Effect of Teriparatide on Bone Mineral Density and Trabecular Bone Score in Type 2 Diabetic Patients with Osteoporosis: A Retrospective Cohort Study
The BMDs of the lumbar spine, whole femur, and femoral neck and TBS were measured. Change in BMD or TBS was defined as the BMD or TBS at follow-up, performed 1 year after baseline, minus baseline BMD or TBS. <i>Results:</i> This retrospective cohort study included 93 patients, of whom 52...
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MDPI AG
2022-03-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/58/4/481 |
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| author | Chihiro Munekawa Yoshitaka Hashimoto Noriyuki Kitagawa Takafumi Osaka Masahide Hamaguchi Michiaki Fukui |
| author_facet | Chihiro Munekawa Yoshitaka Hashimoto Noriyuki Kitagawa Takafumi Osaka Masahide Hamaguchi Michiaki Fukui |
| author_sort | Chihiro Munekawa |
| collection | DOAJ |
| description | The BMDs of the lumbar spine, whole femur, and femoral neck and TBS were measured. Change in BMD or TBS was defined as the BMD or TBS at follow-up, performed 1 year after baseline, minus baseline BMD or TBS. <i>Results:</i> This retrospective cohort study included 93 patients, of whom 52 received no medication, 26 received bisphosphonates, and 15 received weekly teriparatide. BMD of the lumbar spine increased in all three groups. There was no change in BMD of the whole femur and femoral neck in the no medication and bisphosphonates groups, whereas the BMD of the whole femur (from 0.73 (0.15) to 0.74 (0.15) g/cm<sup>2</sup>, <i>p</i> = 0.011) and femoral neck (from 0.59 (0.16) to 0.60 (0.16) g/cm<sup>2</sup>, <i>p</i> = 0.011) in the teriparatide group increased. The change in BMD of the femoral neck (no medication; −0.002 (0.034) g/cm<sup>2</sup>, bisphosphonates; −0.0001 (0.024) g/cm<sup>2</sup>, and teriparatide; 0.017 (0.022) g/cm<sup>2</sup>, <i>p</i> = 0.091) or TBS (no medication; −0.007 (0.051), bisphosphonates; −0.058 (0.258), and teriparatide; 0.021 (0.044), <i>p</i> = 0.191) in the teriparatide group tended to be higher than that in the other groups, although there was no statistically significant difference. <i>Conclusions:</i> Teriparatide increased the BMD of the femoral neck and TBS in osteoporosis patients with type 2 diabetes mellitus, compared to bisphosphonates and no medication. |
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| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T04:25:41Z |
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| spelling | doaj.art-4a3152922d684d0c9c80f722d1c259d62023-12-03T13:41:02ZengMDPI AGMedicina1010-660X1648-91442022-03-0158448110.3390/medicina58040481Effect of Teriparatide on Bone Mineral Density and Trabecular Bone Score in Type 2 Diabetic Patients with Osteoporosis: A Retrospective Cohort StudyChihiro Munekawa0Yoshitaka Hashimoto1Noriyuki Kitagawa2Takafumi Osaka3Masahide Hamaguchi4Michiaki Fukui5Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanThe BMDs of the lumbar spine, whole femur, and femoral neck and TBS were measured. Change in BMD or TBS was defined as the BMD or TBS at follow-up, performed 1 year after baseline, minus baseline BMD or TBS. <i>Results:</i> This retrospective cohort study included 93 patients, of whom 52 received no medication, 26 received bisphosphonates, and 15 received weekly teriparatide. BMD of the lumbar spine increased in all three groups. There was no change in BMD of the whole femur and femoral neck in the no medication and bisphosphonates groups, whereas the BMD of the whole femur (from 0.73 (0.15) to 0.74 (0.15) g/cm<sup>2</sup>, <i>p</i> = 0.011) and femoral neck (from 0.59 (0.16) to 0.60 (0.16) g/cm<sup>2</sup>, <i>p</i> = 0.011) in the teriparatide group increased. The change in BMD of the femoral neck (no medication; −0.002 (0.034) g/cm<sup>2</sup>, bisphosphonates; −0.0001 (0.024) g/cm<sup>2</sup>, and teriparatide; 0.017 (0.022) g/cm<sup>2</sup>, <i>p</i> = 0.091) or TBS (no medication; −0.007 (0.051), bisphosphonates; −0.058 (0.258), and teriparatide; 0.021 (0.044), <i>p</i> = 0.191) in the teriparatide group tended to be higher than that in the other groups, although there was no statistically significant difference. <i>Conclusions:</i> Teriparatide increased the BMD of the femoral neck and TBS in osteoporosis patients with type 2 diabetes mellitus, compared to bisphosphonates and no medication.https://www.mdpi.com/1648-9144/58/4/481teriparatidebone mineral densitytype 2 diabetes mellitusbone qualityfemoral neck |
| spellingShingle | Chihiro Munekawa Yoshitaka Hashimoto Noriyuki Kitagawa Takafumi Osaka Masahide Hamaguchi Michiaki Fukui Effect of Teriparatide on Bone Mineral Density and Trabecular Bone Score in Type 2 Diabetic Patients with Osteoporosis: A Retrospective Cohort Study Medicina teriparatide bone mineral density type 2 diabetes mellitus bone quality femoral neck |
| title | Effect of Teriparatide on Bone Mineral Density and Trabecular Bone Score in Type 2 Diabetic Patients with Osteoporosis: A Retrospective Cohort Study |
| title_full | Effect of Teriparatide on Bone Mineral Density and Trabecular Bone Score in Type 2 Diabetic Patients with Osteoporosis: A Retrospective Cohort Study |
| title_fullStr | Effect of Teriparatide on Bone Mineral Density and Trabecular Bone Score in Type 2 Diabetic Patients with Osteoporosis: A Retrospective Cohort Study |
| title_full_unstemmed | Effect of Teriparatide on Bone Mineral Density and Trabecular Bone Score in Type 2 Diabetic Patients with Osteoporosis: A Retrospective Cohort Study |
| title_short | Effect of Teriparatide on Bone Mineral Density and Trabecular Bone Score in Type 2 Diabetic Patients with Osteoporosis: A Retrospective Cohort Study |
| title_sort | effect of teriparatide on bone mineral density and trabecular bone score in type 2 diabetic patients with osteoporosis a retrospective cohort study |
| topic | teriparatide bone mineral density type 2 diabetes mellitus bone quality femoral neck |
| url | https://www.mdpi.com/1648-9144/58/4/481 |
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