Trajectory Shifts in Interdisciplinary Research of the Aryl Hydrocarbon Receptor—A Personal Perspective on Thymus and Skin
Identifying historical trajectories is a useful exercise in research, as it helps clarify important, perhaps even “paradigmatic”, shifts in thinking and moving forward in science. In this review, the development of research regarding the role of the transcription factor “aryl hydrocarbon receptor” (...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/22/4/1844 |
| _version_ | 1797396753928945664 |
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| author | Charlotte Esser |
| author_facet | Charlotte Esser |
| author_sort | Charlotte Esser |
| collection | DOAJ |
| description | Identifying historical trajectories is a useful exercise in research, as it helps clarify important, perhaps even “paradigmatic”, shifts in thinking and moving forward in science. In this review, the development of research regarding the role of the transcription factor “aryl hydrocarbon receptor” (AHR) as a mediator of the toxicity of environmental pollution towards a link between the environment and a healthy adaptive response of the immune system and the skin is discussed. From this fascinating development, the opportunities for targeting the AHR in the therapy of many diseases become clear. |
| first_indexed | 2024-03-09T00:55:27Z |
| format | Article |
| id | doaj.art-4a3ec7a18e394f4d9e4e25ea206ee9be |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T00:55:27Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-4a3ec7a18e394f4d9e4e25ea206ee9be2023-12-11T16:54:07ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01224184410.3390/ijms22041844Trajectory Shifts in Interdisciplinary Research of the Aryl Hydrocarbon Receptor—A Personal Perspective on Thymus and SkinCharlotte Esser0IUF-Leibniz Research Institute for Environmental Medicine, Auf’m Hennekamp 50, 40225 Düsseldorf, GermanyIdentifying historical trajectories is a useful exercise in research, as it helps clarify important, perhaps even “paradigmatic”, shifts in thinking and moving forward in science. In this review, the development of research regarding the role of the transcription factor “aryl hydrocarbon receptor” (AHR) as a mediator of the toxicity of environmental pollution towards a link between the environment and a healthy adaptive response of the immune system and the skin is discussed. From this fascinating development, the opportunities for targeting the AHR in the therapy of many diseases become clear.https://www.mdpi.com/1422-0067/22/4/1844thymusimmune systemskin2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin (TCDD)aryl hydrocarbon receptor (AHR)therapeutic target |
| spellingShingle | Charlotte Esser Trajectory Shifts in Interdisciplinary Research of the Aryl Hydrocarbon Receptor—A Personal Perspective on Thymus and Skin International Journal of Molecular Sciences thymus immune system skin 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin (TCDD) aryl hydrocarbon receptor (AHR) therapeutic target |
| title | Trajectory Shifts in Interdisciplinary Research of the Aryl Hydrocarbon Receptor—A Personal Perspective on Thymus and Skin |
| title_full | Trajectory Shifts in Interdisciplinary Research of the Aryl Hydrocarbon Receptor—A Personal Perspective on Thymus and Skin |
| title_fullStr | Trajectory Shifts in Interdisciplinary Research of the Aryl Hydrocarbon Receptor—A Personal Perspective on Thymus and Skin |
| title_full_unstemmed | Trajectory Shifts in Interdisciplinary Research of the Aryl Hydrocarbon Receptor—A Personal Perspective on Thymus and Skin |
| title_short | Trajectory Shifts in Interdisciplinary Research of the Aryl Hydrocarbon Receptor—A Personal Perspective on Thymus and Skin |
| title_sort | trajectory shifts in interdisciplinary research of the aryl hydrocarbon receptor a personal perspective on thymus and skin |
| topic | thymus immune system skin 2,3,7,8-tetrachlorodibenzo-<i>p</i>-dioxin (TCDD) aryl hydrocarbon receptor (AHR) therapeutic target |
| url | https://www.mdpi.com/1422-0067/22/4/1844 |
| work_keys_str_mv | AT charlotteesser trajectoryshiftsininterdisciplinaryresearchofthearylhydrocarbonreceptorapersonalperspectiveonthymusandskin |