A Comprehensive Review on Anti-Inflammatory Response of Flavonoids in Experimentally-Induced Epileptic Seizures
Flavonoids, a group of natural compounds with phenolic structure, are becoming popular as alternative medicines obtained from plants. These compounds are reported to have various pharmacological properties, including attenuation of inflammatory responses in multiple health issues. Epilepsy is a diso...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-01-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/13/1/102 |
| _version_ | 1797445194093690880 |
|---|---|
| author | Shyam Sunder Rabidas Chandra Prakash Jyoti Tyagi Jyoti Suryavanshi Pavan Kumar Jaydeep Bhattacharya Deepak Sharma |
| author_facet | Shyam Sunder Rabidas Chandra Prakash Jyoti Tyagi Jyoti Suryavanshi Pavan Kumar Jaydeep Bhattacharya Deepak Sharma |
| author_sort | Shyam Sunder Rabidas |
| collection | DOAJ |
| description | Flavonoids, a group of natural compounds with phenolic structure, are becoming popular as alternative medicines obtained from plants. These compounds are reported to have various pharmacological properties, including attenuation of inflammatory responses in multiple health issues. Epilepsy is a disorder of the central nervous system implicated with the activation of the inflammatory cascade in the brain. The aim of the present study was to summarize the role of various neuroinflammatory mediators in the onset and progression of epilepsy, and, thereafter, to discuss the flavonoids and their classes, including their biological properties. Further, we highlighted the modulation of anti-inflammatory responses achieved by these substances in different forms of epilepsy, as evident from preclinical studies executed on multiple epilepsy models. Overall, the review summarizes the available evidence of the anti-inflammatory potential of various flavonoids in epilepsy. |
| first_indexed | 2024-03-09T13:23:13Z |
| format | Article |
| id | doaj.art-4a1ff10001194ba89cbd3b03845e20cf |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T13:23:13Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-4a1ff10001194ba89cbd3b03845e20cf2023-11-30T21:27:40ZengMDPI AGBrain Sciences2076-34252023-01-0113110210.3390/brainsci13010102A Comprehensive Review on Anti-Inflammatory Response of Flavonoids in Experimentally-Induced Epileptic SeizuresShyam Sunder Rabidas0Chandra Prakash1Jyoti Tyagi2Jyoti Suryavanshi3Pavan Kumar4Jaydeep Bhattacharya5Deepak Sharma6Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, IndiaNeurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, IndiaNeurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, IndiaNeurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, IndiaDepartment of Anatomy and Cell Biology, College of Medicine, The University of Illinois at Chicago, Chicago, IL 60607, USANanobiotechnology Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi 110067, IndiaNeurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, IndiaFlavonoids, a group of natural compounds with phenolic structure, are becoming popular as alternative medicines obtained from plants. These compounds are reported to have various pharmacological properties, including attenuation of inflammatory responses in multiple health issues. Epilepsy is a disorder of the central nervous system implicated with the activation of the inflammatory cascade in the brain. The aim of the present study was to summarize the role of various neuroinflammatory mediators in the onset and progression of epilepsy, and, thereafter, to discuss the flavonoids and their classes, including their biological properties. Further, we highlighted the modulation of anti-inflammatory responses achieved by these substances in different forms of epilepsy, as evident from preclinical studies executed on multiple epilepsy models. Overall, the review summarizes the available evidence of the anti-inflammatory potential of various flavonoids in epilepsy.https://www.mdpi.com/2076-3425/13/1/102epilepsyseizuresinflammationanti-inflammatory responseflavonoids |
| spellingShingle | Shyam Sunder Rabidas Chandra Prakash Jyoti Tyagi Jyoti Suryavanshi Pavan Kumar Jaydeep Bhattacharya Deepak Sharma A Comprehensive Review on Anti-Inflammatory Response of Flavonoids in Experimentally-Induced Epileptic Seizures Brain Sciences epilepsy seizures inflammation anti-inflammatory response flavonoids |
| title | A Comprehensive Review on Anti-Inflammatory Response of Flavonoids in Experimentally-Induced Epileptic Seizures |
| title_full | A Comprehensive Review on Anti-Inflammatory Response of Flavonoids in Experimentally-Induced Epileptic Seizures |
| title_fullStr | A Comprehensive Review on Anti-Inflammatory Response of Flavonoids in Experimentally-Induced Epileptic Seizures |
| title_full_unstemmed | A Comprehensive Review on Anti-Inflammatory Response of Flavonoids in Experimentally-Induced Epileptic Seizures |
| title_short | A Comprehensive Review on Anti-Inflammatory Response of Flavonoids in Experimentally-Induced Epileptic Seizures |
| title_sort | comprehensive review on anti inflammatory response of flavonoids in experimentally induced epileptic seizures |
| topic | epilepsy seizures inflammation anti-inflammatory response flavonoids |
| url | https://www.mdpi.com/2076-3425/13/1/102 |
| work_keys_str_mv | AT shyamsunderrabidas acomprehensivereviewonantiinflammatoryresponseofflavonoidsinexperimentallyinducedepilepticseizures AT chandraprakash acomprehensivereviewonantiinflammatoryresponseofflavonoidsinexperimentallyinducedepilepticseizures AT jyotityagi acomprehensivereviewonantiinflammatoryresponseofflavonoidsinexperimentallyinducedepilepticseizures AT jyotisuryavanshi acomprehensivereviewonantiinflammatoryresponseofflavonoidsinexperimentallyinducedepilepticseizures AT pavankumar acomprehensivereviewonantiinflammatoryresponseofflavonoidsinexperimentallyinducedepilepticseizures AT jaydeepbhattacharya acomprehensivereviewonantiinflammatoryresponseofflavonoidsinexperimentallyinducedepilepticseizures AT deepaksharma acomprehensivereviewonantiinflammatoryresponseofflavonoidsinexperimentallyinducedepilepticseizures AT shyamsunderrabidas comprehensivereviewonantiinflammatoryresponseofflavonoidsinexperimentallyinducedepilepticseizures AT chandraprakash comprehensivereviewonantiinflammatoryresponseofflavonoidsinexperimentallyinducedepilepticseizures AT jyotityagi comprehensivereviewonantiinflammatoryresponseofflavonoidsinexperimentallyinducedepilepticseizures AT jyotisuryavanshi comprehensivereviewonantiinflammatoryresponseofflavonoidsinexperimentallyinducedepilepticseizures AT pavankumar comprehensivereviewonantiinflammatoryresponseofflavonoidsinexperimentallyinducedepilepticseizures AT jaydeepbhattacharya comprehensivereviewonantiinflammatoryresponseofflavonoidsinexperimentallyinducedepilepticseizures AT deepaksharma comprehensivereviewonantiinflammatoryresponseofflavonoidsinexperimentallyinducedepilepticseizures |