The Effects of Periodontal Treatment on Rheumatoid Arthritis and of Anti-Rheumatic Drugs on Periodontitis: A Systematic Review
Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases that widely spread and share the same patterns of pro-inflammatory cytokines. This systematic review aims to evaluate the effects of non-surgical periodontal treatment (NSPT) on RA and, conversely, the impact of disease-mo...
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/24/17228 |
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| author | Francesco Inchingolo Angelo Michele Inchingolo Pasquale Avantario Vito Settanni Maria Celeste Fatone Fabio Piras Daniela Di Venere Alessio Danilo Inchingolo Andrea Palermo Gianna Dipalma |
| author_facet | Francesco Inchingolo Angelo Michele Inchingolo Pasquale Avantario Vito Settanni Maria Celeste Fatone Fabio Piras Daniela Di Venere Alessio Danilo Inchingolo Andrea Palermo Gianna Dipalma |
| author_sort | Francesco Inchingolo |
| collection | DOAJ |
| description | Rheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases that widely spread and share the same patterns of pro-inflammatory cytokines. This systematic review aims to evaluate the effects of non-surgical periodontal treatment (NSPT) on RA and, conversely, the impact of disease-modifying anti-rheumatic drugs (DMARDs) on periodontitis. PubMed, Embase, and Web of Science were searched using the MESH terms “periodontitis” and “rheumatoid arthritis” from January 2012 to September 2023. A total of 49 articles was included in the final analysis, 10 of which were randomized controlled trials. A total of 31 records concerns the effect of NSPT on parameters of RA disease activity, including a 28-joint disease activity score, anti-citrullinated protein antibodies, rheumatoid factor, C reactive protein, erythrocyte sedimentation rate, pro-inflammatory cytokines and acute phase proteins in serum, saliva, gingival crevicular fluid, and synovial fluid. A total of 18 articles investigated the effect of DMARDs on periodontal indexes and on specific cytokine levels. A quality assessment and risk-of-bias of the studies were also performed. Despite some conflicting results, there is evidence that RA patients and periodontitis patients benefit from NSPT and DMARDs, respectively. The limitations of the studies examined are the small samples and the short follow-up (usually 6 months). Further research is mandatory to evaluate if screening and treatment of periodontitis should be performed systematically in RA patients, and if the administration of DMARDs is useful in reducing the production of cytokines in the periodontium. |
| first_indexed | 2024-03-08T20:41:41Z |
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| publishDate | 2023-12-01 |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4a26d1c73e724260b8d3f0df23c000a32023-12-22T14:13:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0124241722810.3390/ijms242417228The Effects of Periodontal Treatment on Rheumatoid Arthritis and of Anti-Rheumatic Drugs on Periodontitis: A Systematic ReviewFrancesco Inchingolo0Angelo Michele Inchingolo1Pasquale Avantario2Vito Settanni3Maria Celeste Fatone4Fabio Piras5Daniela Di Venere6Alessio Danilo Inchingolo7Andrea Palermo8Gianna Dipalma9Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyPTA Trani-ASL BT, Viale Padre Pio, 76125 Trani, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyCollege of Medicine and Dentistry, Birmingham B4 6BN, UKDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyRheumatoid arthritis (RA) and periodontitis are chronic inflammatory diseases that widely spread and share the same patterns of pro-inflammatory cytokines. This systematic review aims to evaluate the effects of non-surgical periodontal treatment (NSPT) on RA and, conversely, the impact of disease-modifying anti-rheumatic drugs (DMARDs) on periodontitis. PubMed, Embase, and Web of Science were searched using the MESH terms “periodontitis” and “rheumatoid arthritis” from January 2012 to September 2023. A total of 49 articles was included in the final analysis, 10 of which were randomized controlled trials. A total of 31 records concerns the effect of NSPT on parameters of RA disease activity, including a 28-joint disease activity score, anti-citrullinated protein antibodies, rheumatoid factor, C reactive protein, erythrocyte sedimentation rate, pro-inflammatory cytokines and acute phase proteins in serum, saliva, gingival crevicular fluid, and synovial fluid. A total of 18 articles investigated the effect of DMARDs on periodontal indexes and on specific cytokine levels. A quality assessment and risk-of-bias of the studies were also performed. Despite some conflicting results, there is evidence that RA patients and periodontitis patients benefit from NSPT and DMARDs, respectively. The limitations of the studies examined are the small samples and the short follow-up (usually 6 months). Further research is mandatory to evaluate if screening and treatment of periodontitis should be performed systematically in RA patients, and if the administration of DMARDs is useful in reducing the production of cytokines in the periodontium.https://www.mdpi.com/1422-0067/24/24/17228cytokinesdisease-modifying anti-rheumatic drugsnon-surgical periodontal treatmentoral microbiotaperiodontitisrheumatoid arthritis |
| spellingShingle | Francesco Inchingolo Angelo Michele Inchingolo Pasquale Avantario Vito Settanni Maria Celeste Fatone Fabio Piras Daniela Di Venere Alessio Danilo Inchingolo Andrea Palermo Gianna Dipalma The Effects of Periodontal Treatment on Rheumatoid Arthritis and of Anti-Rheumatic Drugs on Periodontitis: A Systematic Review International Journal of Molecular Sciences cytokines disease-modifying anti-rheumatic drugs non-surgical periodontal treatment oral microbiota periodontitis rheumatoid arthritis |
| title | The Effects of Periodontal Treatment on Rheumatoid Arthritis and of Anti-Rheumatic Drugs on Periodontitis: A Systematic Review |
| title_full | The Effects of Periodontal Treatment on Rheumatoid Arthritis and of Anti-Rheumatic Drugs on Periodontitis: A Systematic Review |
| title_fullStr | The Effects of Periodontal Treatment on Rheumatoid Arthritis and of Anti-Rheumatic Drugs on Periodontitis: A Systematic Review |
| title_full_unstemmed | The Effects of Periodontal Treatment on Rheumatoid Arthritis and of Anti-Rheumatic Drugs on Periodontitis: A Systematic Review |
| title_short | The Effects of Periodontal Treatment on Rheumatoid Arthritis and of Anti-Rheumatic Drugs on Periodontitis: A Systematic Review |
| title_sort | effects of periodontal treatment on rheumatoid arthritis and of anti rheumatic drugs on periodontitis a systematic review |
| topic | cytokines disease-modifying anti-rheumatic drugs non-surgical periodontal treatment oral microbiota periodontitis rheumatoid arthritis |
| url | https://www.mdpi.com/1422-0067/24/24/17228 |
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