Hyperferritinemia, Low Circulating Iron and Elevated Hepcidin May Negatively Impact Outcome in COVID-19 Patients: A Pilot Study
Inflammation in COVID-19 produces intracellular iron overload with low circulating iron available for metabolic processes. The accumulated intracellular iron generates reactive species of oxygen and results in ferroptosis, a non-programmed cell death. Since no organ is spared, iron dysmetabolism inc...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/7/1364 |
| _version_ | 1797407694728986624 |
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| author | Robert Szabo Cristina Petrisor Constantin Bodolea Robert Simon Ioana Maries Sebastian Tranca Teodora Mocan |
| author_facet | Robert Szabo Cristina Petrisor Constantin Bodolea Robert Simon Ioana Maries Sebastian Tranca Teodora Mocan |
| author_sort | Robert Szabo |
| collection | DOAJ |
| description | Inflammation in COVID-19 produces intracellular iron overload with low circulating iron available for metabolic processes. The accumulated intracellular iron generates reactive species of oxygen and results in ferroptosis, a non-programmed cell death. Since no organ is spared, iron dysmetabolism increases the mortality and morbidity. Hepcidin and the mediator interleukin 6 are believed to play a role in the process. Our aim is to evaluate the predictive values of serologic iron and inflammatory parameters in COVID-19 critically ill patients. Hence, 24 patients were included. Hepcidin and interleukin 6, along with routine blood parameters, were determined and outcomes, such as death, multiple organ damage (MOD), anemia, and need for transfusions, were assessed. The results of this pilot study indicate that iron metabolism parameters individually, as well as models consisting of multiple laboratory and clinical variables, may predict the outcomes. Further larger studies are needed to validate the results of this pilot stud. However, this paper identifies a new direction for research. |
| first_indexed | 2024-03-09T03:46:19Z |
| format | Article |
| id | doaj.art-4a2ba8385682481ea12c1297cd174bdc |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T03:46:19Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-4a2ba8385682481ea12c1297cd174bdc2023-12-03T14:34:13ZengMDPI AGAntioxidants2076-39212022-07-01117136410.3390/antiox11071364Hyperferritinemia, Low Circulating Iron and Elevated Hepcidin May Negatively Impact Outcome in COVID-19 Patients: A Pilot StudyRobert Szabo0Cristina Petrisor1Constantin Bodolea2Robert Simon3Ioana Maries4Sebastian Tranca5Teodora Mocan6Physiology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaAnaesthesia II Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaAnaesthesia II Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaAnaesthesia II Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaAnaesthesia II Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaAnaesthesia II Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaPhysiology Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400000 Cluj-Napoca, RomaniaInflammation in COVID-19 produces intracellular iron overload with low circulating iron available for metabolic processes. The accumulated intracellular iron generates reactive species of oxygen and results in ferroptosis, a non-programmed cell death. Since no organ is spared, iron dysmetabolism increases the mortality and morbidity. Hepcidin and the mediator interleukin 6 are believed to play a role in the process. Our aim is to evaluate the predictive values of serologic iron and inflammatory parameters in COVID-19 critically ill patients. Hence, 24 patients were included. Hepcidin and interleukin 6, along with routine blood parameters, were determined and outcomes, such as death, multiple organ damage (MOD), anemia, and need for transfusions, were assessed. The results of this pilot study indicate that iron metabolism parameters individually, as well as models consisting of multiple laboratory and clinical variables, may predict the outcomes. Further larger studies are needed to validate the results of this pilot stud. However, this paper identifies a new direction for research.https://www.mdpi.com/2076-3921/11/7/1364COVID-19iron overloadinflammationhepcidininterleukin 6ferritin |
| spellingShingle | Robert Szabo Cristina Petrisor Constantin Bodolea Robert Simon Ioana Maries Sebastian Tranca Teodora Mocan Hyperferritinemia, Low Circulating Iron and Elevated Hepcidin May Negatively Impact Outcome in COVID-19 Patients: A Pilot Study Antioxidants COVID-19 iron overload inflammation hepcidin interleukin 6 ferritin |
| title | Hyperferritinemia, Low Circulating Iron and Elevated Hepcidin May Negatively Impact Outcome in COVID-19 Patients: A Pilot Study |
| title_full | Hyperferritinemia, Low Circulating Iron and Elevated Hepcidin May Negatively Impact Outcome in COVID-19 Patients: A Pilot Study |
| title_fullStr | Hyperferritinemia, Low Circulating Iron and Elevated Hepcidin May Negatively Impact Outcome in COVID-19 Patients: A Pilot Study |
| title_full_unstemmed | Hyperferritinemia, Low Circulating Iron and Elevated Hepcidin May Negatively Impact Outcome in COVID-19 Patients: A Pilot Study |
| title_short | Hyperferritinemia, Low Circulating Iron and Elevated Hepcidin May Negatively Impact Outcome in COVID-19 Patients: A Pilot Study |
| title_sort | hyperferritinemia low circulating iron and elevated hepcidin may negatively impact outcome in covid 19 patients a pilot study |
| topic | COVID-19 iron overload inflammation hepcidin interleukin 6 ferritin |
| url | https://www.mdpi.com/2076-3921/11/7/1364 |
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