Tanshinol alleviates ischemia-induced myocardial fibrosis via targeting ERK2 and disturbing the intermolecular autophosphorylation of ERK2Thr188

Tanshinol alleviates ischemia-induced myocardial fibrosis via targeting ERK2 and disturbing the intermolecular autophosphorylation of ERK2Thr188

Myocardial fibrosis is the fundamental remodeling process in myocardial ischemia (MI) and also the major contributor of heart failure and death. Tanshinol (Danshensu in Chinese, DSS), a major ingredient of salvia mitiorrhiza Bunge (Lamiaceae) root, exerted significant cardio protection effects. In t...

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Bibliographic Details
Main Authors: Wei Lei, Chun-yan Chen, Feng-jie Zhou, Yao-lei Ma, Yu-hong Li, Han Zhang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Tanshinol
Myocardial ischemia
Myocardial fibrosis
Intermolecular autophosphorylation
ERK2 Thr188
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223015275

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