RNA interference is responsible for reduction of transgene expression after Sleeping Beauty transposase mediated somatic integration.

BACKGROUND: Integrating non-viral vectors based on transposable elements are widely used for genetically engineering mammalian cells in functional genomics and therapeutic gene transfer. For the Sleeping Beauty (SB) transposase system it was demonstrated that convergent transcription driven by the S...

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Bibliographic Details
Main Authors: Christina Rauschhuber, Anja Ehrhardt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3343047?pdf=render

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