Systemic Treatment for Metastatic Biliary Tract Cancer: State of the Art and a Glimpse to the Future
Recent years have seen some breakthroughs in the therapeutic landscape of advanced biliary tract cancer (BTC). Firstly, a better understanding of the molecular background of BTC has led to important improvements in the management of these hepatobiliary malignancies, with the advent of targeted agent...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Current Oncology |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1718-7729/29/2/50 |
| _version_ | 1827655835705147392 |
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| author | Alessandro Rizzo Angela Dalia Ricci Antonio Cusmai Silvana Acquafredda Giuseppe De Palma Giovanni Brandi Gennaro Palmiotti |
| author_facet | Alessandro Rizzo Angela Dalia Ricci Antonio Cusmai Silvana Acquafredda Giuseppe De Palma Giovanni Brandi Gennaro Palmiotti |
| author_sort | Alessandro Rizzo |
| collection | DOAJ |
| description | Recent years have seen some breakthroughs in the therapeutic landscape of advanced biliary tract cancer (BTC). Firstly, a better understanding of the molecular background of BTC has led to important improvements in the management of these hepatobiliary malignancies, with the advent of targeted agents representing an unprecedented paradigm shift, as witnessed by the FDA approval of pemigatinib and infigratinib for FGFR2-rearranged and ivosidenib in IDH1-mutant cholangiocarcinoma. In addition, several novel treatments are under assessment, including immune checkpoint inhibitors and combination chemotherapies. In the current review, we provide an overview of systemic treatment for metastatic BTC, summarizing recent clinical data on chemotherapy as well as the main results of targeted therapies and immunotherapy. |
| first_indexed | 2024-03-09T22:14:10Z |
| format | Article |
| id | doaj.art-4a27d1ea4b4a4df0a1bf3d8ba5993a70 |
| institution | Directory Open Access Journal |
| issn | 1198-0052 1718-7729 |
| language | English |
| last_indexed | 2024-03-09T22:14:10Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj.art-4a27d1ea4b4a4df0a1bf3d8ba5993a702023-11-23T19:26:36ZengMDPI AGCurrent Oncology1198-00521718-77292022-01-0129255156410.3390/curroncol29020050Systemic Treatment for Metastatic Biliary Tract Cancer: State of the Art and a Glimpse to the FutureAlessandro Rizzo0Angela Dalia Ricci1Antonio Cusmai2Silvana Acquafredda3Giuseppe De Palma4Giovanni Brandi5Gennaro Palmiotti6Struttura Semplice Dipartimentale di Oncologia Medica per la Presa in Carico Globale del Paziente Oncologico “Don Tonino Bello”, I.R.C.C.S. Istituto Tumori “Giovanni Paolo II”, Viale Orazio Flacco 65, 70124 Bari, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi University Hospital, 40138 Bologna, ItalyStruttura Semplice Dipartimentale di Oncologia Medica per la Presa in Carico Globale del Paziente Oncologico “Don Tonino Bello”, I.R.C.C.S. Istituto Tumori “Giovanni Paolo II”, Viale Orazio Flacco 65, 70124 Bari, ItalyStruttura Semplice Dipartimentale di Oncologia Medica per la Presa in Carico Globale del Paziente Oncologico “Don Tonino Bello”, I.R.C.C.S. Istituto Tumori “Giovanni Paolo II”, Viale Orazio Flacco 65, 70124 Bari, ItalyInstitutional BioBank, Experimental Oncology and Biobank Management Unit, IRCCS Istituto Tumori “Giovanni Paolo II”, Viale Orazio Flacco 65, 70124 Bari, ItalyDepartment of Experimental, Diagnostic and Specialty Medicine, S. Orsola-Malpighi University Hospital, 40138 Bologna, ItalyStruttura Semplice Dipartimentale di Oncologia Medica per la Presa in Carico Globale del Paziente Oncologico “Don Tonino Bello”, I.R.C.C.S. Istituto Tumori “Giovanni Paolo II”, Viale Orazio Flacco 65, 70124 Bari, ItalyRecent years have seen some breakthroughs in the therapeutic landscape of advanced biliary tract cancer (BTC). Firstly, a better understanding of the molecular background of BTC has led to important improvements in the management of these hepatobiliary malignancies, with the advent of targeted agents representing an unprecedented paradigm shift, as witnessed by the FDA approval of pemigatinib and infigratinib for FGFR2-rearranged and ivosidenib in IDH1-mutant cholangiocarcinoma. In addition, several novel treatments are under assessment, including immune checkpoint inhibitors and combination chemotherapies. In the current review, we provide an overview of systemic treatment for metastatic BTC, summarizing recent clinical data on chemotherapy as well as the main results of targeted therapies and immunotherapy.https://www.mdpi.com/1718-7729/29/2/50biliary tract cancercholangiocarcinomachemotherapyFGFR2IDH1immunotherapy |
| spellingShingle | Alessandro Rizzo Angela Dalia Ricci Antonio Cusmai Silvana Acquafredda Giuseppe De Palma Giovanni Brandi Gennaro Palmiotti Systemic Treatment for Metastatic Biliary Tract Cancer: State of the Art and a Glimpse to the Future Current Oncology biliary tract cancer cholangiocarcinoma chemotherapy FGFR2 IDH1 immunotherapy |
| title | Systemic Treatment for Metastatic Biliary Tract Cancer: State of the Art and a Glimpse to the Future |
| title_full | Systemic Treatment for Metastatic Biliary Tract Cancer: State of the Art and a Glimpse to the Future |
| title_fullStr | Systemic Treatment for Metastatic Biliary Tract Cancer: State of the Art and a Glimpse to the Future |
| title_full_unstemmed | Systemic Treatment for Metastatic Biliary Tract Cancer: State of the Art and a Glimpse to the Future |
| title_short | Systemic Treatment for Metastatic Biliary Tract Cancer: State of the Art and a Glimpse to the Future |
| title_sort | systemic treatment for metastatic biliary tract cancer state of the art and a glimpse to the future |
| topic | biliary tract cancer cholangiocarcinoma chemotherapy FGFR2 IDH1 immunotherapy |
| url | https://www.mdpi.com/1718-7729/29/2/50 |
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