TNIK inhibition abrogates colorectal cancer stemness
TRAF2 and NCK-interacting protein kinase (TNIK) is a key regulatory component of the TCF4 and β-catenin transcriptional complex. In this study, the authors identify a TNIK inhibitor that blocks Wnt signalling and Wnt-driven colorectal tumorigenesis in mice.
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12586 |
| _version_ | 1828958815814418432 |
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| author | Mari Masuda Yuko Uno Naomi Ohbayashi Hirokazu Ohata Ayako Mimata Mutsuko Kukimoto-Niino Hideki Moriyama Shigeki Kashimoto Tomoko Inoue Naoko Goto Koji Okamoto Mikako Shirouzu Masaaki Sawa Tesshi Yamada |
| author_facet | Mari Masuda Yuko Uno Naomi Ohbayashi Hirokazu Ohata Ayako Mimata Mutsuko Kukimoto-Niino Hideki Moriyama Shigeki Kashimoto Tomoko Inoue Naoko Goto Koji Okamoto Mikako Shirouzu Masaaki Sawa Tesshi Yamada |
| author_sort | Mari Masuda |
| collection | DOAJ |
| description | TRAF2 and NCK-interacting protein kinase (TNIK) is a key regulatory component of the TCF4 and β-catenin transcriptional complex. In this study, the authors identify a TNIK inhibitor that blocks Wnt signalling and Wnt-driven colorectal tumorigenesis in mice. |
| first_indexed | 2024-12-14T08:55:28Z |
| format | Article |
| id | doaj.art-4a216298e0fc4be591ff7743d3af46e1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T08:55:28Z |
| publishDate | 2016-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4a216298e0fc4be591ff7743d3af46e12022-12-21T23:08:56ZengNature PortfolioNature Communications2041-17232016-08-017111410.1038/ncomms12586TNIK inhibition abrogates colorectal cancer stemnessMari Masuda0Yuko Uno1Naomi Ohbayashi2Hirokazu Ohata3Ayako Mimata4Mutsuko Kukimoto-Niino5Hideki Moriyama6Shigeki Kashimoto7Tomoko Inoue8Naoko Goto9Koji Okamoto10Mikako Shirouzu11Masaaki Sawa12Tesshi Yamada13Division of Chemotherapy and Clinical Research, National Cancer Center Research InstituteCarna Biosciences, Inc.Division of Structural and Synthetic Biology, RIKEN Center for Life Science TechnologiesDivision of Cancer Differentiation, National Cancer Center Research InstituteDivision of Chemotherapy and Clinical Research, National Cancer Center Research InstituteDivision of Structural and Synthetic Biology, RIKEN Center for Life Science TechnologiesCarna Biosciences, Inc.Carna Biosciences, Inc.Carna Biosciences, Inc.Division of Chemotherapy and Clinical Research, National Cancer Center Research InstituteDivision of Cancer Differentiation, National Cancer Center Research InstituteDivision of Structural and Synthetic Biology, RIKEN Center for Life Science TechnologiesCarna Biosciences, Inc.Division of Chemotherapy and Clinical Research, National Cancer Center Research InstituteTRAF2 and NCK-interacting protein kinase (TNIK) is a key regulatory component of the TCF4 and β-catenin transcriptional complex. In this study, the authors identify a TNIK inhibitor that blocks Wnt signalling and Wnt-driven colorectal tumorigenesis in mice.https://doi.org/10.1038/ncomms12586 |
| spellingShingle | Mari Masuda Yuko Uno Naomi Ohbayashi Hirokazu Ohata Ayako Mimata Mutsuko Kukimoto-Niino Hideki Moriyama Shigeki Kashimoto Tomoko Inoue Naoko Goto Koji Okamoto Mikako Shirouzu Masaaki Sawa Tesshi Yamada TNIK inhibition abrogates colorectal cancer stemness Nature Communications |
| title | TNIK inhibition abrogates colorectal cancer stemness |
| title_full | TNIK inhibition abrogates colorectal cancer stemness |
| title_fullStr | TNIK inhibition abrogates colorectal cancer stemness |
| title_full_unstemmed | TNIK inhibition abrogates colorectal cancer stemness |
| title_short | TNIK inhibition abrogates colorectal cancer stemness |
| title_sort | tnik inhibition abrogates colorectal cancer stemness |
| url | https://doi.org/10.1038/ncomms12586 |
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