Variation of glucose time in range in type 1 diabetes
Abstract Introduction The aim of the study was to assess the variation of glucose time in range (TIR) for persons with type 1 diabetes who perform intermittently scanned continuous glucose monitoring (isCGM). Methods Glucose data for 8 weeks were analysed for 166 persons. TIR was calculated over fou...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-11-01
|
| Series: | Endocrinology, Diabetes & Metabolism |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/edm2.379 |
| _version_ | 1811224920940609536 |
|---|---|
| author | Klavs Würgler Hansen Bo Martin Bibby |
| author_facet | Klavs Würgler Hansen Bo Martin Bibby |
| author_sort | Klavs Würgler Hansen |
| collection | DOAJ |
| description | Abstract Introduction The aim of the study was to assess the variation of glucose time in range (TIR) for persons with type 1 diabetes who perform intermittently scanned continuous glucose monitoring (isCGM). Methods Glucose data for 8 weeks were analysed for 166 persons. TIR was calculated over four consecutive 2 weeks periods. Sixty‐one of the persons had two downloads with an interval of >3 months. Results A total of 140 individuals (84%) used multiple daily injection, and 26 (16%) used continuous insulin infusion. The within‐individual standard deviation (SD) for TIR was 6.3% corresponding to 95% limits of agreement for the difference between two TIR values of ±17.6%. Mean TIR calculated from the first and last 2 weeks was 52.2 ± 17.1% and 53.7 ± 16.4%, respectively (difference 1.5%, SD of the difference 10.4%, p = .07). For persons with two downloads separated by months, the SD of the difference in TIR was 12.6%. Conclusions The 95% limit of agreement for TIR is vast for persons using isCGM. It is difficult to draw firm conclusions regarding systematic differences when individual TIR from 2 weeks are compared. This may not be valid for users of insulin pumps with closed‐loop insulin delivery. |
| first_indexed | 2024-04-12T08:58:13Z |
| format | Article |
| id | doaj.art-4a3057768daf4ca39cb10ba315f58de3 |
| institution | Directory Open Access Journal |
| issn | 2398-9238 |
| language | English |
| last_indexed | 2024-04-12T08:58:13Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj.art-4a3057768daf4ca39cb10ba315f58de32022-12-22T03:39:20ZengWileyEndocrinology, Diabetes & Metabolism2398-92382022-11-0156n/an/a10.1002/edm2.379Variation of glucose time in range in type 1 diabetesKlavs Würgler Hansen0Bo Martin Bibby1Diagnostic Centre Silkeborg Regional Hospital Silkeborg DenmarkSection for Biostatistics Department of Public Health, Aarhus University Aarhus DenmarkAbstract Introduction The aim of the study was to assess the variation of glucose time in range (TIR) for persons with type 1 diabetes who perform intermittently scanned continuous glucose monitoring (isCGM). Methods Glucose data for 8 weeks were analysed for 166 persons. TIR was calculated over four consecutive 2 weeks periods. Sixty‐one of the persons had two downloads with an interval of >3 months. Results A total of 140 individuals (84%) used multiple daily injection, and 26 (16%) used continuous insulin infusion. The within‐individual standard deviation (SD) for TIR was 6.3% corresponding to 95% limits of agreement for the difference between two TIR values of ±17.6%. Mean TIR calculated from the first and last 2 weeks was 52.2 ± 17.1% and 53.7 ± 16.4%, respectively (difference 1.5%, SD of the difference 10.4%, p = .07). For persons with two downloads separated by months, the SD of the difference in TIR was 12.6%. Conclusions The 95% limit of agreement for TIR is vast for persons using isCGM. It is difficult to draw firm conclusions regarding systematic differences when individual TIR from 2 weeks are compared. This may not be valid for users of insulin pumps with closed‐loop insulin delivery.https://doi.org/10.1002/edm2.379continuous glucose monitoringtime in rangetype 1 diabetes |
| spellingShingle | Klavs Würgler Hansen Bo Martin Bibby Variation of glucose time in range in type 1 diabetes Endocrinology, Diabetes & Metabolism continuous glucose monitoring time in range type 1 diabetes |
| title | Variation of glucose time in range in type 1 diabetes |
| title_full | Variation of glucose time in range in type 1 diabetes |
| title_fullStr | Variation of glucose time in range in type 1 diabetes |
| title_full_unstemmed | Variation of glucose time in range in type 1 diabetes |
| title_short | Variation of glucose time in range in type 1 diabetes |
| title_sort | variation of glucose time in range in type 1 diabetes |
| topic | continuous glucose monitoring time in range type 1 diabetes |
| url | https://doi.org/10.1002/edm2.379 |
| work_keys_str_mv | AT klavswurglerhansen variationofglucosetimeinrangeintype1diabetes AT bomartinbibby variationofglucosetimeinrangeintype1diabetes |