Recombinant BCG: Innovations on an old vaccine. Scope of BCG strains and strategies to improve long lasting memory

Recombinant BCG: Innovations on an old vaccine. Scope of BCG strains and strategies to improve long lasting memory

BCG (Bacille Calmette-Guérin), an attenuated vaccine derived from Mycobacterium bovis, is the current vaccine of choice against tuberculosis (TB). Despite its protection against active TB in children, BCG has failed to protect adults against TB infection and active disease development, especially in...

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Bibliographic Details
Main Authors: Adeliane C da Costa, Sarah Veloso Nogueira, André eKipnis, Ana Paula eJunqueira-Kipnis
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Immunology
Subjects:
Memory, Long-Term
Tuberculosis
protection
strain differences
rBCG
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00152/full

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