factors associated with negative IGRA...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
2018-03-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/24/3/17-1633_article |
| _version_ | 1818110977779957760 |
|---|---|
| author | Duc T. Nguyen Larry D. Teeter Julie Graves Edward A. Graviss |
| author_facet | Duc T. Nguyen Larry D. Teeter Julie Graves Edward A. Graviss |
| author_sort | Duc T. Nguyen |
| collection | DOAJ |
| description | Interferon-γ release assays (IGRAs) are the preferred diagnostic test for tuberculosis (TB) infection in at-risk populations in developed countries. However, IGRAs have high false-negative rates in patients with TB disease. Population-based studies assessing the factors associated with negative IGRA results in TB patients have not been performed. Using statewide TB surveillance data of culture-confirmed TB patients in Texas, USA, during 2013–2015, we describe the patient characteristics and treatment outcomes associated with false-negative IGRA results. Among 2,854 TB patients, 1,527 (53.5%) had an IGRA result; 97.4% (1,487/1,527) of those had a positive (87.7%) or negative (12.3%) result. Older age, HIV co-infection, non-Hispanic white race/ethnicity, and being tested with T-SPOT.TB were associated with negative IGRA results. TB patients with negative IGRA results had a higher mortality, potentially due to delayed treatment. Healthcare providers should consider these risk factors when making decisions for patients with suspected TB and negative IGRA results and potentially provide treatment. |
| first_indexed | 2024-12-11T02:55:43Z |
| format | Article |
| id | doaj.art-4a1f51e7133b4316968824742259abd2 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-11T02:55:43Z |
| publishDate | 2018-03-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-4a1f51e7133b4316968824742259abd22022-12-22T01:23:10ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592018-03-0124353454010.3201/eid2403.171633Characteristics Associated with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients, Texas, USA, 2013–2015Duc T. NguyenLarry D. TeeterJulie GravesEdward A. GravissInterferon-γ release assays (IGRAs) are the preferred diagnostic test for tuberculosis (TB) infection in at-risk populations in developed countries. However, IGRAs have high false-negative rates in patients with TB disease. Population-based studies assessing the factors associated with negative IGRA results in TB patients have not been performed. Using statewide TB surveillance data of culture-confirmed TB patients in Texas, USA, during 2013–2015, we describe the patient characteristics and treatment outcomes associated with false-negative IGRA results. Among 2,854 TB patients, 1,527 (53.5%) had an IGRA result; 97.4% (1,487/1,527) of those had a positive (87.7%) or negative (12.3%) result. Older age, HIV co-infection, non-Hispanic white race/ethnicity, and being tested with T-SPOT.TB were associated with negative IGRA results. TB patients with negative IGRA results had a higher mortality, potentially due to delayed treatment. Healthcare providers should consider these risk factors when making decisions for patients with suspected TB and negative IGRA results and potentially provide treatment.https://wwwnc.cdc.gov/eid/article/24/3/17-1633_articletuberculosisIGRAQuantiFERONT-SPOTT-SPOT.TBculture |
| spellingShingle | Duc T. Nguyen Larry D. Teeter Julie Graves Edward A. Graviss Characteristics Associated with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients, Texas, USA, 2013–2015 Emerging Infectious Diseases tuberculosis IGRA QuantiFERON T-SPOT T-SPOT.TB culture |
| title | Characteristics Associated with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients, Texas, USA, 2013–2015 |
| title_full | Characteristics Associated with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients, Texas, USA, 2013–2015 |
| title_fullStr | Characteristics Associated with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients, Texas, USA, 2013–2015 |
| title_full_unstemmed | Characteristics Associated with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients, Texas, USA, 2013–2015 |
| title_short | Characteristics Associated with Negative Interferon-γ Release Assay Results in Culture-Confirmed Tuberculosis Patients, Texas, USA, 2013–2015 |
| title_sort | characteristics associated with negative interferon γ release assay results in culture confirmed tuberculosis patients texas usa 2013 2015 |
| topic | tuberculosis IGRA QuantiFERON T-SPOT T-SPOT.TB culture |
| url | https://wwwnc.cdc.gov/eid/article/24/3/17-1633_article |
| work_keys_str_mv | AT ductnguyen characteristicsassociatedwithnegativeinterferongreleaseassayresultsincultureconfirmedtuberculosispatientstexasusa20132015 AT larrydteeter characteristicsassociatedwithnegativeinterferongreleaseassayresultsincultureconfirmedtuberculosispatientstexasusa20132015 AT juliegraves characteristicsassociatedwithnegativeinterferongreleaseassayresultsincultureconfirmedtuberculosispatientstexasusa20132015 AT edwardagraviss characteristicsassociatedwithnegativeinterferongreleaseassayresultsincultureconfirmedtuberculosispatientstexasusa20132015 |