Inert and seed-competent tau monomers suggest structural origins of aggregation
Tauopathies feature progressive accumulation of tau amyloids. Pathology may begin when these amplify from a protein template, or seed, whose structure is unknown. We have purified and characterized distinct forms of tau monomer—inert (Mi) and seed-competent (Ms). Recombinant Ms triggered intracellul...
Main Authors: | Hilda Mirbaha, Dailu Chen, Olga A Morazova, Kiersten M Ruff, Apurwa M Sharma, Xiaohua Liu, Mohammad Goodarzi, Rohit V Pappu, David W Colby, Hamid Mirzaei, Lukasz A Joachimiak, Marc I Diamond |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-07-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/36584 |
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