TNIK inhibition abrogates colorectal cancer stemness
TRAF2 and NCK-interacting protein kinase (TNIK) is a key regulatory component of the TCF4 and β-catenin transcriptional complex. In this study, the authors identify a TNIK inhibitor that blocks Wnt signalling and Wnt-driven colorectal tumorigenesis in mice.
Bibliographic Details
| Main Authors: |
Mari Masuda,
Yuko Uno,
Naomi Ohbayashi,
Hirokazu Ohata,
Ayako Mimata,
Mutsuko Kukimoto-Niino,
Hideki Moriyama,
Shigeki Kashimoto,
Tomoko Inoue,
Naoko Goto,
Koji Okamoto,
Mikako Shirouzu,
Masaaki Sawa,
Tesshi Yamada |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2016-08-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms12586
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