Resveratrol suppresses neuroinflammation to alleviate mechanical allodynia by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway in a rat model of spinal cord injury

Resveratrol suppresses neuroinflammation to alleviate mechanical allodynia by inhibiting Janus kinase 2/signal transducer and activator of transcription 3 signaling pathway in a rat model of spinal cord injury

BackgroundNeuropathic pain (NP) is one of intractable complications of spinal cord injury (SCI) and lacks effective treatment. Resveratrol (Res) has been shown to possess potent anti-inflammatory and anti-nociceptive effects. In this study, we investigated the analgesic effect of Res and its underly...

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Bibliographic Details
Main Authors: Jie Han, Zhen Hua, Wen-jie Yang, Shu Wang, Fang Yan, Jun-nan Wang, Tao Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neuropathic pain
spinal cord injury
resveratrol
Janus kinase 2/signal transducer and activator of transcription 3
neuroinflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1116679/full

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