Canine and human gastrointestinal stromal tumors display similar mutations in <it>c-KIT</it> exon 11

Canine and human gastrointestinal stromal tumors display similar mutations in <it>c-KIT</it> exon 11

<p>Abstract</p> <p>Background</p> <p>Gastrointestinal stromal tumors (GISTs) are common mesenchymal neoplasms in the gastrointestinal tract of humans and dogs. Little is known about the pathogenesis of these tumors. This study evaluated the role of <it>c-KIT </...

Full description

Bibliographic Details
Main Authors:	Hayes Schantel, Kiupel Matti, Bartlett Elizabeth, Gregory-Bryson Emmalena, Yuzbasiyan-Gurkan Vilma
Format:	Article
Language:	English
Published:	BMC 2010-10-01
Series:	BMC Cancer
Online Access:	http://www.biomedcentral.com/1471-2407/10/559

Similar Items

A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies
by: Marilia Takada, et al.
Published: (2018-03-01)

The Role of c-KIT in Tumorigenesis: Evaluation in Canine Cutaneous Mast Cell Tumors
by: Joshua D. Webster, et al.
Published: (2006-02-01)

Mutations in Exons 8 and 11 of <i>c-kit</i> Gene in Canine Subcutaneous Mast Cell Tumors and Their Association with Cell Proliferation
by: Polly Chen, et al.
Published: (2022-09-01)

Sorafenib and Doxorubicin Show Synergistic Effects in Human and Canine Osteosarcoma Cell Lines
by: Ya-Ting Yang, et al.
Published: (2022-08-01)

Computed tomography texture-based models for predicting KIT exon 11 mutation of gastrointestinal stromal tumors
by: Chuangen Guo, et al.
Published: (2023-10-01)

Establishment and Characterization of Cell Lines from Canine Metastatic Osteosarcoma
by: Ya-Ting Yang, et al.
Published: (2023-12-01)

SKP2 high expression, KIT exon 11 deletions, and gastrointestinal bleeding as predictors of poor prognosis in primary gastrointestinal stromal tumors.
by: Ang Lv, et al.
Published: (2013-01-01)

Exon 11 homozygous mutations and intron 10/exon 11 junction deletions in the KIT gene are associated with poor prognosis of patients with gastrointestinal stromal tumors
by: Yan‐Ying Shen, et al.
Published: (2020-09-01)

Talking KIT of the gastrointestinal stromal tumors
by: Kim Vaiphei
Published: (2016-01-01)

Preliminary Study of CT Radiomics Analysis on Differentiating Exon 9/11 Mutations of c-kit Gene in Gastrointestinal Stromal Tumors
by: Zilin HU, et al.
Published: (2022-02-01)

Mutational Analysis of <i>c-KIT</i> and <i>PDGFRA</i> in Canine Gastrointestinal Stromal Tumors (GISTs)
by: Maria Morini, et al.
Published: (2022-07-01)

Study of gastrointestinal stromal tumors with c-kit immunostaining
by: B Sigdel, et al.
Published: (2011-03-01)

A canine mastocytoma with oncogenic c-kit activation by intra-exonic alternative splicing
by: Mengrui Li, et al.
Published: (2024-06-01)

Clinical-radiomics-based treatment decision support for KIT Exon 11 deletion in gastrointestinal stromal tumors: a multi-institutional retrospective study
by: Yu Zhang, et al.
Published: (2023-08-01)

Molecular landscape and clinical significance of exon 11 mutations in KIT gene among patients with gastrointestinal stromal tumor: a retrospective exploratory study
by: Ruihua Zhao, et al.
Published: (2023-10-01)

Morphological Correlates of KIT and PDGFRA Genotypes in Gastrointestinal Stromal Tumour
by: Valli PRIYA, et al.
Published: (2020-05-01)

Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors
by: Tasker Andrew S, et al.
Published: (2010-07-01)

Predictive Value of a Radiomics Nomogram Model Based on Contrast-Enhanced Computed Tomography for KIT Exon 9 Gene Mutation in Gastrointestinal Stromal Tumors
by: Yuze Wei MS, et al.
Published: (2023-06-01)

Tumor-targeting Salmonella typhimurium A1-R suppressed an imatinib-resistant gastrointestinal stromal tumor with c-kit exon 11 and 17 mutations
by: Kentaro Miyake, et al.
Published: (2018-06-01)

