Alterations in Circulating Monocytes Predict COVID-19 Severity and Include Chromatin Modifications Still Detectable Six Months after Recovery
An early analysis of circulating monocytes may be critical for predicting COVID-19 course and its sequelae. In 131 untreated, acute COVID-19 patients at emergency room arrival, monocytes showed decreased surface molecule expression, including low HLA-DR, in association with an inflammatory cytokine...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/9/1253 |
| _version_ | 1797520108406439936 |
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| author | Alberto Utrero-Rico Cecilia González-Cuadrado Marta Chivite-Lacaba Oscar Cabrera-Marante Rocío Laguna-Goya Patricia Almendro-Vazquez Carmen Díaz-Pedroche María Ruiz-Ruigómez Antonio Lalueza María Dolores Folgueira Enrique Vázquez Ana Quintas Marcos J. Berges-Buxeda Moisés Martín-Rodriguez Ana Dopazo Antonio Serrano-Hernández José María Aguado Estela Paz-Artal |
| author_facet | Alberto Utrero-Rico Cecilia González-Cuadrado Marta Chivite-Lacaba Oscar Cabrera-Marante Rocío Laguna-Goya Patricia Almendro-Vazquez Carmen Díaz-Pedroche María Ruiz-Ruigómez Antonio Lalueza María Dolores Folgueira Enrique Vázquez Ana Quintas Marcos J. Berges-Buxeda Moisés Martín-Rodriguez Ana Dopazo Antonio Serrano-Hernández José María Aguado Estela Paz-Artal |
| author_sort | Alberto Utrero-Rico |
| collection | DOAJ |
| description | An early analysis of circulating monocytes may be critical for predicting COVID-19 course and its sequelae. In 131 untreated, acute COVID-19 patients at emergency room arrival, monocytes showed decreased surface molecule expression, including low HLA-DR, in association with an inflammatory cytokine status and limited anti-SARS-CoV-2-specific T cell response. Most of these alterations had normalized in post-COVID-19 patients 6 months after discharge. Acute COVID-19 monocytes transcriptome showed upregulation of anti-inflammatory tissue repair genes such as <i>BCL6</i>, <i>AREG</i> and <i>IL-10</i> and increased accessibility of chromatin. Some of these transcriptomic and epigenetic features still remained in post-COVID-19 monocytes. Importantly, a poorer expression of surface molecules and low <i>IRF1</i> gene transcription in circulating monocytes at admission defined a COVID-19 patient group with impaired SARS-CoV-2-specific T cell response and increased risk of requiring intensive care or dying. An early analysis of monocytes may be useful for COVID-19 patient stratification and for designing innate immunity-focused therapies. |
| first_indexed | 2024-03-10T07:52:10Z |
| format | Article |
| id | doaj.art-4a29462cbe8f4503bb6ef3f6b95b80a8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T07:52:10Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-4a29462cbe8f4503bb6ef3f6b95b80a82023-11-22T12:09:20ZengMDPI AGBiomedicines2227-90592021-09-0199125310.3390/biomedicines9091253Alterations in Circulating Monocytes Predict COVID-19 Severity and Include Chromatin Modifications Still Detectable Six Months after RecoveryAlberto Utrero-Rico0Cecilia González-Cuadrado1Marta Chivite-Lacaba2Oscar Cabrera-Marante3Rocío Laguna-Goya4Patricia Almendro-Vazquez5Carmen Díaz-Pedroche6María Ruiz-Ruigómez7Antonio Lalueza8María Dolores Folgueira9Enrique Vázquez10Ana Quintas11Marcos J. Berges-Buxeda12Moisés Martín-Rodriguez13Ana Dopazo14Antonio Serrano-Hernández15José María Aguado16Estela Paz-Artal17Instituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, SpainInstituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, SpainInstituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, SpainInstituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, SpainInstituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, SpainInstituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, SpainInstituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, SpainInstituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, SpainInstituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, SpainInstituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, SpainGenomics Unit, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, SpainGenomics Unit, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, SpainInstituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, SpainInstituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, SpainGenomics Unit, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, SpainInstituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, SpainInstituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, SpainInstituto de Investigación Sanitaria 12 de Octubre (imas12), 28041 Madrid, SpainAn early analysis of circulating monocytes may be critical for predicting COVID-19 course and its sequelae. In 131 untreated, acute COVID-19 patients at emergency room arrival, monocytes showed decreased surface molecule expression, including low HLA-DR, in association with an inflammatory cytokine status and limited anti-SARS-CoV-2-specific T cell response. Most of these alterations had normalized in post-COVID-19 patients 6 months after discharge. Acute COVID-19 monocytes transcriptome showed upregulation of anti-inflammatory tissue repair genes such as <i>BCL6</i>, <i>AREG</i> and <i>IL-10</i> and increased accessibility of chromatin. Some of these transcriptomic and epigenetic features still remained in post-COVID-19 monocytes. Importantly, a poorer expression of surface molecules and low <i>IRF1</i> gene transcription in circulating monocytes at admission defined a COVID-19 patient group with impaired SARS-CoV-2-specific T cell response and increased risk of requiring intensive care or dying. An early analysis of monocytes may be useful for COVID-19 patient stratification and for designing innate immunity-focused therapies.https://www.mdpi.com/2227-9059/9/9/1253circulating monocytesCOVID-19HLA-DRtranscriptomechromatin accessibility |
| spellingShingle | Alberto Utrero-Rico Cecilia González-Cuadrado Marta Chivite-Lacaba Oscar Cabrera-Marante Rocío Laguna-Goya Patricia Almendro-Vazquez Carmen Díaz-Pedroche María Ruiz-Ruigómez Antonio Lalueza María Dolores Folgueira Enrique Vázquez Ana Quintas Marcos J. Berges-Buxeda Moisés Martín-Rodriguez Ana Dopazo Antonio Serrano-Hernández José María Aguado Estela Paz-Artal Alterations in Circulating Monocytes Predict COVID-19 Severity and Include Chromatin Modifications Still Detectable Six Months after Recovery Biomedicines circulating monocytes COVID-19 HLA-DR transcriptome chromatin accessibility |
| title | Alterations in Circulating Monocytes Predict COVID-19 Severity and Include Chromatin Modifications Still Detectable Six Months after Recovery |
| title_full | Alterations in Circulating Monocytes Predict COVID-19 Severity and Include Chromatin Modifications Still Detectable Six Months after Recovery |
| title_fullStr | Alterations in Circulating Monocytes Predict COVID-19 Severity and Include Chromatin Modifications Still Detectable Six Months after Recovery |
| title_full_unstemmed | Alterations in Circulating Monocytes Predict COVID-19 Severity and Include Chromatin Modifications Still Detectable Six Months after Recovery |
| title_short | Alterations in Circulating Monocytes Predict COVID-19 Severity and Include Chromatin Modifications Still Detectable Six Months after Recovery |
| title_sort | alterations in circulating monocytes predict covid 19 severity and include chromatin modifications still detectable six months after recovery |
| topic | circulating monocytes COVID-19 HLA-DR transcriptome chromatin accessibility |
| url | https://www.mdpi.com/2227-9059/9/9/1253 |
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