Variation of glucose time in range in type 1 diabetes

Abstract Introduction The aim of the study was to assess the variation of glucose time in range (TIR) for persons with type 1 diabetes who perform intermittently scanned continuous glucose monitoring (isCGM). Methods Glucose data for 8 weeks were analysed for 166 persons. TIR was calculated over fou...

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Bibliographic Details
Main Authors: Klavs Würgler Hansen, Bo Martin Bibby
Format: Article
Language:English
Published: Wiley 2022-11-01
Series:Endocrinology, Diabetes & Metabolism
Subjects:
Online Access:https://doi.org/10.1002/edm2.379
Description
Summary:Abstract Introduction The aim of the study was to assess the variation of glucose time in range (TIR) for persons with type 1 diabetes who perform intermittently scanned continuous glucose monitoring (isCGM). Methods Glucose data for 8 weeks were analysed for 166 persons. TIR was calculated over four consecutive 2 weeks periods. Sixty‐one of the persons had two downloads with an interval of >3 months. Results A total of 140 individuals (84%) used multiple daily injection, and 26 (16%) used continuous insulin infusion. The within‐individual standard deviation (SD) for TIR was 6.3% corresponding to 95% limits of agreement for the difference between two TIR values of ±17.6%. Mean TIR calculated from the first and last 2 weeks was 52.2 ± 17.1% and 53.7 ± 16.4%, respectively (difference 1.5%, SD of the difference 10.4%, p = .07). For persons with two downloads separated by months, the SD of the difference in TIR was 12.6%. Conclusions The 95% limit of agreement for TIR is vast for persons using isCGM. It is difficult to draw firm conclusions regarding systematic differences when individual TIR from 2 weeks are compared. This may not be valid for users of insulin pumps with closed‐loop insulin delivery.
ISSN:2398-9238