Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism
Introduction: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents. Methods: In total, 125 obese adolescents who entered th...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2017-04-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320317703451 |
| _version_ | 1797285391811739648 |
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| author | Sandro S Almeida Flavia C Corgosinho Carlos EN Amorim Marcos F Gregnani Raquel MS Campos Deborah CL Masquio Priscila L Sanches Aline P Ganen João B Pesquero Ana R Dâmaso Marco T Mello Sergio Tufik Ronaldo C Araújo |
| author_facet | Sandro S Almeida Flavia C Corgosinho Carlos EN Amorim Marcos F Gregnani Raquel MS Campos Deborah CL Masquio Priscila L Sanches Aline P Ganen João B Pesquero Ana R Dâmaso Marco T Mello Sergio Tufik Ronaldo C Araújo |
| author_sort | Sandro S Almeida |
| collection | DOAJ |
| description | Introduction: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents. Methods: In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year. Genomic DNA was extracted from circulating leukocytes. Results: Subjects with the II genotype in the non-metabolic syndrome group were only to increase their fat-free mass after therapy. Regarding lipid profile, subjects with ID and DD genotypes from both groups reduced their low-density lipoprotein cholesterol levels significantly. The metabolic parameters from the ID and DD genotypes of the non-metabolic syndrome group showed a significantly improved insulin response. Conclusion: In the present study, we showed that the ACE polymorphism was able to influence the fat-free mass in the I-carry allele in the non-metabolic syndrome group positively. In addition, the I-carry allele was able to improve the insulin resistance of the metabolic syndrome group significantly. These results suggest that the ACE I/D genotypes can influence, in different ways, the specific parameters of metabolism among obese adolescents submitted for long-term interdisciplinary therapy. |
| first_indexed | 2024-03-07T18:02:31Z |
| format | Article |
| id | doaj.art-4a3d972d004e42dba96521cf23f15a27 |
| institution | Directory Open Access Journal |
| issn | 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T18:02:31Z |
| publishDate | 2017-04-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-4a3d972d004e42dba96521cf23f15a272024-03-02T10:24:31ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1752-89762017-04-011810.1177/147032031770345110.1177_1470320317703451Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphismSandro S Almeida0Flavia C Corgosinho1Carlos EN Amorim2Marcos F Gregnani3Raquel MS Campos4Deborah CL Masquio5Priscila L Sanches6Aline P Ganen7João B Pesquero8Ana R Dâmaso9Marco T Mello10Sergio Tufik11Ronaldo C Araújo12Department of Biophysics, Federal University of São Paulo, BrazilPost-Graduate Program of Nutrition, Federal University of São Paulo, BrazilDepartment of Biophysics, Federal University of São Paulo, BrazilDepartment of Biophysics, Federal University of São Paulo, BrazilPost-Graduate Program of Nutrition, Federal University of São Paulo, BrazilPost-Graduate Program of Nutrition, Federal University of São Paulo, BrazilPost-Graduate Program of Nutrition, Federal University of São Paulo, BrazilPost-Graduate Program of Nutrition, Federal University of São Paulo, BrazilDepartment of Biophysics, Federal University of São Paulo, BrazilPost-Graduate Program of Nutrition, Federal University of São Paulo, BrazilPost-Graduate Program of Nutrition, Federal University of São Paulo, BrazilDepartment of Psychobiology, Federal University of São Paulo, BrazilDepartment of Biophysics, Federal University of São Paulo, BrazilIntroduction: The main purpose of the present study was to investigate whether I/D polymorphism of the ACE gene might affect metabolic changes related to the metabolic syndrome through a long-term interdisciplinary therapy in obese adolescents. Methods: In total, 125 obese adolescents who entered the interdisciplinary obesity programme were assigned to the following two subgroups: metabolic syndrome or non-metabolic syndrome. They were evaluated at baseline and after 1 year. Genomic DNA was extracted from circulating leukocytes. Results: Subjects with the II genotype in the non-metabolic syndrome group were only to increase their fat-free mass after therapy. Regarding lipid profile, subjects with ID and DD genotypes from both groups reduced their low-density lipoprotein cholesterol levels significantly. The metabolic parameters from the ID and DD genotypes of the non-metabolic syndrome group showed a significantly improved insulin response. Conclusion: In the present study, we showed that the ACE polymorphism was able to influence the fat-free mass in the I-carry allele in the non-metabolic syndrome group positively. In addition, the I-carry allele was able to improve the insulin resistance of the metabolic syndrome group significantly. These results suggest that the ACE I/D genotypes can influence, in different ways, the specific parameters of metabolism among obese adolescents submitted for long-term interdisciplinary therapy.https://doi.org/10.1177/1470320317703451 |
| spellingShingle | Sandro S Almeida Flavia C Corgosinho Carlos EN Amorim Marcos F Gregnani Raquel MS Campos Deborah CL Masquio Priscila L Sanches Aline P Ganen João B Pesquero Ana R Dâmaso Marco T Mello Sergio Tufik Ronaldo C Araújo Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism Journal of the Renin-Angiotensin-Aldosterone System |
| title | Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism |
| title_full | Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism |
| title_fullStr | Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism |
| title_full_unstemmed | Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism |
| title_short | Different metabolic responses induced by long-term interdisciplinary therapy in obese adolescents related to ACE I/D polymorphism |
| title_sort | different metabolic responses induced by long term interdisciplinary therapy in obese adolescents related to ace i d polymorphism |
| url | https://doi.org/10.1177/1470320317703451 |
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