Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review
Objectives: To review the current understanding of the biomarkers and enzymes associated with different forms peri-implant diseases and how their level changes influence the pathogenesis of the inflammatory diseases around dental implants. Material and Methods: An electronic search in two differe...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Stilus Optimus
2016-09-01
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| Series: | eJournal of Oral Maxillofacial Research |
| Subjects: | |
| Online Access: | http://www.ejomr.org/JOMR/archives/2016/3/e9/v7n3e9ht.htm |
| _version_ | 1818524677836898304 |
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| author | Erhan Dursun Tolga F. Tözüm |
| author_facet | Erhan Dursun Tolga F. Tözüm |
| author_sort | Erhan Dursun |
| collection | DOAJ |
| description | Objectives: To review the current understanding of the biomarkers and enzymes associated with different forms peri-implant diseases and how their level changes influence the pathogenesis of the inflammatory diseases around dental implants.
Material and Methods: An electronic search in two different databases was performed including MEDLINE (PubMed) and EMBASE between 1996 to 2016. Human studies analyse peri-implant crevicular fluid (PICF) biomarker and enzyme levels of implants having peri-implant mucositis and peri-implantitis published in English language, were evaluated. A systematic review was performed to assess which biomarkers and enzymes in PICF were used to identify the inflammatory conditions around dental implants.
Results: Fifty-one articles were identified of which 41 were further evaluated and included in the analysis. Due to significant heterogeneity between included studies, a meta-analysis could not be performed. Instead, a systematic descriptive review was performed.
Conclusions: Biomarkers and enzymes in peri-implant crevicular fluid have shown promising results in differentiating from peri-implant disease condition to health. However, due to inconsistent results and acquiring much evidence from cross-sectional studies, additional evidence supported by randomized-controlled trials is needed to validate the links reported. |
| first_indexed | 2024-12-11T06:00:06Z |
| format | Article |
| id | doaj.art-4a1f79598154488d91ba6a552478ba35 |
| institution | Directory Open Access Journal |
| issn | 2029-283X |
| language | English |
| last_indexed | 2024-12-11T06:00:06Z |
| publishDate | 2016-09-01 |
| publisher | Stilus Optimus |
| record_format | Article |
| series | eJournal of Oral Maxillofacial Research |
| spelling | doaj.art-4a1f79598154488d91ba6a552478ba352022-12-22T01:18:30ZengStilus OptimuseJournal of Oral Maxillofacial Research2029-283X2016-09-0173e910.5037/jomr.2016.7309Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic ReviewErhan DursunTolga F. TözümObjectives: To review the current understanding of the biomarkers and enzymes associated with different forms peri-implant diseases and how their level changes influence the pathogenesis of the inflammatory diseases around dental implants. Material and Methods: An electronic search in two different databases was performed including MEDLINE (PubMed) and EMBASE between 1996 to 2016. Human studies analyse peri-implant crevicular fluid (PICF) biomarker and enzyme levels of implants having peri-implant mucositis and peri-implantitis published in English language, were evaluated. A systematic review was performed to assess which biomarkers and enzymes in PICF were used to identify the inflammatory conditions around dental implants. Results: Fifty-one articles were identified of which 41 were further evaluated and included in the analysis. Due to significant heterogeneity between included studies, a meta-analysis could not be performed. Instead, a systematic descriptive review was performed. Conclusions: Biomarkers and enzymes in peri-implant crevicular fluid have shown promising results in differentiating from peri-implant disease condition to health. However, due to inconsistent results and acquiring much evidence from cross-sectional studies, additional evidence supported by randomized-controlled trials is needed to validate the links reported.http://www.ejomr.org/JOMR/archives/2016/3/e9/v7n3e9ht.htmbiomarkersdental implantsdiagnosisenzymesinflammation |
| spellingShingle | Erhan Dursun Tolga F. Tözüm Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review eJournal of Oral Maxillofacial Research biomarkers dental implants diagnosis enzymes inflammation |
| title | Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review |
| title_full | Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review |
| title_fullStr | Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review |
| title_full_unstemmed | Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review |
| title_short | Peri-Implant Crevicular Fluid Analysis, Enzymes and Biomarkers: a Systemetic Review |
| title_sort | peri implant crevicular fluid analysis enzymes and biomarkers a systemetic review |
| topic | biomarkers dental implants diagnosis enzymes inflammation |
| url | http://www.ejomr.org/JOMR/archives/2016/3/e9/v7n3e9ht.htm |
| work_keys_str_mv | AT erhandursun periimplantcrevicularfluidanalysisenzymesandbiomarkersasystemeticreview AT tolgaftozum periimplantcrevicularfluidanalysisenzymesandbiomarkersasystemeticreview |