Type and Gene Location of <i>KIT</i> Mutations Predict Progression-Free Survival to First-Line Imatinib in Gastrointestinal Stromal Tumors: A Look into the Exon
by: Lorena Incorvaia, et al.
Published: (2021-02-01)

Discovery of novel potential KIT inhibitors for the treatment of gastrointestinal stromal tumor
by: Jiang Lili, et al.
Published: (2021-04-01)

Diagnosis and Prognosis of Canine Melanocytic Neoplasms
by: Rebecca C. Smedley, et al.
Published: (2022-04-01)

Value of contrast-enhanced CT based radiomic machine learning algorithm in differentiating gastrointestinal stromal tumors with KIT exon 11 mutation: a two-center study
by: Bo Liu, et al.
Published: (2022-01-01)

Expression of Carboxypeptidase A3 and Tryptase as Markers for Lymph Node Metastasis of Canine Cutaneous Mast Cell Tumors
by: Tuddow Thaiwong, et al.
Published: (2022-02-01)

Imatinib as adjuvant treatment following resection of KIT-positive gastrointestinal stromal tumours
by: J Dretzke, et al.
Published: (2010-10-01)

Efficacy of SCF drug conjugate targeting c-KIT in gastrointestinal stromal tumor
by: Dengyang Zhang, et al.
Published: (2022-08-01)

Pitfalls in mutational testing and reporting of common <it>KIT </it>and <it>PDGFRA </it>mutations in gastrointestinal stromal tumors
by: Penzel Roland, et al.
Published: (2010-07-01)

The role of mutational analysis of KIT and PDGFRA in gastrointestinal stromal tumors in a clinical setting
by: Nannini Margherita, et al.
Published: (2011-05-01)

The progressive fragmentation of the KIT/PDGFRA wild-type (WT) gastrointestinal stromal tumors (GIST)
by: Margherita Nannini, et al.
Published: (2017-05-01)

Inhibition of KIT-glycosylation by 2-deoxyglucose abrogates KIT-signaling and combination with ABT-263 synergistically induces apoptosis in gastrointestinal stromal tumor.
by: Thomas Mühlenberg, et al.
Published: (2015-01-01)

Dysphagia, melanosis, gastrointestinal stromal tumors and a germinal mutation of the KIT gene in an Argentine family
by: Silvia Adela Ávila, et al.
Published: (2014-01-01)

The clinicopathologic observation, c-KIT gene mutation and clonal status of gastrointestinal stromal tumor in the sacrum
by: Gong Li, et al.
Published: (2009-06-01)

Unraveling the spectrum of KIT mutations in gastrointestinal stromal tumors: An Indian Tertiary Cancer Center Experience
by: Trupti Pai, et al.
Published: (2017-01-01)

Rare c-KIT c.1926delA and c.1936T>G Mutations in Exon 13 Define Imatinib Resistance in Gastrointestinal Stromal Tumors and Melanoma Patients: Case Reports and Cell Experiments
by: Chi Yan, et al.
Published: (2022-06-01)

Quantitative Expression of TYR, CD34, and CALD1 Discriminates Between Canine Oral Malignant Melanomas and Soft Tissue Sarcomas
by: Mayra F. Tsoi, et al.
Published: (2021-08-01)

Detection of c-kit gene mutations in Exon 11 of Leukemias
by: Syed Rizwan Hussain, et al.
Published: (2012-03-01)

Molecular Modeling Study of c-KIT/PDGFRα Dual Inhibitors for the Treatment of Gastrointestinal Stromal Tumors
by: Seketoulie Keretsu, et al.
Published: (2020-11-01)

Correlation of KIT and PDGFRA mutation status with clinicopathologic features in primary and recurrent or metastatic gastrointestinal stromal tumors
by: GU Yijin, LI Anqi, DONG Lei, XU Haimin, SHEN Xia, XIE Jialing, YUAN Fei, WANG Chaofu
Published: (2021-06-01)

THZ1 targeting CDK7 suppresses c-KIT transcriptional activity in gastrointestinal stromal tumours
by: Jianyi Sun, et al.
Published: (2022-09-01)

Early and Next-Generation KIT/PDGFRA Kinase Inhibitors and the Future of Treatment for Advanced Gastrointestinal Stromal Tumor
by: Sebastian Bauer, et al.
Published: (2021-07-01)