Expression Pattern of Myelin-Related Apolipoprotein D in Human Multiple Sclerosis Lesions
Apolipoprotein D (Apo D) is a key molecule in the lipid transport during homeostasis and repair processes in normal and pathological conditions of the nervous system with a putative neuroprotective effect. In the last decades, huge experimental efforts have been made to know the exact mechanism of a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-08-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2018.00254/full |
| _version_ | 1818202590629855232 |
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| author | Ana Navarro Ana Navarro Ana Navarro Beatriz Rioseras Eva del Valle Eva del Valle Eva del Valle Eva Martínez-Pinilla Eva Martínez-Pinilla Eva Martínez-Pinilla Aurora Astudillo Aurora Astudillo Jorge Tolivia Jorge Tolivia Jorge Tolivia |
| author_facet | Ana Navarro Ana Navarro Ana Navarro Beatriz Rioseras Eva del Valle Eva del Valle Eva del Valle Eva Martínez-Pinilla Eva Martínez-Pinilla Eva Martínez-Pinilla Aurora Astudillo Aurora Astudillo Jorge Tolivia Jorge Tolivia Jorge Tolivia |
| author_sort | Ana Navarro |
| collection | DOAJ |
| description | Apolipoprotein D (Apo D) is a key molecule in the lipid transport during homeostasis and repair processes in normal and pathological conditions of the nervous system with a putative neuroprotective effect. In the last decades, huge experimental efforts have been made to know the exact mechanism of action of Apo D, even though, it remains an open question. In this regard, studies in mammals and flies have suggested that Apo D seems to act through a variety of cellular mechanisms related with its ability to selectively bind different lipid ligands. For instance, this apolipoprotein is required to myelin compaction, it participates in axon regeneration/remyelination, and it can control the magnitude and timing of the inflammatory response after injury, promoting myelin clearance, and regulating the number of immune cells recruited to the damaged area. These, among others, are some of the reasons to study Apo D in multiple sclerosis (MS) pathology, where it could be particularly important since the autoimmune reaction against oligodendrocytes (OLGs) and myelin is generally assumed as the most plausible cause of this pathology. The aim of this work was to investigate the Apo D expression pattern in MS lesions, including active and inactive demyelinating plaques, and also remyelinating ones. Human brain tissues with inflammatory demyelination consistent with MS were used to quantify Apo D immunosignal in different lesions. Our results show a clear decrease of Apo D expression in all sclerosis plaques, being lower in the inactive than in active areas but recovers in the remyelination ones. Apo D is mainly produced by the matured OLGs of white matter and is located in cell processes surrounding the myelin sheath. All these data seem to indicate an important role of Apo D in myelination/remyelination processes as a molecule with a neuroprotective potential, and may serve as a good starting point for its study in MS. |
| first_indexed | 2024-12-12T03:11:52Z |
| format | Article |
| id | doaj.art-4a29c5612afd401cb7806b85ce65bc9d |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-12T03:11:52Z |
| publishDate | 2018-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-4a29c5612afd401cb7806b85ce65bc9d2022-12-22T00:40:23ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652018-08-011010.3389/fnagi.2018.00254341774Expression Pattern of Myelin-Related Apolipoprotein D in Human Multiple Sclerosis LesionsAna Navarro0Ana Navarro1Ana Navarro2Beatriz Rioseras3Eva del Valle4Eva del Valle5Eva del Valle6Eva Martínez-Pinilla7Eva Martínez-Pinilla8Eva Martínez-Pinilla9Aurora Astudillo10Aurora Astudillo11Jorge Tolivia12Jorge Tolivia13Jorge Tolivia14Instituto de Neurociencias del Principado de Asturias (INEUROPA), Asturias, SpainInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Asturias, SpainDepartamento de Morfología y Biología Celular, Facultad de Biología y Medicina, Universidad de Oviedo, Oviedo, SpainDepartamento de Morfología y Biología Celular, Facultad de Biología y Medicina, Universidad de Oviedo, Oviedo, SpainInstituto de Neurociencias del Principado de Asturias (INEUROPA), Asturias, SpainInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Asturias, SpainDepartamento de Morfología y Biología Celular, Facultad de Biología y Medicina, Universidad de Oviedo, Oviedo, SpainInstituto de Neurociencias del Principado de Asturias (INEUROPA), Asturias, SpainInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Asturias, SpainDepartamento de Morfología y Biología Celular, Facultad de Biología y Medicina, Universidad de Oviedo, Oviedo, SpainInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Asturias, SpainServicio de Anatomía Patológica, Hospital Universitario Central de Asturias, Oviedo, SpainInstituto de Neurociencias del Principado de Asturias (INEUROPA), Asturias, SpainInstituto de Investigación Sanitaria del Principado de Asturias (ISPA), Asturias, SpainDepartamento de Morfología y Biología Celular, Facultad de Biología y Medicina, Universidad de Oviedo, Oviedo, SpainApolipoprotein D (Apo D) is a key molecule in the lipid transport during homeostasis and repair processes in normal and pathological conditions of the nervous system with a putative neuroprotective effect. In the last decades, huge experimental efforts have been made to know the exact mechanism of action of Apo D, even though, it remains an open question. In this regard, studies in mammals and flies have suggested that Apo D seems to act through a variety of cellular mechanisms related with its ability to selectively bind different lipid ligands. For instance, this apolipoprotein is required to myelin compaction, it participates in axon regeneration/remyelination, and it can control the magnitude and timing of the inflammatory response after injury, promoting myelin clearance, and regulating the number of immune cells recruited to the damaged area. These, among others, are some of the reasons to study Apo D in multiple sclerosis (MS) pathology, where it could be particularly important since the autoimmune reaction against oligodendrocytes (OLGs) and myelin is generally assumed as the most plausible cause of this pathology. The aim of this work was to investigate the Apo D expression pattern in MS lesions, including active and inactive demyelinating plaques, and also remyelinating ones. Human brain tissues with inflammatory demyelination consistent with MS were used to quantify Apo D immunosignal in different lesions. Our results show a clear decrease of Apo D expression in all sclerosis plaques, being lower in the inactive than in active areas but recovers in the remyelination ones. Apo D is mainly produced by the matured OLGs of white matter and is located in cell processes surrounding the myelin sheath. All these data seem to indicate an important role of Apo D in myelination/remyelination processes as a molecule with a neuroprotective potential, and may serve as a good starting point for its study in MS.https://www.frontiersin.org/article/10.3389/fnagi.2018.00254/fulldemyelinationremyelinationmyelinaxon lossoligodendrocytesneurodegenerative diseases |
| spellingShingle | Ana Navarro Ana Navarro Ana Navarro Beatriz Rioseras Eva del Valle Eva del Valle Eva del Valle Eva Martínez-Pinilla Eva Martínez-Pinilla Eva Martínez-Pinilla Aurora Astudillo Aurora Astudillo Jorge Tolivia Jorge Tolivia Jorge Tolivia Expression Pattern of Myelin-Related Apolipoprotein D in Human Multiple Sclerosis Lesions Frontiers in Aging Neuroscience demyelination remyelination myelin axon loss oligodendrocytes neurodegenerative diseases |
| title | Expression Pattern of Myelin-Related Apolipoprotein D in Human Multiple Sclerosis Lesions |
| title_full | Expression Pattern of Myelin-Related Apolipoprotein D in Human Multiple Sclerosis Lesions |
| title_fullStr | Expression Pattern of Myelin-Related Apolipoprotein D in Human Multiple Sclerosis Lesions |
| title_full_unstemmed | Expression Pattern of Myelin-Related Apolipoprotein D in Human Multiple Sclerosis Lesions |
| title_short | Expression Pattern of Myelin-Related Apolipoprotein D in Human Multiple Sclerosis Lesions |
| title_sort | expression pattern of myelin related apolipoprotein d in human multiple sclerosis lesions |
| topic | demyelination remyelination myelin axon loss oligodendrocytes neurodegenerative diseases |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2018.00254/full |
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